Browsing by Author "Guha, S"
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Item Carotid intima media thickness: an independent marker for assessment of macrovascular risk in diabetic patients.(2005-04-22) Basu, A K; Pal, S K; Guha, S; Banerjee, R; Chatterjee, N; Bag, A K; Adhikary, AIn view of the global epidemic of diabetes with India being the hottest reservoir of the disease, it was tried to identify carotid intima media thickness as a surrogate marker for atherosclerosis in diabetic subjects. The study becomes more relevant because diabetes is now considered a disease of the endothelium and a risk equivalent of coronary atherosclerosis (paradigm shift). The study incorporated 41 normotensive patients of diabetes and 31 age and sex matched controls. Plasma glucose and lipid profiles were assessed in all and the carotid intima media thickness was measured. Results were statistically analysed for significance and correlation coefficient between values of plasma glucose and carotid intima media thickness. Results clearly showed that carotid intima media thickness abnormality can pick up atherosclerosis even if the lipid parameters are nearly normal. So it crystallises from this small study that, as a non-invasive test carotid intima media thickness is a better and early predictor of atherosclerosis in diabetic subjects. It also revealed the linear relationship between both fasting and postprandial blood sugar with carotid intima media thickness.Item A case of double outlet left ventricle--a rare congenital heart disease.(1996-03-01) Guha, S; Mukhopadhyay, P; Pain, S; Hazra, B RItem Clinical, echocardiographic and haemodynamic profile of hypertrophic cardiomyopathy.(1988-03-01) Maity, A K; Chatterjee, S S; Ganguly, K; Chowdhry, S; Dutta, S; Guha, S; Das, M K; Banerjee, A; Kar, C CItem A comparative study of balloon mitral valvuloplasty and closed mitral commissurotomy in patients with rheumatic mitral stenosis.(1999-07-22) Guha, S; Chattopadhyay, A; Nasipuri, J N; Hazra, B R; Chakraborty, T KRheumatic mitral stenosis is frequently encountered in our country. It affects younger population and is a major cause of morbidity Mitral valvotomy is the definitive therapy for this disease and can be achieved by closed mitral commissurotomy (CMC), open mitral commissurotomy (OMC) or by percutaneous transluminal mitral valvuloplasty (PTMV). Compared to CMC, PTMV is less invasive but more expensive at this moment. With the reduction of cost, PTMV may become the procedure of choice for the treatment of rheumatic mitral stenosis in future.Item An echo-cardiographic (M-mode & 2D) analysis of thalassaemia major.(1990-01-01) Senior, R; Batabyal, S K; Dutta, R N; Guha, S; Dutta, S; Bhattacharji, T D; Kundu, S C; Maity, A K; Kar, C C25 cases of thalassaemia major were studied by 2D and M-mode echocardiography. A significantly increased (p less than 0.001) mean value (100.8 +/- 27.37 msec, range 80 to 140 msec) of A2-E (early relaxation period) interval on M-mode was observed in thalassemia in comparison to mean level (82.6 +/- 5.7, range 60 to 100 msec) of control population. No significant differences were noted in FS % (fractional shortening) and EF% (ejection fraction) when compared to corresponding normal values respectively. Mean serum iron concentration (142.2 +/- 29.1 micrograms/dl, range 102 to 192 micrograms/dl) was significantly higher in thalassaemia as compared to normal population (mean 106.3 +/- 11.4 micrograms/dl, range 75 to 120 micrograms/dl). There was also a direct correlation between serum iron concentration and A2-E interval. 11 patients (44%) showed abnormal A2-E interval but only 3 patients (12%) showed abnormal percentage of FS and EF. It is therefore concluded that A2-E interval will help to detect early left ventricular dysfunction much before overt and irreversible heart failure becomes manifest and which will also help to optimise transfusion and chelation therapy.Item Effect of chitosan on lipid levels when administered concurrently with atorvastatin--a placebo controlled study.