Browsing by Author "Goyal, S."

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    Adverse drug reaction profile of anticancer agents in a tertiary care centre of rural Maharashtra: a cross-sectional study
    (Medip Academy, 2023-09) Agrawal, P.; Narwane, S.; Gulve, P.; Kolhe, P.; Singhal, S.; Goyal, S.; Shukla, A.
    Background: The present study was undertaken to analyse the clinical spectrum, pattern of ADR reported, most common suspected drugs, timing of reporting of suspected ADR, outcome, severity and causality assessment of adverse drug reactions among oncology patients reported at our ADR monitoring Centre. Methods: The descriptive cross-sectional study was carried out for two months in the oncology department of a tertiary care rural hospital. ADR reporting form Version 2.4 was used for recording information of all patients of any gender and age who were suspected cases of adverse drug reactions receiving chemotherapy. Results: Total 83 ADRs were reported within the duration of two months. The number of males and females were 21 and 62, respectively with mean age 56.9±11.6 years for males and 59.6±8.8 years for females. The age group most commonly reported with suspected ADR was 61-70 years (28.9%). Of the 83 ADR reported, the most common suspected drug was Paclitaxel (47, 56.6%). The most common indications for the use of these anticancer drugs was reported to be CA breast (43, 51.8%). Most of the ADRs (38, 45.8%) were reported immediately. On applying Naranjo’s Causality Assessment Scale, 61 and 22 ADRs fell in the category of Probable and Possible, respectively. Conclusions: The occurrence of ADR among patients on chemotherapy is high. The reported ADR were common and predictable. Hence diligent monitoring in ADR may help manage and prevent morbidity associated with anti-cancer drugs.
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    The effect of vitamin D on haemoglobin, patient assessed disease activity and endoscopic assessment in ulcerative colitis patients with anaemia
    (Medip Academy, 2023-08) Dalal, K.; Goyal, S.; Goyal, S.
    Background: Anemia has a dramatic impact on patient's quality of life, yet anemia in patients with UC is still underdiagnosed and undertreated. Hepcidin has been identified to be a central regulator of iron absorption from the intestines and of plasma iron levels. In this study we evaluated the effect of vitamin D supplementation on haemoglobin levels, patient assessed disease activity and endoscopic assessment in ulcerative colitis (UC). Methods: In this prospective, open-labeled, parallel-group, randomized, comparative clinical study, we assigned newly diagnosed cases of UC with haemoglobin levels between 8-11 gm/dL to receive either standard therapy for 12 weeks or to receive oral 4000IU vitamin D3 along with standard therapy for 12 weeks. Results: Data from 60 patients were analyzed after 12 weeks. Supplementation with vitamin D3 significantly raised haemoglobin level in treatment group from (9.09±0.20) (Mean ± SEM) at baseline to 9.62±0.22 (Mean ± SEM) at 12 weeks. On assessment of abdominal pain with NRS scale at the end of treatment at 12 weeks the reduction in NRS score was to 3.47±0.29 in group I and to 2.23±0.21 in group II (p=0.0012) which was highly significant. There was also a statistically significant reduction in the Likert scale at the end of 4, 8 and 12 weeks in both groups. At week 12, there was no statistical difference between the two groups in improving the endoscopy score. Conclusions: Daily high dose vitamin D supplementation is beneficial in ameliorating UC symptoms like abdominal pain and has a positive effect on haemoglobin levels.
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    The impact of herpes zoster infection awareness program on myths, knowledge, and practices among the rural population of western Maharashtra
    (Medip Academy, 2024-03) Goyal, S.; Salgar, A.; Dhavalshankh, G. G.; Dhavalshankh, G. P.; Dhavalshankh, A. G.
