Browsing by Author "Gupta, B"
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Item Abnormalities of haemostasis associated with congenital heart disease.(1977-01-01) Gupta, B; Jindal, S K; Mohanty, D; Das, K C; Bidwai, P S; Wahi, P LItem Absence of hyperlipidaemia in patients of chronic renal failure in Chandigarh.(1980-09-01) Sharma, B K; Jindal, S K; Rana, D S; Gupta, B; Kumar, MItem Adverse effects of hormone replacement therapy.(2001-12-09) Tripathi, B K; Gupta, B; Agarwal, A KItem Antenatal depression and its correlates - a cross-sectional study in an urban resettlement colony of Delhi(MRI Publication Pvt. Ltd., 2022-12) Gupta, B; Mangal, A; Thakur, A; Vaghela, JF; Sharma, A.Background- Antenatal depression is affecting 10% pregnant women worldwide with higher prevalence in developing countries. This causes poor maternal and foetal outcome and also affects cognitive development of the child. Aim and objective: To estimate magnitude of antenatal depression and its risk factors. Methodology- A cross-sectional survey was done at the antenatal clinic of community health department catering to an urban resettlement colony, East Delhi. Estimated sample size was 216 (including 10% non-response rate). Pregnant women attending the ANC clinic from October 2019 to February 2020 were enrolled. EPDS questionnaire was used to assess depression during pregnancy. Results-The antenatal depression was found in 11.8% subjects as per EPDS score. Working female and belonging to Muslim religion, past history of abortion, complications in previous pregnancy, financial debt, physical violence and substance use in family showed significant association with antenatal depression. Conclusion –Depression was prevalent among antenatal women and was found to be associated with various risk factors.Item Appendicular dyspepsia due to stones (foreign body).(1974-03-01) Gupta, B; Sircar, MItem Artemisinin derivatives for falciparum malaria.(1999-02-22) Tripathi, B K; Agarwal, A K; Gupta, BItem Blood culture gram stain, acridine orange stain and direct sensitivity-based antimicrobial therapy of bloodstream infection in patients with trauma.(2010-04) Behera, B; Mathur, P; Gupta, BPurpose: The purpose of this study was to ascertain if the simple practice of Gram stain, acridine orange stain and direct sensitivity determination of positive blood culture bottles could be used to guide early and appropriate treatment in trauma patients with clinical suspicion of sepsis. The study also aimed to evaluate the error in interpreting antimicrobial sensitivity by direct method when compared to standard method and find out if specific antibiotic-organism combination had more discrepancies. Findings from consecutive episodes of blood stream infection at an Apex Trauma centre over a 12-month period are summarized. Materials and Methods: A total of 509 consecutive positive blood cultures were subjected to Gram staining. AO staining was done in BacT/ALERT-positive Gram-stain negative blood cultures. Direct sensitivity was performed from 369 blood culture broths, showing single type of growth in Gram and acridine orange staining. Results of direct sensitivity were compared to conventional sensitivity for errors. Results: No 'very major' discrepancy was found in this study. About 5.2 and 1.8% minor error rates were noted in gram-positive and gram-negative bacteria, respectively, while comparing the two methods. Most of the discrepancies in gram-negative bacteria were noted in β lactam - β lactamase inhibitor combinations. Direct sensitivity testing was not reliable for reporting of methicillin and vancomycin resistance in Staphylococci. Conclusions: Gram stain result together with direct sensitivity testing is required for optimizing initial antimicrobial therapy in trauma patients with clinical suspicion of sepsis. Gram staining and AO staining proved particularly helpful in the early detection of candidaemia.Item C reactive protein--marker for atherothrombotic events.