(2005-08-21) Guha, S; Pal, S K; Chatterjee, N; Sarkar, G; Pal, S; Guha, Sharmila; Basu, A K; Banerjee, RIn a placebo controlled trialthe lipid lowering effects of chitosan, a unique dietary fibre, was assessed when given along with atorvastatin 10 mg in patients with chronic coronary heart disease. Altogether 100 patients were studied. They were randomly allocated in two groups of 50 patients each. Patients of group A received atorvastatin 10 mg before dinner plus 2 g/day chitosan in two divided doses. The groupB patients received atorvastatin 10 mg plus placebo. Patients were followed up for a period of 6 weeks. There was significant reduction in mean body weight in group A patients (3.14% versus 1,29% of body weight, p<0.05). There was also a significant rise in HDL cholesterol value (3.8% versus 1.07%, p=0.02) in group A patients. However, there was no significant reduction in the mean values of total cholesterol, LDL cholesterol and triglyceride in the two groups, although group A patients showed marginally lower values.Item Experience with balloon valvuloplasty in pulmonary stenosis.(1989-05-01) Chatterjee, S S; Das, M K; Dutta, S; Ghosh, S; Sengupta, A; Guha, S; Choudhury, D; Das Biswas, A; Mitra, D; Maity, A KFourteen patients of pure valvular pulmonary stenosis of moderate to severe degree underwent balloon valvuloplasty in the Department of Cardiology, SSKM Hospital, Calcutta. Haemodynamic study revealed that immediately after valvuloplasty, right ventricular pressure dropped down from 125 +/- 17.18 mmHg. to 56.67 +/- 8.72 mmHg. (mean +/- SD). Restudy was done in each case after 4 weeks, which showed that right ventricular systolic pressure had further dropped down to 46.71 +/- 5.06 mmHg. (Mean +/- SD). Patients were further followed up for 6 to 15 months (mean 10 months). During the follow-up period, all the patients remained asymptomatic. Drop of right ventricular systolic pressure was maintained except in one case in which the peak systolic pressure gradient across the pulmonary valve was raised to 61 mmHg. from 24 mmHg., the gradient achieved immediately after valvuloplasty.Item Facilitation and/or inhibition of growth of sarcoma-180 ascites tumour by BCG: effects of BCG on tumour cell membrane.(1980-02-01) Ray, P K; De, B K; Guha, S; Saha, S; Raychaudhuri, SItem Pacing system malfunction--management by multi programmable pacemakers.(1987-05-01) Maity, A K; Chatterjee, S S; Ganguly, K; Guha, S; Dutta, S; Kar, C CItem Predictive efficacy of Framingham's risk score in Indian scenario--a retrospective case-control study.(2004-10-13) Guha, S; Basu, A K; Pal, S K; Chatterjee, N; Guha, Sharmila; Deb, P KTo assess the predictive ability of Framingham's risk score in primary prevention in our population, 252 cases and 212 age and sex matched controls were taken up for study. Those patients, who were presenting for the first time with acute coronarysyndrome (ACS) and who did not have any prior manifestations of coronary artery disease (CAD) and whose medical records were available formed the patient group. Framingham's risk score was calculated and the corresponding 10 years risk was assessed in each of them. The patients and controls were divided into two groups--diabetic and non-diabetic. Depending on the 10 years risk, they were further grouped into high risk (10 years risk > 20%), moderately high risk (10 years risk 10 to 20%) and low risk (10 years risk less than 10%). Results were compared and statistically analysed. In the diabetic patients with ACS 14% would have qualified as high risk, 33% as moderately high risk and 53% as low risk whereas in diabetic patients without any manifestation of CAD the distribution was 4% in the high risk, 54% in the moderately high risk and 42% in the low risk. In the non-diabetic subjects, amongst the patients of ACS, 20% would have been in high risk, 39% in moderately high risk and 41% in the low risk. The corresponding figures in the non-diabetic control subjects were 10% in high risk, 22% in the moderately high risk and 68% in the low risk. In the non-diabetic subjects, the mean risk was significantly more in patients than in controls (14.15% versus 8.61%, p <0.01). However, in the diabetic patients there was no significant difference in the mean projected risk between patients with ACS and patients without any manifestation of CAD (11.37% versus 10.41%, p>0.05).Item Preliminary studies on excretory components of a virulent strain (F-2) of Pseudomonas solanacearum.