Browsing by Author "Gupta, R M"
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Item Alfa-feto protein in liver disorders in Indians.(1977-07-01) Gupta, R M; Bajpai, H S; Gupta, I M; Rao, C VItem Antilymphocytic serum. (A brief review of current concepts).(1979-12-01) Gupta, R M; Gupta, I MItem Appraisal of maternal and neonatal cord serum immunoglobulins in Indians.(1978-07-01) Gupta, R M; Sharma, D; Misra, GItem Cell mediated immune status in brain tumour patients.(1984-05-01) Sharma, R; Mohanty, S; Tandon, S C; Tiwari, V D; Gupta, R MItem Cellular and humoral immunity in iron deficiency and aplastic anaemias.(1987-08-01) Singh, S K; Singh, N K; Singh, V P; Gupta, R M; Srivastava, P KItem Clinical and immunologic study of patients of cancer cervix.(1979-11-01) Sharma, D; Gupta, R M; Kadian, VItem Clinical and morphological spectrum of glomerulonephritis (a hospital based study).(1987-06-01) Usha,; Singh, R G; Gupta, I M; Gupta, R MItem Divergent strains of human immunodeficiency virus type 1 circulating in India, subtyped by heteroduplex mobility assay.(2008-07-30) Sahni, A K; Kapila, K; Gupta, R MGenomic variations in HIV-1 represent a major problem in understanding disease progression, studying drug resistance and developing effective vaccines. Heteroduplex Mobility Assay (HMA) was used for analyzing HIV-1 subtypes resulting from genetic similarity or divergence of C2 -V3 -V5 region of envelope gene between HIV-1 strains obtained from clinical samples in a tertiary care center at Pune. DNA from the PBMCs of infected individuals was amplified by nested PCR. Heteroduplexes were then formed by denaturing DNA from the unknowns with DNA from the reference strains. The results were analyzed by polyacrylamide gel electrophoresis. Out of 177 samples analyzed, 170 were of subtype C (96%). Four samples were found to be of subtype B (2.2%); in three samples, no definitive assignment of subtype was possible by HMA and these perhaps could be circulating recombinant forms (CRFs) of HIV-1. These findings may have significant implications toward development of a candidate vaccine for India.Item Early detection of HIV-1 in infants by PCR.(2005-01-09) Sahni, A K; Gupta, R M; Jena, J; Nair, M N GInfants of HIV-infected mothers are at great risk of becoming infected with HIV during childbirth. Many infants acquire HIV during labor and delivery. Others can acquire HIV through the mixing of fetal and maternal blood as the placenta separates. The duration of membrane rupture, acute chorioamnionitis and invasive delivery techniques that increase the baby's contact with the mother's blood have been associated with higher risks of MTCT during labor and delivery. HIV is present in breast milk and risk of its transmission during breastfeeding depends on several factors, including: infant age, pattern of breastfeeding, breastfeeding duration, breast health, maternal viral load and maternal immune status. Infants born to HIV infected mothers carry their mother's antibodies in their blood into the second year of life, even if the infants themselves are not infected. For this reason, standard HIV antibody tests cannot reliably confirm HIV infection in infants until after the maternal antibodies have disappeared. Tests that can diagnose pediatric HIV infection accurately during the first year of life include HIV-PCR, CD4/CD8 counts, P24 antigen tests, and viral cultures. PCR offers an effective tool to reliably diagnose HIV in a pediatric age group. Nineteen infants born by normal delivery to HIV-1 seropositive mothers were studied by PCR for the HIV1 env gene. Thirteen babies (68.5%) were negative whereas 6 babies were found to be positive (31.5%). Although PCR is one of the most useful tests for this clinical situation, it is not definitive. Therefore, PCR should be interpreted with caution and repeated at regular defined intervals, preferably lasting until the HIV antibody status of the infant is resolved.Item Effect of levamisole as an immunomodulating agent in trophoblastic lesions.