Browsing by Author "Goel, A K"
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Item Adjuvant preoperative radiotherapy for resectable rectal cancer. Do we have an answer now?(1998-01-26) Kishore, J; Goel, A KItem Agenesis of gallbladder with choledochal cyst--an unusual combination.(1994-01-01) Goel, A K; Seenu, V; Khosla, N K; Gupta, A; Sarda, A KA case of agenesis of gallbladder associated with Type IVa congenital choledochal cyst is reported. This combination is very rare and a review of literature revealed only three such cases. A brief discussion of gall bladder agenesis with particular reference to associated anomalies is presented. Difficulty in the management of Type IVa choledochal cyst where the extrahepatic and intrahepatic cysts are continuous at the porta, is highlighted.Item Antibacterial study of substituted N-benzylidenediphenylamine-2-carboxylic acid hydrazides.(1975-08-01) Bahadur, S; Goel, A K; Imam, S AItem Bilateral ureteric and renal pelvic invasion by metastatic oesophageal carcinoma (a case report).(1985-10-01) Goel, A K; Rao, M S; Mathur, R P; Vaidyanathan, S; Sen, T K; Suryaprakash, B; Malik, A KItem Bioactivity of marine organisms: Part IX--screening of some marine flora from the Indian coasts.(2006-02-17) Lakshmi, V; Goel, A K; Srivastava, M N; Kulshreshtha, D K; Raghubir, RAlcoholic extracts of 48 identified species of marine flora were screened for a wide range of biological activities. Of these, 3 extracts showed diuretic activity while 2 extracts showed hypotensive effect.Item Bioactivity of marine organisms: Part VI--Screening of some marine flora from Indian coasts.(1992-06-01) Bhakuni, D S; Dhawan, B N; Garg, H S; Goel, A K; Mehrotra, B N; Srimal, R C; Srivastava, M NAlcoholic extracts of 50 botanically identified species of marine flora have been screened for a wide range of biological activities. Of these, 2 extracts exhibited anti-amoebic and antiviral activity each, 3 of them had anti-implantation activity; 9 had hypoglycaemic activity while hypotensive activity was associated with 11 extracts; 14 extracts were found to be diuretic and 1 of them had anti-inflammatory activity. Further, 10 of these extracts exhibited 2 types of activities while a combination of 3 and 4 types of activities was observed in one extract each. Follow-up studies have been carried out in some plants with confirmed activity. The active principles and results of these studies are reported.Item Bioactivity of marine organisms: Part VII--Effect of seaweed extract on central nervous system.(1994-06-01) Kamat, S Y; Wahidulla, S; D'Souza, L; Naik, C G; Ambiye, V; Bhakuni, D S; Jain, S; Goel, A K; Srimal, R CAlcohol extracts of marine algae (Rhodophyceae, Phaeophyceae and Chlorophyceae) were screened for their effect on central nervous system. Of 69 species investigated 8 appeared biologically active, 6 being CNS stimulant and two depressant, sites and dates of collection are given.Item Bioactivity of marine organisms: Part VIII--Screening of some marine flora of western coast of India.(1997-06-01) Siddhanta, A K; Mody, K H; Ramavat, B K; Chauhan, V D; Garg, H S; Goel, A K; Doss, M J; Srivastava, M N; Patnaik, G K; Kamboj, V PMethanolic extracts of 31 botanically identified species of marine flora, collected from Gujarat Coast, have been screened for a wide range of biological activities. Of these, 3 extracts showed anti-implantation, 2 had antiviral, 2 showed hypotensive, 1 had anti-inflammatory while 12 extracts showed diuretic activities. The antiviral activity; against EMCV, was confirmed in one alga. The active principles and results of these studies are reported.Item Bioactivity of marine organisms: part X--screening of some marine fauna from the Indian coasts.(2006-09-27) Lakshmi, V; Goel, A K; Srivastava, M N; Raghubir, RamMethanolic and chloroform-methanol extracts of 25 identified species of marine fauna have been screened for a wide range of biological activities. Of these, 2 extracts exhibited diuretic activity, while antibacterial, antiviral, oxytocic and spasmolytic activities, were observed in 1 extract each.Item The biological role of carcinoembryonic antigen.(1993-10-01) Seenu, V; Goel, A KItem Botulinum toxin in the management of anal fissure: innovative use of a familiar agent.(1995-01-01) Goel, A K; Seenu, VItem Breast cancer presentation at a regional cancer centre.