(1999-06-22) Gogna, A; Sinha, R S; Gupta, BItem C-reactive protein--marker for atherothrombotic events.(1999-08-25) Gogna, A; Sinha, R S; Gupta, BItem Calcium channel blockers in acute inflammation.(1988-01-01) Srivastava, V K; Saxena, K K; Gupta, BItem Characterization and changing minimum inhibitory concentration (MIC) of Acinetobacter species from a tertiary care setup.(2005-06-06) Capoor, M R; Nair, D; Srivastava, L; Gupta, B; Aggarwal, P128 isolates of Acinetobacter species from admitted and outdoor patients were subjected to biotyping and resistotyping. Resistance phenotype analysis included nine antibiotics and two betalactam inhibitor combination drugs. In 100 strains of Acinetobacter spp. ciprofloxacin, amikacin, cefotaxime and cefepime minimum inhibitory concentration (MIC) was done by agar dilution using NCCLS 2002 criteria. In forty-nine isolates MIC level was determined by E-strip also. Extended spectrum beta lactamase (ESBL) production was detected by double disc synergy technique. Inducible beta lactamases (IBL's) were detected by disc approximation method. The relationship between biotypes and resistance phenotype was analyzed. Majority of isolates (93.75%) were from admitted patients. The biotyping revealed Acinetobacter calcoaceticus-Acinetobacter baumannii complex (87.2%) to be the predominant species and they were isolated from tracheal aspirates of patients with ventilator associated pneumonia. By Kirby Bauer disc diffusion antimicrobial sensitivity testing Acinetobacter spp. were most sensitive to the combination of drug cefoperazone-sulbactam (95.6%) followed by meropenem (94.6%), piperacillin-tazobactam (92.6%). On screening incidence of Imipenem Nonsensitive Acinetobacter spp. (INSA) was (5.4%). Acinetobacter spp. were typable by six resistance phenotypes and six biotypes. Most common (66.6%) resistant phenotype of A. calcoaceticus-A. baumannii complex was susceptible to cefoperazone-sulbactam and or meropenem and or piperacillin-tazobactam. ESBL production was seen in 6% and IBL (Inducible Beta Lactamase) production was seen in 7% of Acinetobacter spp. The MIC90 for ciprofloxacin was =256 microg/ml, cefotaxime 512 microg/ml, cefepime 512 microg/ml, and amikacin 32 microg/ml. Multidrug resistance was seen in more than 90% of A. calcoaceticus-A. baumannii complex and 20% of Acinetobacter lwoffii. Acinetobacter spp. has other emerging novel mechanism of resistance that requires continuous research. Simpler, reproducible and reliable methods of biotyping and their subsequent correlation with resistotyping are more cost effective than molecular methods, which are available only in reference laboratories.Item Chloramphenicol resistant enteric fever.(1993-01-01) Chakravorty, B; Jain, N; Gupta, B; Rajvanshi, P; Sen, M K; Krishna, AIn recent times there have been several reports of chloramphenicol resistant enteric fever necessitating the use of other antimicrobial agents. Clinical profile of 15 chloramphenicol resistant patients of enteric fever was studied. Three such patients (20%) responded to chloramphenicol despite in vitro resistance to the drug. Hence chloramphenicol still remains the drug of first choice in enteric fever as a majority (68.4%--26 out of 38) of our bacteriologically proven enteric fever patients were cured by the drug. The remaining 12 cases responded satisfactorily to ciprofloxacin (46.7%), gentamicin (20%), and ofloxacin (13.3%). There was an increased incidence of complications among the 15 drug resistant cases as compared to 23 cases of chloramphenicol sensitive enteric fever observed during the same period.Item CK and ASAT: comparative evaluation as prognostic indicator in acute myocardial infarction.(1985-07-01) Saxena, K K; Gupta, B; Gopal, R; Srivastava, S S; Prasad, D NItem Clinical & biochemical profile of trichinellosis outbreak in north India.