Browsing by Author "Ghosh, T K"

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    AIDS: a serious challenge to public health.
    (1986-01-01) Ghosh, T K
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    Argyrophilic nucleolar organiser regions (AgNORs) in breast lesions.
    (1997-09-08) Dasgupta, A; Ghosh, R N; Sarkar, R; Laha, R N; Ghosh, T K; Mukherjee, C
    Nucleolar organiser regions (NORs) demonstrated by argyrophilia of NOR-proteins are indicator of cellular proliferative activity. The NORs can be identified in the nuclei as brown or black dots with silver colloidal staining technique in formalin fixed paraffin sections and in cytology smears. Seventy-five cases including 45 tissue sections and 30 fine needle aspiration cytology (FNAC) smears of benign and malignant lesions of breast have been studied to evaluate the significance and practical application of AgNOR count per nucleus. Out of 45 tissue sections 15 belonged to fibrocystic disease, 10 fibro-adenomas and 20 carcinomas and of the 30 FNAC smears, 10 were fibrocystic disease, 8 fibro-adenomas and 12 carcinomas. In fibrocystic disease the mean AgNOR count was 1.60 (FNAC group-0.75, tissue section-1.61). In fibro-adenomas it was 1.61 (FNAC-1.63, tissue section-1.59). The mean count in carcinoma was 12.10 (FNAC-12.08, tissue section-12.10). The difference in AgNOR count in fibrocystic disease and fibro-adenoma was not significant, but that between benign breast lesion and carcinoma was significant. No difference was observed between FNAC and tissue section groups in benign or malignant lesions. The simple staining technique can be used as an additional criterion to differentiate the benign and malignant lesions of breast.
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    articleEarly diagnosis of neonatal sepsis in primary health care unit.
    (2015-04) Sarkar, A P; Dhar, G; Sarkar, M D; Ghosh, T K; Ghosh, S
    Aim: The aim of the study is to find out the role of common haematological parameters along with micro-ESR, I/T ratio in diagnosis of neonatal sepsis for initiating early management. Methods: This is a descriptive study consisting of 35 neonates admitted at a sophisticated institute with clinical suspicion of septicaemia along with 40 neonates as the comparison group. The neonatal haematological parameters including total leucocytes count, absolute neutrophil count, immature neutrophil count, I/T ratio, platelet count were measured in all the neonates. Micro-ESR was measured as a bed side test. CRP was also measured using slide agglutination method and the results were compared with turbidimetric method. Blood culture was done as a gold standard test for sepsis. Micro-ESR more than age of the patient in days +3 mm in 1st hour was considered significant for sepsis. I/T ratio more than or equal to 0.2 was considered positive for sepsis. Results: The study revealed that micro-ESR and I/T ratio were significantly higher (p<0.001) in suspected cases of septicaemia as compared to the neonates in the comparison group. Sensitivity and specificity of micro-ESR were 87.09% and 75.0% respectively. Sensitivity and specificity of I/T ratio were 93.54% and 95% respectively. Conclusion: Micro-ESR and I/T ratio can be used effectively as cheap and simple tests to screen for septicaemia in neonate which is possible even in a primary health care centre.
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    Bilateral tubercular abscess of breast in axillary tail in a 21 year old puerperal lady.
    (2011) Karmakar, A; Ghosh, S; Dewasi, N; Ghosh, T K
    Tuberculosis is a very common disease in the Indian subcontinent. Though it can affect any system of the body, primary involvement of the breast is relatively rare even in India. Involvement of the axillary tail is even rarer. Bilateral involvement is also a rare phenomenon (3%). Moreover the disease is often overlooked and misdiagnosed as carcinoma or pyogenic abscess. Here we report a case of bilateral tubercular abscess of breast in the axillary tail in a 21 year old puerperal lady diagnosed by FNAC and AFB stains and further confirmed retrospectively by response to anti-tubercular drugs.
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    C - reactive protein levels in women with pregnancy induced hypertension.
