Browsing by Author "Gupta, Naveen"
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Item Antibiotic susceptibility of bacterial isolates in gingivitis and periodontitis.(2003-04-07) Saini, S; Aparna,; Gupta, Naveen; Mahajan, Anisha; Saini, O PThe present study was conducted to isolate aerobic as well as anaerobic microbes from patients of gingivitis and adult periodontitis and to study the susceptibility patterns of these isolates to different antibiotics. In our study all the samples belonging to the control as well as the study groups yielded microbes. Aerobes and facultative anaerobes were isolated from 100 percent and 96 percent cases of normal gingiva and orodental infections respectively. Anaerobes were isolated from 80 percent of the normal gingival samples and 97 percent of the cases of orodental infections. Metronidazole was found to be the best for the anaerobes while the aerobes and facultative anaerobes showed good susceptibility to cefazolin and cefotaxime.Item Bacteriological study of paediatric and adult chronic suppurative otitis media.(2005-07-10) Saini, Santosh; Gupta, Naveen; Aparna,; Seema,; Sachdeva, O PChronic suppurative otitis media (CSOM) is one of the commonest illnesses in ENT practice which requires medical attention all the more in children of poor socio-economic status having in past inadequate treatment and negligent medical care. The present study was conducted to find out the various aerobic and anaerobic microorganisms associated with CSOM in paediatric and adult cases and their current antimicrobial susceptibility pattern as a guide to therapy. Samples were collected from 109 clinically diagnosed cases of CSOM and processed according to standard protocols. Out of 74 paediatric CSOM cases, 72 (97.2%) were bacterial culture positive while out of 35 adult CSOM cases, 28 (80%) were culture positive. Bilateral CSOM was slightly more common in adults (25%) than paediatric (21.4%) age group. Polymicrobial nature of CSOM was noted in both paediatric (70.8%) and adult (71.4%) cases while number of organisms isolated per lesion was slightly higher in adults (2.5) as compared to paediatric (1.95) cases. In paediatric CSOM, Staphylococcus aureus was the commonest aerobic isolate while in adult CSOM, Pseudomonas aeruginosa was the commonest one. Among anaerobes Peptostreptococcus spp. was commonest in CSOM where as Prevotella melaninogenica in adult CSOM. Sensitivity of S. aureus to cefuroxime was 72.2% while that of gram negative bacilli was higher to cefotaxime (90 to 100%). Among anaerobes higher sensitivity was seen to metronidazole (98.6%), clindamycin (95.7%) and chloramphenicol (98.6%). In view of the polymicrobial etiology of CSOM, prompt appropriate antimicrobial therapy can effectively reverse the disease process thereby preventing longterm sequelae.Item Evaluation of germ tube test in various media.(2003-01-19) Arora, D R; Saini, S; Aparna,; Gupta, NaveenOne of the most valuable tests for the rapid presumptive identification of Candida albicans is germ tube production. Previously researchers have concluded superior results with serum in germ tube test. However, handling of pooled human serum has danger of acquisition of hepatitis and HIV infections. Therefore, in the present study we compared various media--pooled human serum, sterile horse serum, peptone water and tryptic soy broth. It was observed that human serum remains to be the best with 100% positivity for identification of C. albicans followed by horse serum (76.3%), peptone water (61.8%) and tryptic soy broth (61.8%).Item High level resistance in gram negative bacilli.(2004-10-22) Gupta, Naveen; Aparna,; Saini, Santosh; Arora, D RItem Moraxella catarrhalis as a respiratory pathogen.