(2014-09) Sharma, Rahul K; Raghavendra, N; Mohanty, Smita; Tripathi, Brijendra K; Gupta, B; Goel, AnkitaBackground & objectives: Trichinellosis is a parasitic infection caused by Trichinella nematodes, acquired from consumption of raw meat. However, data from Indian subcontinent are limited. The aim of this study was to investigate the clinical and biochemical profile of a suspected trichinellosis outbreak in a village in Tehri Garhwal district of Uttarakhand state in north India. Methods: Three index cases presenting as acute febrile myalgia syndrome with eosinophilia, after consumption of uncooked pork in a common feast, were confirmed as trichinellosis on muscle biopsy. A detailed epidemiological survey was carried out in the affected community and all the people who participated in the feast were investigated for clinical and biochemical profile. Results: A total of 54 patients were evaluated in the study. The type of pork consumed included uncooked in 24 per cent (n=13), open fire roasted in 39 per cent (n=21) and fried in 37 per cent (n=20). Clinical symptoms were found in those who consumed pork in uncooked or open fire roasted form (n=34). These included fever with chills and myalgia (100%), periorbital oedema (67%), dyspnoea (9%), and dysphagia (3%). Laboratory parameters studied in both symptomatic and asymptomatic patients showed eosinophilia in 90 per cent (n=41), raised ESR in 98 per cent (n=45), and an elevated creatinine phosphokinase (CPK) level in 85 per cent (n=39). All symptomatic patients were treated with a short course of oral steroids and albendazole therapy. Conclusions: Trichinella infection is not uncommon in India, and should be suspected in case of acute febrile myalgia especially in areas, where habits of consumption of raw meat is more prevalent.Item Clinical and mycological profile of cryptococcosis in a tertiary care hospital.(2007-10-19) Capoor, M R; Nair, D; Deb, M; Gupta, B; Aggarwal, PThis study examined the extent of cryptococcosis in clinically diagnosed cases of meningitis in HIV-1 seropositive and apparently immunocompetent patients. One hundred and forty-six samples, obtained from 126 chronic meningitis patients comprised of cerebrospinal fluid (CSF), blood, sputum and urine. The samples were processed by standard microbiological procedures. Cryptococcal isolates were identified by microscopy, cultural characteristics, melanin production on niger seed agar and hydrolysis of urea. The isolates were further speciated on cannavanine glycine bromothymol blue (CGB) media. Cryptococcal antigen detection of CSF samples was performed by latex agglutination test (LAT). Minimum inhibitory concentration (MIC) of amphotericin B for the isolates was also tested. Cryptococcosis was diagnosed in 13 patients (eight HIV-1 seropositive and five apparently immunocompetent). Cryptococcus neoformans var. neoformans was the predominant isolate. Cryptococcal antigen was detected in all, whereas microscopy could detect yeast cells in nine patients. The isolates were sensitive to amphotericin B. CD4 cell counts ranged from 8 to 96/cu mm. The study concludes that all CSF samples with clinical diagnosis of subacute and chronic meningitis should be subjected to tests for detection of Cryptococcus in clinical laboratory irrespective of the immune status.Item Clofibrate, fibrinolysis and experimental myocardial damage.(1981-01-01) Saxena, K K; Gupta, B; Srivastava, R K; Singh, R C; Prasad, D NItem A comparative study of cimetidine, ranitidine & combination of ranitidine with oxyphenonium bromide in inhibition of nocturnal gastric secretion.(1987-11-01) Gupta, B; Singh, A K; Crowell, S BItem Comparison of medical treatment, coronary angioplasty and coronary artery bypass surgery in patients with chronic stable angina.(1995-08-01) Gogna, A; Gupta, B; Sinha, R SItem Comparison of two prognostic indices in acute myocardial infarction.(1985-10-01) Saxena, K K; Gupta, B; Gopal, R; Srivastava, S S; Kulshrestha, V K; Prasad, D NItem Coronary anatomy, left ventricular function and electrocardiographic stress testing three to four weeks after first myocardial infarction.(1988-01-01) Sethi, K K; Tyagi, S; Gupta, B; Gambhir, D S; Arora, R; Mansharamani, G G; Khalilullah, M