Browsing by Author "Garg, P"

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    Accidental poisoning.
    (1994-12-01) Khadgawat, R; Garg, P; Bansal, P; Arya, A; Choudhary, B
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    Acute secretory traveller's diarrhoea caused by Vibrio cholerae which does not belong to the O1 or O139 serogroup.
    (1998-09-21) Bhattacharya, M K; Dutta, D; Deb, A; Garg, P; Chakraborty, S; Mukhopadhyay, A K; Bhattacharya, S K; Moitra, A
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    Agenesis of frontal bone.
    (1992-01-01) Sharma, N K; Garg, P; Gupta, A K
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    Alkaptonuria: early detection.
    (1994-05-01) Khadagawat, R; Teckchandani, R; Garg, P; Arya, A; Choudhary, B
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    Angiomyolipoma of kidney.
    (1992-09-01) Marya, S K; Singh, M; Garg, P; Jain, K; Sharma, R
    Angiomyolipoma is an uncommon benign tumour accounting for less than 1% of all surgically excised tumours of the kidney. It may present as an isolated lesion or in association with tuberous sclerosis. An impalpable tumour is often detected incidentally during investigation of a case for some urinary tract pathology. CT scan has proved to be a useful investigation for pre-operative diagnosis; it may however, be of no value if the fat content of the tumour is low. Here a case of angiomyolipoma of left kidney is reported where pre-operative diagnosis was suggested by CT scan and histopathology confirmed it.
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    Assessment of intravenous streptokinase therapy in acute myocardial infarction.
    (1993-06-01) Garg, P; Saigal, R; Mathur, S C
    Ten patients presenting within 6 hours of myocardial infarction, without contraindication for thrombolytic therapy, were given intravenous (IV) streptokinase (STK) 750,000 units in 15-30 min by infusion followed by anticoagulant therapy. Treatment was started within 241-360 min after the onset of symptoms. Fifteen other patients were given standard treatment without STK. Reperfusion was observed after a mean duration of 46 min in 7 patients in the STK group and none in the non-STK group. The results of IV STK thrombolytic therapy are comparable with those of previous studies using IV STK.
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    Assessment of Knowledge, Attitude and Practice of Pharmacovigilance among the Interns in a Tertiary Care Hospital in Northern India-A Questionnaire Based Study
    (Dr. J.S. Sodhi Memorial Educational Society, 2017-02) Garg, P; Sharma, V; Bajaj, J K
    Background: The use of drugs and occurrence of its ADRs go hand in hand. Spontaneous reporting of ADRs is an effective method and needs to be encouraged. Objective: The study was planned to know the perception of interns towards pharmacovigilance and to make them aware of the importance of ADR reporting. Materials and Methods: A cross sectional observational questionnaire based study conducted on 100 interns to gather information about the knowledge of Pharmacovigilance, attitude towards reporting and factors in practice which could act as a deterrent to the reporting of ADRs. Results: Out of the 100 interns, 90 responded. 50 % participants knew the purpose of PV. 67% agreed that it should be mandatory. 59% and 67% said that medical students and nurses have a role to play in PV. Half of the interns had seen an ADR, only 42% knew how and where to report. Very few (9%) were aware of what happens to the information submitted by them. Conclusion: There is a huge gap between knowledge of ADR reporting and pharmacovigilance and the practical reporting of ADRs. Our health care providers need to be well equipped to detect, manage, report ADRs. For this, educational intervention, regular training programmes are the need of the hour to create awareness and take care of the factors responsible for under reporting. Pharmacovigilance programme needs to be strengthened by increasing the rate of ADR reporting by active participation of health care providers.
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    Avoidable factors in head injury mortality.
    (1986-06-01) Sinha, R; Garg, P
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    Bilateral cystic pheochromocytoma: An incidental finding and a rare case entity.
    (2011-04) Gayathri, S; Baruah, B P; Kumar, S; Garg, P
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    Bone mineral content in normal and malnourished children.
    (1993-04-01) Chaturvedi, A; Garg, O P; Choudhary, B; Garg, P
    Bone mineral content (BMC) was determined at the distal radius in 70 children aged 2-14 years; Group I comprising 34 normal healthy children and Group II 36 malnourished children by the method of single photon absorptiometry. The mean value of BMC in Group I was 0.3 +/- 0.04 g/cm in 2-5 year, 0.52 +/- 0.08 g/cm in 6-10 year and 0.77 +/- 0.88 g/cm in 11-14 year age groups. No significant difference in the BMC was seen between boys and girls. An increase of BMC corresponded to growth spurts in 2-5 year and 11-14 year age groups. There was a significant reduction of BMC in Group II and in grade III malnutrition in 2-5 year and 11-14 year age groups as compared to Group I children. The study provides normal BMC data for Indian children and suggests that this can help to detect undemineralization of bones in malnourished children during the growth periods.