(2011-10) Gupta, Naveen; Arora, Shamma; Kundra, ShailjaBackground: Moraxella catarrhalis is gaining significance as a pathogen over few decades because of increased rate of isolation in respiratory specimens and due to emergence of multidrug resistant strains. Therefore, appropriate antimicrobial agents are required for eradication and prevention of spread of the organism. Material and Methods: -The study was conducted over 1-year period inpatients of lower respiratory tract infections (L.R.T.I.) in P.G.I.M.S. Rohtak (Haryana) . Assessment of clinical significance of M.catarrhalis was ascertained on the basis of preformed criteria. Results: A total of 63 clinically significant M. catarrhalis were isolated from a tertiary care hospital. The isolates showed maximum resistance to cotrimoxazole (82.5%), pencillin (77.7%), and ampicillin (71.4%) while susceptibility was maximum to cefotaxime (87.3%) followed by tetracycline (85.7%) ciprofloxacin (84.1%), erythromycin (80.9%) amikacin (79.3%), gentamycin (77.7%), and cefazolin (76.2%). Multidrug resistance to >3 antimicrobials was seen in 22 (34.9%) of cases. Conclusions: Predominant or pure growth of M.catarrhalis in throat swabs from cases of L.R.T.I. should be reported and treated by microbiologist and clinician respectively. Antibiotic therapy should be decided based on sensitivity report for rapid respose and recovery of patients.Item Pediatric Scrub Typhus in South Sikkim.(2012-04) Gupta, Naveen; Mittal, Veena; Gurung, B; Sherpa, UWe present five cases of paediatric Scrub typhus from Community Health Centre, Namchi, South Sikkim emphasize timely diagnosis of scrub typhus for appropriate management. Response to doxycycline was good, with fever subsiding within 48-72 hrs of starting the treatment. Four out of five cases completely recovered once appropriate medication was given.Item Resurgence of Vibrio cholerae O139 in Rohtak.(2005-02-10) Gupta, Naveen; Dewan, Shalini; Saini, SantoshItem Serological evidence of rickettsial infections in Delhi.(2012-04) Mittal, Veena; Gupta, Naveen; Bhattacharya, Dipesh; Kumar, Kaushal; Ichhpujani, R L; Singh, Sharda; Chhabra, Mala; Rana, U V SBackground & objectives: Rickettsial infections remain under-diagnosed due to lack of diagnostic facilities in developing world. Here we present our experience at National Centre for Disease Control, Delhi, about a serosurvey done in Delhi for rickettsial disease with easy to perform low cost, low expertise Weil Felix test. Methods: On the basis of cut-off titre obtained in healthy population, Weil Felix test results were interpreted along with clinical data. Entomological investigation was also carried out in select areas of Delhi. Rodents were trapped from houses and gardens and vector mites were collected. Results: When serum samples were collected during initial 5 yr period from patients with fever of unknown origin, seropositivity was 8.2 per cent whereas when rickettsial infection was kept as one of the differential diagnosis by clinicians seropositivity increased to 33.3 per cent. Rickettsial infections detected were scrub typhus (48.2%) followed by spotted fever group (27.5%) and typhus group (6.8%) during 2005-2009. In preliminary entomological survey vector mite Leptotombidium deliense was found on rodents. Interpretation & conclusions: Our findings showed that results of Weil Felix test should not be disregarded, rather clinically compatible cases should be treated to save lives.Item A Study of Hypertension and Obesity Among the Adult Population in a Rural Area Near NCT Delhi.(2013-08) Bhasin, Sanjiv K; Meena, Sonali; Mehta, Mukta; Sharma, Rahul; Gupta, NaveenBackground: The burden of non-communicable diseases (NCDs) in India is substantial and is estimated to increase, in rural areas too. Objectives: To study hypertension and obesity among the adult population in a rural area near Delhi. Materials/methods: A complete enumeration of the total population was done in Mandola village of Uttar Pradesh by conducting a house to house survey. After collecting information based data, the height, weight and blood pressure of all available family members were recorded as per standard procedures. Results: Data was collected from a total of 1124 persons. While there were 15.5% current smokers, 4.4% were consumers of alcohol. The prevalence of current smoking was 35.4% among the males and 3.3% among the females. It was observed that 20.2% of the males and 27.2% females were obese. Among the females, obesity was more likely among the housewives (p<0.001) and those of older age (p<0.001). The proportion of hypertensives was 16.0% in males and 13.0% in females. Among the males, hypertension was more common among the smokers than non-smokers (18.5% vs. 14.5%) and among current alcohol users than non-users (22.4% vs. 15.1%). We found several subjects, of both genders, who had both hypertension as well as obesity. Conclusion: The present study has shown that the burden of NCDs such as hypertension and obesity is quite substantial in a rural population.