(1989-12-01) Basu, S; Guha, S; Pal, J N; Samajpati, NThe excretory material (EM) was isolated from the culture medium of a virulent strain (F-2) of Pseudomonas solanacearum. Electrophoretic studies depicted the heterogeneous nature of EM and the presence of released lipopolysaccharide in it. Both the exopolysaccharide and the released LPS contained D-galactose as the major sugar constituent together with D-glucose, N-acetyl-D-galactosamine and N-acetyl-D-glucosamine. In addition, L-rhamnose was present as a constituent sugar of the released LPS.Item Prognostic significance of risk factors in acute myocardial infarction in young.(1989-09-01) Maity, A K; Das, M K; Chatterjee, S S; Dutta, S; Guha, SThe study included 45 consecutive patients in the age group of 27 to 39 years presenting with AMI diagnosed by typical history, ECG changes and enzyme response. Prognostic significance of various risk factors in AMI in young was evaluated. There were 41 M (91.1%) and 4 F (8.9%) with mean age of 34.6 years. ECG showed anterior myocardial infarction (MI) in 18 (40%), inferior MI in 15(33.3%), Subendocardial inf in 10(22.5%) and combined anterior and inferior MI in 2 (4.5%) cases. Various risk factors were: Smoking (60%), hyperlipidemia (44.4%), stress (40%), hypertension (28.9%), family history (28.9%), diabetes mellitus (15.7%) and obesity (8.8%). Attention was given on atherogenic index (AI) (22.2%). Coronary angiogram was done in 20, which revealed significant coronary arterial obstruction in 15 cases; 3-vessel disease (n = 7), 2 vessel disease (n = 4) and single vessel disease (n = 4). Both 3 VD and 2 VD were associated with high AI. Risk factors (RF) were grouped as RFGI when combination of 3 or more RF were present, and RFG II when 2 or less RF were present. RFGI and RFGII were present in 40% and 60% cases respectively. Prognostically, patients were divided in two groups of MI-fatal (6) and nonfatal (39), the latter were subdivided into complicated (14) and uncomplicated (25). It was observed that more fatal cases were found in RFGI, whereas nonfatal uncomplicated MI was more in RFG II (P less than .001).Item Risk factors and their implication on silent myocardial ischaemia.(1990-01-01) Maity, A K; Das, M K; Chatterjee, S S; Roy, A; Guha, S; Dutta, S; Sinha, D; Ghosh, S PSixty-five cases were evaluated for silent myocardial ischaemia (SMI) by computerised treadmill test (TMT) and ambulatory electrocardiographic monitoring (AEM). There were 59 males and 6 females. The cases were divided into GP-I-stable angina (35 cases) GP-II-stable angina after myocardial infarction (15 cases) and GP-III-asymptomatic (15 cases). Age in each group ranged from 36 years to 62 years (GP-I), 40 years to 68 years (GP-II) and 36 years to 48 years (GP-III). Conventional risk factors viz. hypertension, diabetes mellitus, hyperlipidemia, smoking and family history were assessed with a view to see their implication on SMI. 43 patients (62.2%) were found to have SMI including mixed episodes. Out of these 43, TMT was positive in 29 patients (67.4%), AEM was positive in 41 patients (95.3%) and both TMT and AEM were positive in 27 patients (62.7%). Correlative analysis between risk factors and SMI revealed that higher number of was associated with not only more positive TMT and AEM test along with increased episodes of SMI but also increased degree of ST-T depression. It was also found that AEM is more sensitive than TMT (80% Vs 48%) for diagnosing SMI (SED = 9.03%), though specificity of the tests is same (93.3%).Item Risk factors of myocardial infarction in Indian women.(1987-11-01) Chatterjee, S S; Banerjee, A; Dutta, S; Guha, S; Mazumder, B; Sanyal, R; Maity, A K; Kar, C CItem Serum lipoprotein ratios as markers of insulin resistance: A study among non-diabetic acute coronary syndrome patients with impaired fasting glucose.