    (2011) Ghosh, T K; Ghosh, S; Bhattacharjee, D
    Objective: The main objective of this study is to determine the level of C- reactive protein in pregnancy induced hypertension (PIH) along its relation with normal pregnant mothers and also to compare it with different grades of pregnancy. C-reactive protein and inflammation are interrelated. Another objective of this study is to find out the relationship of C- reactive protein, biochemical and hematological parameter in PIH as well as its clinical correlation. Materials and Methods: The study was conducted in the department of Gynaecology and department of Pathology in Burdwan Medical College West Bengal India after taking permission from ethical committee. 50 cases of PIH mothers and age and gestational matched 50 cases of normal control pregnant mothers and 50 normal healthy non pregnant adult women were included in this present study. CRP was estimated by turbidometric method. Serum Uric acid, SGPT, Serum Creatinine were estimated by semi auto analyzer, Serum ß HCG was estimated by ELISA technique. The total leukocytes count, absolute Neutrophils count, Platelet counts were done in hematological cell counter with correlation from peripheral direct smear and manual counting. Urine protein was detected by dipstick method. Results: Serum C- reactive protein was positively correlated with severity of in PIH. Results shows a significantly increased C-reactive protein in PIH (Mean SD 42.02 mg/L±18 .01 mg/L, P<0.001) in comparison to normal control mother (Mean SD 4.2 ±0.93 mg/L). Conclusion: Serum C-reactive protein levels can be used as marker for early diagnosis and intervention of PIH and can be reduced maternal as well as fetal morbidity and mortality.
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    Epidemiology of bancroftian filariasis in a semi-urban community of Kerala State.
    (1989-12-01) Jain, D C; Menon, P K; Sethumadhavan, K V; Johney, V M; Ghosh, T K
    A community-based longitudinal study was initiated in 1983 in a semi-urban area, endemic for bancroftian filariasis to determine the incidence and prevalence, natural history and clinical pattern of filarial infection and also to study the impact of control measures on it. The base-line filariometric indices observed during the initial clinico-parasitological survey and entomological observations made during the first 12 months of this study are highlighted in this paper. 5.5 per cent of the examined population had microfilaraemia with average infestation of 8.1 per 20 cmm. The microfilaraemia found to have significant (P less than 0.001) relationship with age, but not with sex (P greater than 0.05). The filarial disease which had the prevalence of 3.6 per cent showed a significant (P less than 0.001) relationship to both age and sex. The youngest microfilaria (mf) carrier was of 2 years and with filarial swelling was of 6 years age. A significant (P less than 0.001) relationship of educational status and family size was observed with disease while it was non-significant (P greater than 0.05) with microfilaraemia. With the increase in per capita income of the individuals, a significant decrease in number of persons with microfilaraemia (P less than 0.01) as well as with disease (P less than 0.05) was noted. Culex quinquifasciatus, the vector for this infection was prevalent throughout the period of observation with highest density in September. Vector infection and infectivity rates ranged from 0 to 4.4 per cent and 0 to 2.2 per cent respectively.
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    Epidemiology of brugian filariasis in a rural community of Kerala State.
    (1989-03-01) Jain, D C; Chandrasekharan, A; Sethumadhavan, K V; Johny, V M; Cherian, C; Ghosh, T K
    The baseline clinico-parasitological parameters collected during the initial survey and the entomological observations made during the first year as a part of a longitudinal study undertaken in a brugian endemic rural community are presented in this paper. Out of the total (11.604) examined population, 8.1 per cent had microfilaraemia and 7.6 per cent had filarial disease. A highly significant (P less than 0.001) relationship of age was observed with microfilaraemia and the disease. The filarial disease rate showed no significant difference between two sexes while the microfilaria (Mf) rate was significantly (P less than 0.001) higher in males than females. A significant (P less than 0.001) relationship of microfilaraemia as well as of filarial disease was found with the income and the educational status of the individual. The mf and the disease rates did not differ by the family size except those families with 1-3 members. However, the relationship of family size was found to be significant (P less than 0.001) with disease and non-significant (P greater than 0.05) with microfilaraemia. The vectors were prevalent throughout the year but the infection was mostly confined to Mansonia annulifera.
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    Epidemiology of veno-occlusive disease in tribal population of Madhya Pradesh and Bihar.
    (1981-09-01) Arora, R R; Pyarelal,; Ghosh, T K; Mathur, K K; Tandon, B N
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    Experience with telepathology at a tertiary cancer centre and a rural cancer hospital.
