Browsing by Author "Garg, Pankaj"
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Item Acanthameba meningitis with successful outcome.(2009-10) Saxena, Ajit; Mittal, Sumit; Burman, Purbi; Garg, PankajWe report a rare cause of sub acute meningitis in a 15-yr-old immunocompetent female child with successful outcome. The etiological agent was Acanthameba. The child was sucessfully treat with combination of Ketoconazole. Rifampicin, cotrimoxa zole and for a period of 9 month.Item Arthritis in HIV.(2005-04-07) Garg, PankajItem Cerebro-oculo-facio-skeletal syndrome in a neonate.(2002-08-28) Mathur, N B; Alwadhi, R K; Garg, PankajItem Dengue, HIV and thrombocytopenia.(2008-11-24) Garg, Pankaj; Seneviratne, Suranjith LItem Do we need to use nitric oxide in preterm babies in developing countries?(2006-03-11) Garg, PankajNeonatal care in developing nations is advancing rapidly. There is an increasing tendency to include nitric oxide in the therapeutic armamentarium. But the opinion regarding its use remains divided among neonatologists even in the western world. Nitric oxide has an established role in the management of persistent pulmonary hypertension in term neonates. However, the use of nitric oxide in preterm neonates has been controversial and the Cochrane review updated in 2001 did not give conclusive answers. There have been adequately powered multi-centre trials recently on the issue, planned to resolve the controversy. The present communication highlights the salient features and conclusions drawn from these trials.Item Endo-light pipe to localise the site of SRF drainage in retinal reattachment surgery with hazy ocular media.(2002-09-03) Kumar, Atul; Prakash, Gunjan; Garg, PankajItem Evaluation of an algorithm for persistent/ chronic diarrhea in children at a community hospital adjoining slums in Agra, north India.(2006-05-24) Garg, PankajThe objective of this study was to evaluate an algorithm for the management of children with persistent/chronic diarrhea at a community level hospital. The study was carried out in the pediatric OPD of a 150 bed trust hospital catering to children from poor, rural and urban slums. Fifty clinically stable children (6 months-5 years old, mean = 19.7 months) with persistent or chronic diarrhea refusing admission, being managed on an outpatient basis, were enrolled prospectively. A detailed history and physical examination were done for each child to ascertain the cause of diarrhea. They were managed using a pre-tested simplified algorithm and monitored for symptom improvement using a questionnaire 15 days, 1 month and 3 months after initiation of therapy. The average cost for treatment of each child was also calculated. Twenty-one (42%) children had persistent diarrhea. Seven (14%) infants with a typical history of lactose malabsorption responded to a trial of WHO feeding protocols or lactose/sucrose free milk. Four (8%) infants had chronic non-specific diarrhea. A total of 71.8% (28/39) of children were treated satisfactorily with albendazole or metronidazole and Cotrimaxazole along with hematinics and multivitamins. Three (6%) children were diagnosed with abdominal tuberculosis. Four (8%) had raised anti-tissue tranglutaminase antibodies (age 18-34 months). The algorithm used was successful in managing all the children with chronic diarrhea. The average cost per managed case was US$10. Further, multi-center evaluations of similar algorithms are needed to validate the observations in the present study.Item Experience in counselling downs syndrome.(2007-08-11) Garg, PankajItem Growth of Very Low Birth-Weight Indian Infants During Hospital Stay.(2010-10) Saluja, Satish; Modi, Manoj; Kaur, Avneet; Batra, Anil; Soni, Arun; Garg, Pankaj; Kler, NeelamObjectives: To evaluate the growth pattern of Very Low Birth Weight (VLBW) infants (birthweight <1500g) during hospital stay and to compare the growth of Small for gestational age (SGA) and Appropriate for gestational age (AGA) infants. Study design: Prospective observational study. Setting. Level III Neonatal Intensive Care Unit (NICU) in Northern India. Participants: A cohort of 97 VLBW infants, admitted to NICU at Sir Ganga Ram Hospital, from 1 January, 2007 to 31 July, 2008. Intervention/Measurement: Weight, length and head circumference (HC) were serially measured from birth till discharge and respective Z scores were calculated as per data from Fenton’s references. Growth was also assessed by superimposing these trends on Ehrenkranz’s postnatal growth charts. Results: The mean Z scores for weight, length and HC at birth were –1.17, –1.09 and –0.54, respectively. These decreased to –2.16, –2.24 and –1.35, respectively by discharge. Both SGA and AGA infants exhibited a decrease of approximately 1 Z score in all parameters. On postnatal charts, growth of infants remained at or above respective reference lines, except in those below 1000g at birth. Average daily weight gain after regaining birth weight was 15.18 ± 1.7 g/kg/d, whereas the increase in HC and length were 0.48 ± 0.2 cm/week and 0.60 ± 0.4 cm/week, respectively. These increments when compared to the intrauterine growth rates, indicated discrepant growth