Browsing by Author "Dayanandam"

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    Estimation of Serum Folate and Homocysteine Levels in Oral Submucous Fibrosis-A Prospective Study
    (Association of Medical Dental and Allied Sciences, 2017-06) Pushpanjali; Dayanandam; Satyasree, M.; Divya, Seelam; Pasupulati, Pravallika; Vasundhara
    Aim & Objective The aim of the study was to evaluate the levels of serum folate and homocysteine in clinical stages of Oral submucous fibrosis (OSF) patients. Methodology The study sample comprised of 40 clinically and histopathologically diagnosed OSF patients those who are not undergoing treatment and 10 healthy controls. OSF was categorised by clinical staging. Serum foliate and homocysteine levels estimation was done by reverse phase high performance liquid chromatography analysis unit and chemiluminescence immuno assay, respectively. Results were statistically analysed using one-way ANOVA [Analysis of variance]. Results Irrespective of age and gender, serum folate deficiency and high levels of homocysteine were noted in OSF patients when compared with healthy controls. Conclusion Serum hyper homocysteinemia and folate deficiency were noted with the progression of the disease. Folate supplements can be given to decrease the levels of homocysteine, to arrest the progression of the disease. However, further longitudinal studies are needed to establish an association between serum homocysteine and serum folate.
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    Levamisole Monotherapy in Treatment of Oral Lichen Planus-A Clinical Study
    (Association of Medical Dental and Allied Sciences, 2017-11) Pushpanjali; Dayanandam; Sultana, Juweria
    Background Oral lichen planus is a chronic inflammatory disease of oral mucosa which rarely undergoes spontaneous remission and has potential for malignant transformation. There are several different kinds of treatment that have been used to treat chronic oral lichen planus. Most commonly advised treatment is steroid therapy to treat oral lichen planus either in topical form or systemically. As steroid therapy has various underlying adverse effects other alternative drug has to be used in the treatment of oral lichen planus. Objective The aim of the study is to evaluate the efficacy of levamisole monotherapy in oral lichen planus. Methods Seven patients who had oral lichen planus were treated with levamisole 50 mg thrice daily for 3 consecutive days and not administered for the following 4 days. Result After 2 weeks of treatment, four patients reported with partial response, three patients had no response and no patients showed clearance of the lesion. Furthermore, after 2 months of treatment, five patients showed clearance of lesion, one patient showed partial response and one patient had no response to therapy. There were no significant side effects noted. Conclusion Levamisole therapy can be a substitute to steroid therapy in treating oral lichen planus in patients who can't take steroids.