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    Cluster-analysis & patterns of dissemination of multidrug resistance among clinical strains of Vibrio cholerae in Calcutta, India.
    (2000-09-30) Ramamurthy, T; Rajendran, K; Garg, P; Shimada, T; Basu, A; Chowdhury, N R; Nandy, R K; Yamasaki, S; Bhattacharya, S K; Takeda, Y; Nair, G B
    BACKGROUND & OBJECTIVES: Antimicrobial resistance among Vibrio cholerae has been monitored for several years in Calcutta. To investigate the changing trends in multidrug resistance (MDR) among different serogroups of V. cholerae and to perform software assisted cluster analysis the current study was undertaken. METHODS: Strains isolated from patients with cholera and "cholera-like" diarrhoea admitted in the Infectious Diseases Hospital, Calcutta were analysed. Eight hundred and forty V. cholerae strains isolated from 1992 through 1997 were tested for susceptibility to 11 antibiotics. Cluster analysis was done using SPSS software. RESULTS: Most of the strains exhibited MDR with fluctuating trends as the resistance profile diverged each year. A total of 119 different resistance profiles exhibited by V. cholerae O1, O139 and non-O1, non-O139 serogroups were analysed by cluster combination method. During 1993 and 1994, 53 per cent of V. cholerae O139 and 82 per cent of V. cholerae O1 serogroups, respectively, exhibited maximal number of new resistance patterns. The frequency of new resistance patterns among V. cholerae non-O1, non-O139 was constantly high (33-47%) during 1995 to 1997. INTERPRETATION & CONCLUSIONS: With a few exceptions, preponderance of the resistance profiles was generally not confined to any serogroup. The cluster analysis depicted dissemination of some of the resistance patterns commonly found among V. cholerae non-O1, non-O139 belonging to different serogroups to the O139 serogroup in the succeeding years. In this study we have shown that the V. cholerae strains are resistant to several antibiotics with constant change in the MDR profiles. It is imperative to define the susceptibility pattern of the strains to determine the effective drug of choice for the treatment of cholera.
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    Commentary: Pythium insidiosum keratitis
    (All India Ophthalmological Society, 2019-01) Garg, P
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    Comparative evaluation of conservative management versus early surgical intervention in appendicular mass--a clinical study.
    (1997-06-01) Garg, P; Dass, B K; Bansal, A R; Chitkara, N
    The management of appendicular mass seems to be taking turn with the availability of better antibiotics, care and anaesthesia. Quite a few workers turned to the other extreme of traditional conservative approach and reported acceptable results with immediate intervention during phlegmonous stage. But practically, surgeons still continue to adopt the same old regime. To alleviate this fear and circumvent the disadvantages of immediate intervention a midpath regime called early appendicectomy has been clinically evaluated. With this new approach in the present study preventing misdiagnosis (15%), no chance of recurrence as also of missing in the follow-up and shorter overall hospital stay with economy are some strong reasons to adopt this regime.
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    A comparative study of preoperative and postoperative changes in corneal astigmatism after pterygium excision by different techniques
    (All India Ophthalmological Society, 2019-07) Garg, P; Sahai, A; Shamshad, MA; Tyagi, L; Singhal, Y; Gupta, S
    Purpose: To study the changes in corneal astigmatism before and after pterygium excision as well as with differences between various surgical techniques (bare sclera, conjunctival autograft, amniotic membrane graft). Methods: The study population included 71 patients with primary pterygium who underwent surgery. The surgical techniques used differed among the study population. All the patients were preoperatively assessed for visual acuity, anterior and posterior segments, autorefraction, and autokeratometry. After surgery, the patients were assessed for visual acuity, autorefraction, and autokeratometry on day 5, 1 month, and 3 months and the results were analyzed. Paired and unpaired t-tests were used to compare the variables. The probability level of 0.05 was considered as statistically significant. Results: The reduction in the mean preoperative astigmatism of 3.47 ± 1.74 Diopters (D) to 1.10 ± 0.78 D 3 months after surgery was statistically significant (P < 0.0001). Bare sclera, conjunctival autograft, and amniotic membrane graft techniques exhibited changes in astigmatism amounting to 1.85 ± 0.88 D, 2.55 ± 1.26 D, and 2.67 ± 1.44 D, respectively. Pterygium excision surgeries using amniotic membrane graft and conjunctival autograft techniques were more effective than pterygium excision surgery using bare sclera technique in reducing astigmatism. Conclusion: Pterygium excision results in significant reduction in astigmatism which leads to improvement in visual acuity. Amniotic membrane graft and conjunctival autograft are better surgical techniques than bare sclera as far as reducing astigmatism is concerned.
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    Correlation between chemical composition of biliary calculi and sera of stone formers.