(1995-01-01) Goel, A K; Seenu, V; Shukla, N K; Raina, VBACKGROUND. Breast cancer accounts for 20% of all female cancers in India and most patients present with advanced disease. Many factors may be responsible for the late presentation including the prehospital diagnostic and therapeutic approach towards breast lumps which may be malignant. To evaluate these factors we carried out a prospective investigation at the Institute Rotary Cancer Hospital of the All India Institute of Medical Sciences. METHODS. We studied 100 new patients with breast cancer seen in a special clinic over a 12-week period, excluding patients who did not have a palpable lump and those who had had an operation in another hospital more than six months previously. RESULTS. Fifty-seven of the patients were from urban and 43 from rural areas. Only 20 patients were aware of breast cancer before the onset of their illness. They were mainly from an urban background, educated and had a family history of breast and other malignancies. The total duration of illness ranged from 1 week to 10 years (mean 11.3 months) and the time to first visit ranged from 1 day to 9.5 years (mean 6.7 months). The delay between the first contact with a doctor to the date seen in the Institute Rotary Cancer Hospital thus amounted to a mean of 4.6 months. The duration of illness as well as time to first visit was also significantly shorter in urban patients, those who were educated and those who were aware of the disease. Fine needle aspiration cytology was used in 50 patients and was diagnostic in 39. Thirty of the 100 patients had no diagnostic investigations. Of the 43 patients treated elsewhere, the operation had been inadequate in 17 and 27 of the 43 patients were found to have had faulty adjuvant therapy. Many patients did not carry their operation notes and histopathology reports and when these were available, they were often of poor quality. The use of staging investigations was incomplete so much so that in 22 patients the disease could not be staged at all because of poor records. CONCLUSION. Breast cancer is seen in our hospital in an advanced stage because most patients are unaware of the disease. However, the treating physician also contributes to delay in the diagnosis, uses the diagnostic and staging investigations improperly, performs inadequate surgery and prescribes inappropriate adjuvant treatment. Record keeping is also of a poor quality. We need to provide more information to both patients and doctors about breast cancer.Item Breast cancer--do we need to change the model?(1994-01-01) Goel, A K; Seenu, VItem Circadian desynchronization in pulse rate, systolic and diastolic blood pressure, rectal temperature and urine output in traumatic tetraplegics.(1985-10-01) Goswami, R; Krishan, K; Suryaprakash, B; Vaidyanathan, S; Rao, K; Rao, M S; Goswami, A K; Goel, A K; Sharma, P LAn investigation was undertaken to study the circadian rhythmicity in pulse rate, systolic and diastolic blood pressure, rectal temperature and urine output in eight traumatic tetraplegics in view of the fact that diurnal rhythmicity in prolactin response to thyrotropin-releasing hormone was absent in such patients. The data, analysed by single cosinor procedure, showed absence of rhythmicity in all five parameters. Analysis of variance also showed no significant difference in these parameters at various time points. Knowledge of the alterations in circadian biology subsequent to cervical spinal cord trauma would provide useful guidelines towards chronotherapy and vocational rehabilitation of tetraplegics besides possible restoration of euchronism by pharmacological means.Item Complications of laparoscopic cholecystectomy.(1992-10-01) Goel, A K; Seema, VItem Delayed stoma closure improves prognosis in colorectal cancers?(1995-04-01) Goel, A K; Seenu, VItem Development & validation of a quantitative anti-protective antigen IgG enzyme linked immunosorbent assay for serodiagnosis of cutaneous anthrax.(2015-08) Ghosh, N; Gunti, D; Lukka, H; Reddy, B R; Padmaja, Jyothi; Goel, A KBackground & objectives: Anthrax caused by Bacillus anthracis is primarily a disease of herbivorous animals, although several mammals are vulnerable to it. ELISA is the most widely accepted serodiagnostic assay for large scale surveillance of cutaneous anthrax. The aims of this study were to develop and evaluate a quantitative ELISA for determination of IgG antibodies against B. anthracis protective antigen (PA) in human cutaneous anthrax cases. Methods: Quantitative ELISA was developed using the recombinant PA for coating and standard reference serum AVR801 for quantification. A total of 116 human test