Browsing by Author "Gopinath, P"
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Item Acute effect of nifedipine on left and right ventricular functions in patients with ischaemic heart disease--a radionuclide ventriculography study.(1984-05-01) Wasir, H S; Karloopia, S D; Gopinath, P; Malhotra, A; Mohan, J C; Bhatia, M LItem Acute effect of sublingual nifedipine on right and left ventricular function in patients with chronic cor pulmonale.(1986-11-01) Wasir, H S; Hariharan, V; Malhotra, A; Gopinath, PItem Beneficial effect of oral verapamil on exercise induced silent myocardial ischemia.(1989-03-01) Bajaj, R; Kaul, U; Malhotra, A; Gopinath, P; Bhatia, M LTwelve consecutive patients (all males, age 40-72 years) of asymptomatic angiographically proven coronary artery disease who showed exercise induced regional wall motion abnormalities (RWMA) on Radionuclide Ventriculography were restudied by the same method after 208 weeks treatment with oral Verapamil 240 mg/day. Resting and peak exercise global ejection fractions and RWMA were compared using paired t-test. Without verapamil therapy, the resting mean ejection fraction was 64.75% (SD 9.45%), and fell with exercise (mean fall 5.25%, range - 25% to + 4%). On Verapamil therapy, the resting ejection fraction was 62.75% (SD 8.35%), and rose with exercise (mean rise 1.18%, range - 24% to + 18%). These changes in exercise ejection fractions with and without verapamil therapy were statistically significant (p = 0.01). Four of 5 resting, and 8 of 15 peak exercise induced RWMA improved on therapy. There were no significant differences in resting or peak-exercise double products with and without verapamil. We conclude that oral verapamil improves exercise induced ventricular dysfunction and regional wall motion abnormalities in patients with silent myocardial ischemia.Item Circulatory and respiratory adjustments during severe chronic anaemia.(1971-03-01) Gopinath, P; Shah, P B; Tillu, S B; Shah, C P; Nishith, S DItem Clinical trial on the effect of domperidone on non-ulcer dyspepsia.(1986-06-01) Sarin, S K; Sharma, P; Chawla, Y K; Gopinath, P; Nundy, SItem Effects of aorto-coronary bypass grafting in coronary artery disease on ventricular function: a study at rest and during exercise.(1987-10-01) Shyam Sundar, A; Malhotra, A; Kaul, U; Gopinath, P; Sampath Kumar, A; Sharma, M L; Venugopal, P; Bhatia, M LItem QSAR modeling of isoquinoline derivatives having AKR1C3 inhibitory activity: Lead optimization(Open Science Publishers LLP, 2024-10) Gopinath, P; Ashishranjan, D; Durgaprasad, B; Bidhubhusan, K; Raghuveer, P; RamReddy, G; Rao, KR; Reddy, DR; Subramanyam, S.Aldo-keto reductase 1C3 is a promising drug target for castration-resistant prostate cancer. In the present study, quantitative structure-activity relationship studies were carried out by QSARINS software on 3-(3, 4-dihydroisoquinolin-2(1H)-yl sulfonyl) benzoic acid derivatives having AKR1C3 inhibitory activity. The developed Quantitative Structure-activity relationship (QSAR) model suggests that the descriptors play key roles and are extremely helpful in predicting bioactivity. The best model shows validated statistical values, and residual information predicts the obtained model is robust, stable, and can be utilized to the extent of a novel series of isoquinoline derivatives.Item Radioactive bromide partition test in the diagnosis of tuberculous meningitis.(1983-08-01) Ahuja, G K; Gopinath, P; Sharma, S K; Kalra, VItem Technetium stannous pyrophosphate imaging in acute ischaemic syndromes.(1987-05-01) Radhakrishnan, S; Kaul, U; Malhotra, A; Gopinath, P; Bhatia, M L