(1993-01-01) Khanna, A; Ojha, K N; Gupta, R MBoth cell mediated immunity and humoral immunity was assessed in 16 patients of hydatidiform mole and 6 patients of choriocarcinoma. Fifty percent patients of choriocarcinoma and 11 patients of vesicular mole were given levamisole (LVM) trial and were followed for 2 months. Absolute lymphocyte count (ALC) was significantly increased in vesicular mole after levamisole treatment but in choriocarcinoma no effect was obtained. Marked improvement of T cell rosette count was also seen in LVM treated patient of both vesicular mole (p < 0.001) and choriocarcinoma. Cutaneous DTH response to 2:4 DNCB in vesicular mole was also increased after LVM. Before treatment only 31.25% patients had strong cutaneous response but after treatment 53.35% patients had strong response, while cases of choriocarcinoma were unaffected. LVM also raised all the serum immunoglobulins (IgG, IgM, IgA) in both vesicular mole and choriocarcinoma. Hence, levamisole therapy was found to have a beneficial effect on both cellular and humoral immunity in the lesions of trophoblasts.Item Enteral hyperalimentation in malnourished surgical patients.(1984-09-01) Shukla, H S; Rao, R R; Banu, N; Gupta, R M; Yadav, R CItem Evaluation of cellular immunity in diabetic uraemics by cutaneous response to recall antigens and 2:4 dinitrochlorobenzene and T-cell rosette formation.(1993-04-01) Kuamr, S; Singh, R G; Gupta, R MTwenty diabetic uraemics and twenty two healthy matched controls comprised the material for this study. Cell mediated immunity was assessed by estimation of T-cell rosette percentage and cutaneous response to recall antigens--purified protein derivative, candida antigen and 2:4 dinitrochlorobenzene. Results analysis revealed depressed cell mediated immunity in diabetic uraemics in the form of impaired cutaneous response to recall antigens and reduction in T cell rosette percentage, in comparison to controls.Item Histological changes in kidney surrounding the renal cell carcinoma.(1987-10-01) Usha,; Singh, R G; Gupta, S N; Gupta, R M; Gupta, I M; Singh, P BItem HLA class-I and class-II antigen association in rheumatoid arthritis at Varanasi, India.(1996-01-01) Agrawal, V; Gupta, R M; Usha,; Sharma, S VClinical presentation of rheumatoid arthritis (RA) and its severity differs in different races. Genetic factors play a significant role in its predeliction. The present study was undertaken to find out association of HLA class I and class II antigens with rheumatoid arthritis prevalent in Asian Indians residing at Varanasi. Ninety rheumatoid arthritis patients strictly fulfilling American Rheumatism Association criteria were screened for prevalent HLA class I and class II antigen by Terasaki Microlympho-cytotoxicity test. Results were compared with 100 healthy controls and 35 Seronegative Spondyloarthritides cases (SSA). Rheumatoid arthritis patients showed increased frequency of HLA-A2 and B40 antigens compared to healthy controls (p < .001). SSA patients showed significantly increased Phenotype frequency (PF) of HLA-B27 (p < .0001) and B40 (p < .001). Significant detection of HLA-A2 exclusively in RA patients suggests a more positive association of A2 in rheumatoid arthritis at Varanasi. HLA-B40 could not be attributed absolute significance of association with SSA or RA as it showed increased frequency in both diseases.Item Immunity in leukemias.(1984-06-01) Ranjan, R; Singh, V P; Singh, N K; Srivastava, P K; Gupta, R M; Gupta, Y NItem Immunological status in acute viral hepatitis and fulminant hepatic failure.(1984-08-01) Singh, N K; Goyal, A K; Srivastava, P K; Gupta, R M; Tripathi, K KItem Immunologically induced injury in guineapigs & rats using testis as the target organ.(1974-01-01) Gupta, A; Gupta, R M; Gupta, I M; Thapliyal, J PItem Immunosuppressive effect of antithymocytes serum (ATS) on experimental allergic orchitis (EAO) in guineapigs (Cavia porcellus).(1979-09-01) Gupta, A; Gupta, R MItem Immunosuppressive effects of Amura rohitaka & prednisolone on experimental allergic orchitis in guineapigs.(1978-07-01) Gupta, A; Gupta, R M; Gupta, I M; Udupa, K N; Singh, L MItem Immunosuppressive effects of Amura rohitaka & prednisolone on normal guineapig.(1977-02-01) Gupta, A; Gupta, R M; Gupta, I M; Udupa, K N; Singh, L M
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