and control serum samples were used in the study. The assay was evaluated for its precision, accuracy and linearity. Results: The minimum detection limit and lower limit of quantification of the assay for anti-PA IgG were 3.2 and 4 μg/ml, respectively. The serum samples collected from the anthrax infected patients were found to have anti-PA IgG concentrations of 5.2 to 166.3 μg/ml. The intra-assay precision per cent CV within an assay and within an operator ranged from 0.99 to 7.4 per cent and 1.7 to 3.9 per cent, respectively. The accuracy of the assay was high with a per cent error of 6.5 - 24.1 per cent. The described assay was found to be linear between the range of 4 to 80 ng/ml (R2=0.9982; slope=0.9186; intercept = 0.1108). Interpretation & conclusions: The results suggested that the developed assay could be a useful tool for quantification of anti-PA IgG response in human after anthrax infection or vaccination.Item Early oral feeding after elective colorectal surgery: is it safe.(1995-10-01) Seenu, V; Goel, A KThe authors have carried out a prospective trial to assess the safety, tolerability and outcome of early resumption of oral feeding after elective abdominal surgery involving the small or the large bowel. Over the study period, 161 patients undergoing elective laparotomy and bowel resection were randomized to two groups. Patients undergoing laparoscopic surgery were not included. In both groups, the nasogastric tube was removed immediately after surgery. In group I, oral feeding was started on first postoperative day, beginning with clear fluids and gradually progressing to a normal diet over a period of 24 to 48 hours, as tolerated. In group II, oral feeding was started after resolution of postoperative ileus, starting again with clear fluids as in group I. The resolution of postoperative ileus was defined as having bowel movements with no abdominal distention or vomiting. In both groups, nasogastric tube was reinserted if the patient had two episodes of vomiting of more than 100 ml over 24 hours in the absence of bowel movements. Postoperative analgesia was similar in both groups and same criteria for discharge from the hospital were followed. Of the 161 patients, 80 were in the early feeding group and 81 in the other group. The age and sex distribution of the patients in both groups was similar. In both groups, segmental colonic, rectal or small bowel resection was the commonest surgery. In group I, 79% patients tolerated feeds compared to 86% in group II. The incidence of vomiting was thus 21% in group I and 14% in group II, the difference being statistically insignificant. Reinsertion of nasogastric tube was required only in 11% patients in group I and 10% patients in group II. Further, the length of postoperative ileus (3.8 + 0.1 vs 4.1 + 0.1 days), length of hospital stay (6.2 + 0.2 vs 6.8 + 0.2 days) and incidence of complications (7.5% vs 6.1%) were not significantly different between the two groups. However, regular diet was tolerated significantly earlier. (p <0.001) in group I as compared to group II (2.6 + 0.1 vs. 5.0 + 0.1 days). Further, there was no incidence of anastomotic leaks or aspiration pneumonia, complications which could be expected to occur secondary to early feeding. The authors have reviewed the literature which shows a trend towards decreasing use of routine postoperative nasogastric drainage. Based on the results of the current study, they suggest that there is no need to delay oral feeding till resolution of colonic ileus as early feeding is safe and well tolerated. They also suggest that early resumption of oral feeding may have a positive impact on the psychological state of the patient and may help the recovery.Item Effective control of chemotherapy induced vomiting--arrival of a new class of drugs.(1993-10-01) Goel, A K; Seenu, VItem Esophageal bezoar: a rare but distinct clinical entity.(1995-01-01) Goel, A K; Seenu, V; Srikrishna, N V; Goyal, S; Thakur, K K; Shukla, N KA 89 year old female patient presented with severe dysphagia and was suspected to have carcinoma of the esophagus. Endoscopy revealed an esophageal phytobezoar which passed down spontaneously after unsuccessful endoscopic extraction attempt. Barium swallow study revealed diffuse spasm of the esophagus. A review of English literature revealed only 17 previous cases of esophageal bezoar. Salient features of esophageal bezoars are discussed based on previous reports and the current case.
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