trends. Conclusions: VLBW infants suffered significant growth lag during NICU stay and exhibited disproportionately slow growth of HC and length.Item Impact of Quality Improvement Program on Expressed Breastmilk Usage in Very Low Birth Weight Infants(Indian Academy of Pediatrics, 2018-09) Thakur, Anup; Kler, Neelam; Garg, Pankaj; Singh, Anita; Gandhi, PriyaObjective: To improve the usage of expressed breast milk invery low birth weight infants admitted in the neonatal intensivecare unit of a tertiary centre in India.Methods: Between April 2015 and August 2016, various Plan-do-act-study cycles were conducted to test change ideas likeantenatal counselling including help of brochure and video, post-natal telephonic reminders within 4-6 hours of birth,standardization of Kangaroo mother care, and non-nutritivesucking protocol. Data was analyzed using statistical processcontrol charts.Results: 156 very low birth weight infants were deliveredduring the study period, of which 31 were excluded due tovarious reasons. Within 6 months of implementation, theproportion of very low birth weight infants who receivedexpressed breast milk within 48 hours improved to 100% from38.7% and this was sustained at 100% for next 8 months. Themean time of availability and volume of expressed breast milkwithin 48 hours, improved gradually from 73.3 h to 20.9 h and 4.7mL to 15.8 mL, respectively. The mean proportion of expressedbreast milk once infant reached a feed volume of 100 mL/kg/dayalso improved from 61.3% to 82.3%.Conclusion: Quality improvement interventions showedpromising results of increased expressed breast milk usage invery low birth weight infants.Item Infantile colic--unfolded.(2004-10-09) Garg, PankajInfantile colic is a common complaint for which mothers bring their babies to pediatricians. Though the condition has been a cause of controversy and a subject of extensive research, no consensus is yet reached on its definition, etio-pathogenesis and management. This article reviews the existing literature on present subject.Item Irrational use of anti-tubercular therapy.(2005-08-01) Garg, PankajItem Mosquito coil (Allethrin) poisoining in two brothers.(2004-11-14) Garg, Pankaj; Garg, PrahladItem Neonatal survival in India thinking beyond resource limitations.(2008-06-05) Garg, PankajItem Neonatologist’s Viewpoint.(2014-04) Garg, PankajItem Neonatology in developed and developing nations.(2007-02-06) Garg, Pankaj; Bolisetty, SrinivasNeonatal care has made tremendous improvements in developing countries. However there are number of challenges to be met and neonatal mortality remains unacceptably high. In contrast to this neonatal care in developed nations have moved ahead of a pre-occupation to reducing the neonatal mortality only. The main reasons for this gap are poor infrastructure, resource limitations and lack of systems developed by neonatal units in the developed nations. Though this communication we explore the possibilities of application of health policies in the Australian neonatal units in developing countries.Item NICU in a community level hospital.(2005-01-03) Garg, Pankaj; Krishak, Rajeev; Shukla, D KOBJECTIVE: To study the clinical profile and outcome of neonates in NICU of a community hospital and highlight the importance and problems in neonatal care at a community level hospital. METHODS: Retrospective analysis of case records during the period Jan. 2001- Dec. 2003. Data regarding antenatal care, maternal morbidity, place of birth, age at admission, birth weight, gestational age, diagnosis, relevant investigations, duration of stay and outcome were recorded on a preset proforma. A cost analysis for average expenses per newborn per day for different morbidities was also done. Neonatal data was analyzed among survivors and expired using appropriate statistical tests. Probability of less than 5% was taken significant. Factors found significant on univariate analysis were subjected to logistic regression model to study independent predictor of fatality. RESULTS: A total of 168 neonates were admitted during the study period. The overall survival rate was 65%. 42(25%) neonates expired and 5.4% were referred to higher centers. The commonest morbidity in survivors was hyperbilirubinemia. Prematurity with HMD and neonatal sepsis were the commonest cause of mortality. 36(24.3%) expired within 48 hr of admission (Mean 33.2 hr). 31(17.8%) could not be referred and none survived. The difference of birth weight, gestational age and duration of stay was statistically different in survivors & expired. These variables retained their significance on multivariate analysis and thus were independent predictors of fatality. An average expense of Rs 400-500/day/newborn was charged in the NICU. CONCLUSION: In a country of limited resources, 65 % neonates requiring NICU can be managed at community level hospitals.Item Normative Data of Optimally Placed Endotracheal Tube by Point-of-care Ultrasound in Neonates(Indian Academy of Pediatrics, 2019-05) Singh, Poonam; Thakur, Anup; Garg, Pankaj; Aggarwal, Neeraj; Kler, NeelamObjective: To derive normative data of the distance betweenoptimally placed endotracheal tube tip and arch of aorta