(2015-01) Ray, S; Talukdar, A; Sonthalia, N; Saha, M; Kundu, S; Khanra, D; Guha, S; Basu, A K; Mukherjee, A; Ray, D; Ganguly, SBackground & objectives: Recent data suggest that insulin resistance can predict cardiovascular disease independently of the other risk factors, such as hypertension, visceral obesity or dyslipidaemia. However, the majority of available methods to evaluate insulin resistance are complicated to operate, expensive, and time consuming. This study was undertaken to assess whether serum lipoprotein ratios could predict insulin resistance in non-diabetic acute coronary syndrome (ACS) patients. Methods: Ninety non-diabetic patients with impaired fasting glucose admitted with a diagnosis of ACS were included in the study. At the time of admission fasting glucose and insulin concentrations were measured. The homeostatic model assessment-insulin resistance (HOMA-IR) was used for insulin resistance. The fasting serum total cholesterol (TC), triglycerides (TG) and high density lipoprotein cholesterol (HDL-C) levels were checked, and then TC/HDL-C and TG/HDL-C ratios were calculated. The areas under the curves (AUC) of the receiver operating characteristic (ROC) curves were used to compare the power of these serum lipoprotein ratios as markers. Results: Lipoprotein ratios were significantly higher in patients with HOMA-IR index > 2.5 as compared to patients with index <2.5 (P < 0.05). Both TG/HDL-C and TC/HDL-C ratios were significantly correlated with HOMA-IR (P<0.05). The area under the ROC curve of the TG/HDL-C and TC/HDL-C ratio for predicting insulin resistance was 0.80 (95% CI, 0.67 to 0.93), 0.78 (95% CI, 0.65 to 0.91), respectively. Interpretation & conclusions: The findings of this study demonstrate that serum lipoprotein ratios can provide a simple means of identifying insulin resistance and can be used as markers of insulin resistance and cardiovascular diseases risk in adult non-diabetic patients.Item Sociodemographic profile and clinical outcome of mild–moderate COVID-19 patients admitted in a dedicated COVID hospital during first wave of pandemic(Mrs Dipika Charan of MedScience (India) Publications, 2022-04) Mondal, SS; Bhadra, A; Guha, S; Chakraborty, A.Background: COVID-19 pandemic quickly became significantly major cause of worldwide morbidity and mortality over the next years till date in an unforeseen manner. Aims and Objectives: Our study aims at unfolding the sociodemographic, epidemiological, and clinical characteristics of this disease, based on a metropolitan dedicated tertiary care hospital of India. Materials and Methods: Along with patient particulars, we recorded sociodemographic data, presenting symptoms, vital parameters, and blood parameters based on a pre-designed questionnaire, followed by complication analysis for 101 patients. Written consent was taken from each of the respondent before the interview and ethical approval was taken from Institution Ethics Committee (IEC) of Medical College and Hospital. [(Ref No. MC/KOL/IEC/Non-Spon/842/11/2020), Date- 5/11/2020]. Results: This study justified the trend of already available data such as median age of presentation (40–69 years), higher urban population (85.1%), higher rate of infection in health-care professionals (12.9%), and in patients with poor socioeconomic status. It revealed increased community transmission (74.3% with no definitive exposure), higher number of symptomatic cases admission (89.1%) with most common symptoms being fever (46%), shortness of breath (45%), sore throat (32%), and cough (26%). Hypertension (48%) and diabetes (34%) were major comorbidities in patients who were also proportionally more symptomatic and experienced more adverse effects compared to non-comorbid patients. A major chunk of the patients (46.53%) required some form of oxygen support for their treatment. Most common adverse effect was disseminated intravascular coagulation (23.76%) among which 67.74% had one or more comorbidities. We also reported slightly higher number of deaths (6.9%) compared to what other similar studies found. Conclusion: History of probable exposure was not a sole risk factor of acquiring infection, that is, community transmission was evident. Healthcare professionals were at high risk of getting infected, persons with comorbidity are at the highest risk of developing symptoms as well as complications.Item Study on early intervention with ACE inhibitor in myocardical infarction and short term outcome.