    (2002-08-21) Pundir, C S; Rani, K; Garg, P; Chaudhary, R; Chandran, P; Kumari, M
    A quantitative chemical analysis of total cholesterol, bilirubin, calcium, inorganic phosphate and iron of three types of biliary calculi (cholesterol, pigment and mixed) of 40 gall stone former was carried out and correlated to with those of there sera. A moderately positive correlation for inorganic phosphate, Ca2+ and Fe2+ content of sera and calculi of cholesterol stone patient was found. A Good positive correlation for total cholesterol, a moderately positive correlation for bilirubin and iron but no correlation for inorganic phosphate and calcium content of sera and calculi of pigment stone patient was observed. A good moderately positive correlation for iron but no correlation for total cholesterol, bilirubin, inorganic phosphate and Ca2+ content of sera and calculi of stone patient was found.
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    Current practice in handling and reporting needle biopsies: A hospital-based survey
    (Indian Association of Pathologists and Microbiologists, 2018-06) Garg, P; Pathak, P; Goyal, R; Arora, VK; Singh, N
    Context: Core-needle biopsy (CNB) is a minimally invasive screening and diagnostic tool which provides intact tissue fragments for histopathological examination. Aims: This study was conducted to review the current practices of handling and reporting CNBs performed for core-needle biopsies from four organ systems which are frequently encountered in our institution. These include breast, prostate, soft tissues, and lymph nodes. Settings and Design: This was a retrospective study conducted at a tertiary care hospital. Materials and Methods: CNB reports of breast, prostate, soft tissue, and lymph nodes were accessed and categorized based on the site of biopsy, number, and average length of the cores. The CNB reports were categorized into diagnostic or nondiagnostic. In case of diagnosis of malignancy, reports were recorded as structured or nonstructured reports. Statistical Analysis Used: Fisher's exact test and Chi-square tests were applied to check the significance of the results obtained on comparing the number of cores and size of cores with the outcome of report. Results: Out of 16,300 surgical pathology specimens received, 400 were CNBs comprising breast (n = 211), prostate (n = 108), soft tissue (n = 50), and lymph node (n = 31). Majority of the CNBs had 2–5 cores and the size of the core was ≥0.5 cm, which accounted for most of the reports which were diagnostic. There was a lack of clinical and radiological detail in many of the cases. Out of the malignant cases diagnosed, structured reports were given in 30% of breast, 79.3% of prostate, 41.7% soft tissue, and 60% of lymph node needle biopsies. Conclusions: The audit helped to identify areas of improvement in CNB services.
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    Daughter diverticula from Meckel's diverticulum.
    (1997-04-01) Singla, S L; Garg, P; Singh, B
    Daughter diverticula arising from the body of Meckel's diverticulum are rare. We detected such an occurrence in a 35-year-old man at appendectomy. These are probably primary and not pulsion or traction diverticula, as they do not have a muscle wall.
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    Digital and clavicular bone metastasis from transitional cell carcinoma of urinary bladder: a case report.
    (1993-01-01) Marya, S K; Singh, S; Jaswal, T S; Garg, P; Gupta, A K
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    Discrete analysis of bile acid in serum and bile with 3 alpha-hydroxysteroid dehydrogenase and diaphorase immobilized onto alkylamine glass beads.
    (2006-04-08) Rani, Kirti; Garg, P; Pundir, C S
    3alpha-Hydroxysteroid dehydrogenase (3alpha-HSD) from Pseudomonas testosteronei and diaphorase (lipoyl dehydrogenase) from Clostridium spp were immobilized individually onto alkylamine glass beads through glutaraldehyde coupling. A cost-effective enzymic colorimetric method for determination of bile acid in the serum and bile was developed employing mixture of the immobilized enzymes. The method was based upon measurement of NADH generated from NAD+ during oxidation of bile acid by immobilized 3alpha-HSD with a color reagent consisting of nitrobluetetrazolium (NBT) chloride salt and immobilized diaphorase in 0.065 M sodium phosphate buffer (pH 7.0). The minimum detection limit of the method was 4.8 pmol/L in the serum and 19.5 micromol/L in bile. The per cent recovery of added bile acid in the serum and bile was 89.1 and 95.0, respectively. Within and between batch coefficients of variation (CV) for bile acid determination were <1.0% and <0.2% in the serum and <0.2% and <0.6% in bile, respectively. A good correlation for bile acid in the serum (r1= 0.95) and in bile (r2 = 0.93) was obtained by a standard chemical method (a commonly used method in India) and the present method. The mixture of immobilized 3alpha-HSD and diaphorase lost 30% of its initial activity after 4 months of regular use. The cost of bile acid determination for 100 the serum and bile samples by the present method was found to be lower than by a commercially available method (Sigma kit 450-A).