    Background: In India, there is a paucity of population-based studies and data on herpes zoster in reporting herpes zoster cases. Several shreds of evidence reflect that the disease causes a burden on population health in India. Besides several known risk factors, myths, lack of knowledge, attitude, and practices towards treating this infection may affect the quality of life and disease burden. Imparting knowledge, awareness regarding myths and misconceptions, and early approaches for treatment can help prevent disease and complications in the population. Methods: Our study variables were myths about herpes zoster infection, knowledge about herpes zoster infection, and attitudes and practices towards the treatment of herpes zoster infection and to evaluate the impact of health awareness programme on it. It is an interventional study where study population is the families of adopted villages by D.Y. Patil Medical College, Kolhapur from the rural population of western Maharashtra. Results: The awareness programme which was the intervention in this study, was effective in increasing the awareness about myths and knowledge about herpes zoster infection as well as positive impact related to treatment practices for herpes zoster infection among the rural population in the adapted villages in western Maharashtra. Conclusions: The awareness programme which was the intervention in this study, was effective in increasing the awareness about myths and knowledge about herpes zoster infection as well as positive impact related to treatment practices for herpes zoster infection among the rural population in the adapted villages in western Maharashtra.
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    Qualitative analyses of lignocellulolytic enzymes produced by Emericella sp strain HST9 under diverse culture conditions
    (Triveni Enterprises, 2019-11) Tanvi; Goyal, S.; Dhankar, R.; Chaudhary, S.; Nandni; Devi, S
    Aim: Optimization of cultural conditions for improved lignocellulolytic enzyme production by an ascomycete HST9 isolated from leaf and litter waste. Methodology: The fungus HST9 was isolated from leaf and litter waste collected from Chaudhary Charan Singh Haryana Agricultural University, Hisar, India. Culture experiments were conducted at different temperature, pH, incubation periods and aeration conditions. Effects of addition of different concentrations of various metal ions, different carbon complexes and nitrogen salts on enzyme production were also studied under submerged culture condition. Enzyme activities were measured by standard protocols using spectrophotometer. Results: HST9 grew well and produced optimum enzymes at 30oC on 7th day of incubation at stationary conditions and pH- 6. Overall enzyme activities decreased after addition of metal salts. Carboxymethyl cellulose (300 mg l-1) and alkali lignin (200 mg l-1) were observed to be the best carbon complexes for cellulolytic and ligninolytic activities. Ammonium sulfate was found to be a better nitrogen source compared to others. Under optimum conditions, different enzyme activities observed were 0.011 IU m l-1 FPase, 0.015 IU ml-1 CMCase, 6.5 IU m l-1 Lac, 57.5 IU m l-1 LiP and 4 IU ml-1 MnP. Molecular phylogenetic analysis of the strain confirmed that strain HST9 showed closeness with genus Emericella. Interpretation: Lignocellulolytic enzyme activity of Emericella isolate HST9 enhanced at optimum culture conditions, signifying that it can be used as a biological agent to degrade lignocellulosic waste.
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    Technical expertise and behavior of the doctor- a major determinant of waiting time of OPD patients
    (Medip Academy, 2023-02) Bansal, C.; Bansal, M.; Narang, M.; Goyal, S.; Bansal, P.
    Background: The study was conducted to understand various factors affecting waiting time spent by the patients in outpatient department (OPD) and to provide recommendations for reducing the waiting time in OPD of the selected hospital. Methods: It was a descriptive cross-sectional pretested questionnaire-based study involving all new 100 consenting patients at OPD recruited into the study using a systematic sampling technique after calculating the sampling interval. Results: The study indicates that 70% of patients were satisfied and only 30% were dissatisfied with the attention given by the OPD staff, cleanliness, attentiveness of doctor but shows great dissatisfaction regarding the waiting time spent by them in the outpatient department. Most of the subjects gave the reason for their satisfaction despite more time because of expertise of the doctor, behavior of the doctor, association of hospital with non-government organizations and insurance companies for free medicine and surgery. The dissatisfaction was not because of lack of administration but because of low level of awareness amongst patients attending the OPD about internet booking of appointment, COVID protocols, priorities given to recommendations given by other doctors/VIPs and walk in OPDs attended without prior appointment. Conclusions: A very important observation which evolved from the study was the version of patients that waiting time does not matter because they want to be treated from same doctor due to his/her expertise. Second important observation was that the addressing and greeting of patient by his/her name gave a great satisfaction and level of comfort to patients and affects the waiting time.