byultrasound in neonates across different weight and gestation.Design: Cross-sectional study.Setting: Tertiary care neonatal intensive care unit from April 2015to May 2016.Participants: All neonates requiring endotracheal intubation wereeligible for the study.Methods: During intubation, insertional length was determinedusing weight-based formula. The distance between endotrachealtube tip and arch of aorta was measured by ultrasound.Endotracheal tube position was confirmed by chest radiograph.Results: Out of 133 enrolled infants, 101 (75.9%) had optimallyplaced endotracheal tubes. The mean (SD) distance betweenendotracheal tube tip and arch of aorta by ultrasound was 0.78(0.21) cm in infants <1500 g and 1.04 (0.32) cm in infants ≥1500 g.The regression equation to estimate insertional length fromweight, crown heel length (CHL), occipito-frontal circumference(OFC), nasal tragus length (NTL) and sternal length (SL) wereWt(kg)+4.95, 0.15×CHL(cm)+0.57, 0.22×OFC(cm)+0.49, 0.82×NTL(cm)+1.24 and 0.75×SL(cm)+2.26, respectively.Conclusion: Our study reports normative data of the distancebetween optimally placed endotracheal tube tip and arch of aortaby ultrasound in neonates. The distance between endotrachealtube tip and arch of aorta increases with increase in weight andgestation. Insertional length correlates strongly with all theanthropometric parametersItem Pediatric hospitalizations at two different setting community hospitals in north India: Implications for regionalization of care.(2009-07) Garg, PankajObjective. To evaluate pediatric hospitalizations at two different setting community hospitals in north India, and to understand the implications for regionalization of pediatric care in heterogeneous environment of India. Methods. Retrospective review of medical records of children hospitalized at a large and a small community hospital catering to population from different social classes but in close proximity to each other was carried out. Baseline characteristics and diagnosis were recorded, and compared using appropriate statistical tests. Results. There were notable differences between the age and morbidity profiles at the two study hospitals. Smaller community hospital catered to more young, malnourished and sicker children. Morbidity profile comprised of significantly more acute gastroenteritis and communityacquired pneumonia at the small hospital. In contrast, almost a quarter (24.4%) of children was injured at the larger community hospital. Infants and newborns were more at small, while older children (>5yrs) were more at the larger community hospital (p<0.0001). Conclusion. The conclusion drawn from this study is that significant differences exist in age and morbidity profiles between different setting community hospitals in north India. There is a need to form a prospective registry of community hospitals, which would validate the observations of the present study, and has implications for regionalization of specialized pediatric services as well as postgraduate training in India.Item Predictors of fatality in neonates requiring mechanical ventilation.(2005-07-09) Mathur, N B; Garg, Pankaj; Mishra, T KOBJECTIVE: To evaluate initial arterial blood gas, pulmonary pressures, pulmonary mechanics (compliance and resistance), pulmonary volumes, oxygenation indices and serum carotenoid levels as predictors of fatality in mechanically ventilated neonates. DESIGN: Cross Sectional. SETTING: Referral neonatal unit of a teaching hospital. SUBJECTS: 83 mechanically ventilated outborn neonates. METHODS: 83 neonates consecutively put on mechanical ventilator from March to December 2001 were enrolled in the study. The mechanical ventilator used was pressure limited time cycled ventilator with facility for online measurement of volumes and pulmonary mechanics. Arterial blood gas after half an hour of initiation of mechanical ventilation and initial pulmonary pressures, pulmonary compliance, resistance and duration of mechanical ventilation were recorded in a pre structured proforma. Initial serum carotenoid levels were also measured using spectrophotometric method. The neonates were regularly followed up for outcome. Multiple logistic regression analysis was done to find out the predictors of fatality for those variables that were significantly associated with outcome on univariate analysis. RESULTS: On univariate analysis weight ( < 2000 g), gestational age <34 weeks, pH <7.3, duration of mechanical ventilation <72 hours, a/A <0.25, compliance <1 mL/cmH2O, fraction of inspired oxygen (FiO2) >60%, oxygenation index >10, AaDO2 >250 and serum carotenoid levels < 100 microg/dL were significantly associated with fatality in neonates requiring mechanical ventilation. However, on multiple regression analysis only FiO2, gestational age and serum carotenoids < 100 microg/dL were found to be independent predictors of fatality. CONCLUSIONS: Initial FiO2 > 60%, gestational age <34 weeks and initial serum carotenoid levels < 100 microg/dL were independent predictors of fatality in neonatal mechanical ventilation. Even in a setting with high fatality rates, high risk of mortality in mechanically ventilated neonates can be identified.