Browsing by Author "Dixit, A."

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    Drug repositioning: current scenario and future prospective for rewriting saga of drug development
    (Medip Academy, 2024-04) Dixit, A.; Mishra, A. K.; Singh, C. V.; Gupta, V. K.; Pandey, D.
    Drug development is a process that demands huge investment of resources and time with only 1 drug candidate successful in reaching market among 10,000 screened taking time duration of 10-15 years and millions of dollars. This high attrition rates discourage investors and researchers. The pharmaceutical industry is shifting its attention away from de novo drug research and towards discovering novel targets and indications for already-approved drugs. In order to accelerate the drug development process with reduced risk of failure and relatively lower costs, pharmaceutical companies have adopted drug repositioning as an alternative. Therefore, a good strategy for drug development would be drug repositioning or drug repurposing, which is to identify, investigate, and exploit new therapeutic uses of already-available, on-market drugs, as well as those that have been withdrawn due to toxicities or that remain on shelves in various stages of development. The outbreak of SARS-COV-19 shows that humanity is constantly vulnerable to epidemics and new microbial attacks and that there is no time to create disease-specific therapies. Consequently, it would seem advantageous to use what is already accessible. Novel therapeutic indications that have previously been approved by the market can reduce investment costs significantly in terms of money, resources, and most importantly, time, as long as they meet PKPD and toxicity standards. Sponsors and pharmaceutical corporations get enthusiastic about additional investments and initiatives related to drug development as a consequence. The upcoming therapeutic revolution, especially with the aid of artificial intelligence, is indicated by the successful applications of several already-available drugs against COVID-19 and the various phases of repurposed drugs against TB, colorectal cancer, Alzheimer抯 disease, cervical cancer, and Parkinsonism.
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    Renal involvement in COVID-19: a review report
    (Medip Academy, 2023-06) Pandey, P.; Palli, M.; Sawhney, A.; Dixit, A.
    COVID-19 is recent emerging pandemic caused by SARS-CoV-2 (severe acute respiratory syndrome- Coronavirus). It is seen mainly affecting lungs, but many recent studies have shown involvement of hematological, kidney, gastrointestinal and other systems. In kidneys it mainly affects the tubules and interstitial areas. The main pathology behind involvement of renal system in COVID-19 is due to presence of ACE 2 receptors in proximal tubules. These receptors are same like that found in lungs and they form binding sites for coronavirus and hence causing the disease. Therefore, patients presenting with raised serum urea and creatinine should be checked for potential renal damage caused by virus and their urine samples should also be tested for presence of coronavirus. Effective testing and prompt management will prevent this virus from being transmitted in community.
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    Renal involvement in COVID-19: a review report
    (Medip Academy, 2023-06) Pandey, P.; Palli, M.; Sawhney, A.; Dixit, A.
    COVID-19 is recent emerging pandemic caused by SARS-CoV-2 (severe acute respiratory syndrome- Coronavirus). It is seen mainly affecting lungs, but many recent studies have shown involvement of hematological, kidney, gastrointestinal and other systems. In kidneys it mainly affects the tubules and interstitial areas. The main pathology behind involvement of renal system in COVID-19 is due to presence of ACE 2 receptors in proximal tubules. These receptors are same like that found in lungs and they form binding sites for coronavirus and hence causing the disease. Therefore, patients presenting with raised serum urea and creatinine should be checked for potential renal damage caused by virus and their urine samples should also be tested for presence of coronavirus. Effective testing and prompt management will prevent this virus from being transmitted in community.
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    Two true knots in the umbilical cord: a rare case report
    (Medip Academy, 2025-06) Dixit, A.; Hood, M. M
    True knots of the umbilical cord are infrequent but significant complications in obstetrics, occurring in approximately 0.3% to 2% of pregnancies. Their formation is often associated with factors such as increased fetal mobility, excessive amniotic fluid, and maternal conditions like diabetes. These knots can lead to serious outcomes, including fetal distress and stillbirth, necessitating careful monitoring and management. We present the case of a 30-year-old woman Gravida 1 Para 1 Live birth 1 (G2P1L1) with a known case of type 2 diabetes mellitus who presented at 36 weeks and 6 days of gestation with mild labor pains. Upon evaluation, she exhibited persistent fetal tachycardia and non-progressing labor despite augmentation efforts. An emergency lower segment cesarean section (LSCS) was performed, revealing two true knots in a lengthy umbilical cord measuring approximately 70 cm, along with one loop wrapped around the neck. The timely intervention resulted in a favorable outcome for both mother and baby. This case highlights the importance of recognizing and managing true knots in pregnancies complicated by diabetes and other risk factors. As these noted are mostly obscured on ultrasound and diagnosis is made only post placental delivery, it underscores the need for vigilant prenatal monitoring and a low threshold for surgical intervention in cases of fetal distress.