    (2004-01-30) Desai, Sangeeta; Patil, Rajasa; Chinoy, Roshni; Kothari, Ashok; Ghosh, T K; Chavan, Manoj; Mohan, Ashok; Nene, B M; Dinshaw, K A
    BACKGROUND: Telepathology allows quick and timely access to an expert opinion, no matter where the patient is located. We analysed the experience with the use of telepathology between a tertiary cancer centre and a rural cancer hospital. METHODS: Ninety-three cases were analysed in which static telepathology was used to obtain a consultation between Tata Memorial Centre and Nargis Dutt Memorial Cancer Hospital at Barshi, a rural area. RESULTS: Successful teleconsultation was achieved in all cases. A diagnosis was offered in 92 cases (98.9%) and was deferred in 1 case (1.1%). Complete concordance, clinically unimportant minor discrepancy and hedged diagnosis were obtained in 83 cases (90.2%). Major discrepancies were encountered in 9 cases (9.7%). The number of images per case ranged from 3 to 27 (average: 7 images). Images were of diagnosable quality in 89.2% of cases. Most of the cases (77.4%) were reported within 3 days; 32.2% were reported within 8 hours (a single working day) and 45.1% within 1-3 days. CONCLUSION: Telemedicine can be effectively used to bridge the gap between medically underprivileged, geographically distant rural areas and advanced centres using the static store and forward methodology.
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    Factor influencing acceptance and non-acceptance to DEC in a bancroftian endemic area.
    (1986-12-01) Sunny, P J; Jain, D C; Sorrian, T P; Ghosh, T K
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    Feasibility of controlling lymphatic filarial diseases through primary health care system.
    (1989-06-01) Patnaik, S K; Narasimham, M V; Ghosh, T K; Rao, C K; Kaur, R; Narayana, M V
    A study was undertaken to explore the feasibility of treatment of clinical cases of filariasis by the Village Health Guides (VHG) and to assess the impact of different dose schedules by Diethylcarbamazine (DEC) on the frequency of acute attacks. It was observed that six days treatment with DEC at a dose of 500 mg daily was the most effective regimen in controlling recurrence of filarial attacks. The VHGs can serve the community in treating filarial cases with DEC.
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    "Global environmental problems".
    (2008-03-04) Ghosh, T K
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    Glucose oxidase-induced lysis of erythrocytes.
    (1995-01-01) Sen, T; Ghosh, T K; Chaudhuri, A K
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    Glycaemic effects of tentacle extract of the jellyfish Acromitus rabanchatu (Annandale).
    (1990-05-01) Ghosh, T K; Gomes, A; Nag Chaudhuri, A K
    Tentacle extract of the common jellyfish A. rabanchatu, caused glycaemic alteration in fasting rabbits. Intravenous administration of the extract produced a significant rise followed by a significant fall in blood sugar level. Glucose tolerance in rabbits was also significantly increased. Extract-mediated hypoglycaemic response was fully abolished in alloxan diabetic rabbits. Preliminary separation on Sephadex G 50 indicated the hypoglycaemic factor to be a non-lethal protein of molecular weight less than 20 kDa. Heat treatment of extract and G 50 separated fraction P2 demonstrated total loss of hypoglycaemic activity.
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    Immunogenicity and safety of live attenuated hepatitis A vaccine: a multicentric study.
    (2009-01-31) Faridi, M M A; Shah, Nitin; Ghosh, T K; Sankaranarayanan, V S; Arankalle, Vidya; Aggarwal, Anju; Sathiyasekaran, Malathi; Bhattacharya, Nisha; Vasanthi, T; Chatterjee, Suparna; Choudhury, Jaydeep; Mitra, Monjori
    OBJECTIVE: To evaluate immunogenicity and tolerability of single dose live attenuated injectable hepatitis A vaccine in four metropolitan cities of India. METHODS: Live attenuated hepatitis A vaccine was administered to 505 children aged 18 to 60 months in four centers across India. Immunogenicity of the vaccine was assessed by estimation of anti-HAV antibody titer at 6 weeks and 6 months following administration of the vaccine. Safety evaluation of the vaccine was also done during the visits. RESULTS: At 6 weeks, 480 subjects (95%) came for the follow-up and 411 (81.4%) subjects reported at the end of 6 months. The geometric mean titer (GMT) of anti-HAV antibody of the subjects who did not have the seroprotective titer at the baseline were assessed at 6 weeks and 6 months which was 81.04 mIU/ml and 150.66 mIU/ml respectively. At 6 weeks, 95.1 % seroconverted and at the end of 6 months, 97.9 % had seroconverted. Both solicited and unsolicited vaccine-induced local and systemic adverse events were insignificant at all the centers, except swelling and induration in a few. CONCLUSION: Live attenuated injectable hepatitis A vaccine was immunogenic and tolerable with minimal reactogenecity, in this study of single dose schedule. Safety profile was also satisfactory in the study population.
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    Immunological studies in human filariasis.
    (1985-03-01) Santhanam, S; Malhotra, A; Kumar, H; Ghosh, T K
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    In vitro maintenance and development of Wuchereria bancrofti microfilariae.
    (1986-12-01) Kumar, H; Malhotra, A; Santhanam, S; Ghosh, T K