(2001-09-23) Hazra, B R; Roy, B P; Guha, S; Rakshit, K; Ghosh, M BThe present study was carried out on 100 patients with acute myocardial infarction (AMI) being treated with angiotensin converting enzyme (ACE) inhibitor and another 80 patients with conventional treatment but without ACE inhibitor during the period from May 1, 1995 to August 7, 1996 in Medical College, Calcutta. Clinical and other laboratory investigations including echocardiographic parameters were noted and recorded meticulously within 24-48 hours after AMI and repeated at 4th week. The present study based on non-invasive methods other than haemodynamic methods has shown that the echocardiographic assessment of left ventricular functional parameters after 4 weeks of ACE inhibitor therapy (n = 100) were better in treated group in comparison to control group without ACE inhibitor (n = 80) and the difference was statistically significant at 99% level of confidence. Overall mortality was 4% in ACE inhibitor group and 8.75% in the control group. This short term study with early intervention with ACE inhibitor within 48 hours of AMI has shown statistically significant evidence of beneficial effect of ACE inhibitor in improving the ventricular functional parameters and also reducing short term mortality from cardiac cause within 4 weeks compared to the group not receiving ACE inhibitors.Item A study on gender preference among pregnant mothers attending antenatal clinic of a tertiary care hospital, Kolkata(Mrs Dipika Charan of MedScience (India) Publications, 2022-03) Mukherjee, R; Bhattacharya, P; Guha, S; Chakraborty, A.Background: A balanced sex ratio is needed to stabilize India, a patriarchal subcontinent. Aim and Objective: The study aims to find out whether there is any association between the socio-demographic characters and perceived gender preference among the study subjects. Materials and Methods: The study is an observational, descriptive study with cross-sectional study design. An exit interview of 80 pregnant mothers, both primi and multigravida, selected by systematic random sampling attending antenatal clinic of Medical College, Kolkata for 1st time was conducted for 1 month, using a pre-designed pre-tested semi-structured data collection form after ethics committee approval. Statistical analyses were done using Chi-square tests, at P ? 0.05 level of significance in Statistical Package for Social Sciences. Results: Mean age of study participants was 24.15 ± 4.38 years. The majority (77.5%) of them belonged to age group 20–29 years. 58.8% mothers were nulliparous, 53.8% from rural areas, 63.7% followed Islam, 52.5% from joint family, 31.3% belonged to middle class. 95% of the mothers had no history of abortion. Regarding education, the majority (32.5%) of the study participants were educated till secondary level. Among their husbands, 28.7% were educated till middle level. 40% study participants had no any gender preference, 40% had male preference and 20% had female preference. Main reason behind male preference was an earlier female child. Some preferred daughters due to their earlier male child. Nulliparous mothers had no gender preference while lesser-educated mothers had gender preference. Conclusion: The majority of the study participants had gender preference. Male preference was more than female preference.Item Tricuspid atresia with D-transposition and common atrium.(1992-10-01) De, S K; Guha, SItem An unusual case of cor-triatriatum with dilated cardiomyopathy.(1988-03-01) Senior, R; Guha, S; Dutta, S; Chatterjee, S S; Banerjee, A; Maity, A K; Kar, C C