Browsing by Author "Datta, Sutapa"

Now showing 1 - 2 of 2
  • Thumbnail Image
    Item
    Evidence for Wolbachia symbiosis in microfi lariae of Wuchereria bancrofti from West Bengal, India.
    (2010-03) Gayen, Prajna; Maitra, Sudipta; Datta, Sutapa; Babu, Santi P Sinha
    Wolbachia are symbiotic endobacteria that infect the majority of fi larial nematodes, including Wuchereria bancrofti, Brugia malayi and Onchocerca volvulus. Recent studies have suggested that Wolbachia are necessary for the reproduction and survival of fi larial nematodes and have highlighted the use of antibiotic therapy such as tetracycline/ doxycycline as a novel method of treatment for infections caused by these organisms. Before such therapy is conceived and implemented on a large scale, it is necessary to assess the prevalence of the endosymbiont in W. bancrofti from different geographical locations. We present data from molecular and electron microscopic studies to provide evidence for Wolbachia symbiosis in W. bancrofti microfi lariae collected from two districts (Bankura and Birbhum) of West Bengal, India.
  • No Thumbnail Available
    Item
    A review of gut microbiota as a therapeutic approach for Parkinson’s disease
    (Wolters Kluwer – Medknow, 2024-12) Ghosh, Debosree; Ghosh, Suvendu; Sharma, Madhurima; Datta, Sutapa
    Parkinson’s disease (PD) is a neurodegenerative disorder that affects the brain–gut axis, manifesting through both motor dysfunction and nonmotor symptoms. While several factors contribute to PD, the precise cause remains unknown. Research studies suggest that an altered gut microbiota (GM) plays a key role in PD pathophysiology. Gut dysbiosis compromises the integrity of the intestinal epithelium, increasing gastrointestinal permeability. This, in turn, activates the innate immune system, leading to systemic inflammation, whereas the adaptive immune system responds to bacterial proteins through cross-reactivity with human antigens. The altered GM promotes the accumulation of alpha-synuclein fibrils in the intestinal neural plexus, which are then transported to the central nervous system, driving the core pathological process of PD. This review focuses on the connection between gut dysbiosis, PD pathology, and current microbial-based therapeutic interventions. Furthermore, research into innovative approaches to modulate the GM and reinforce gut epithelial integrity is crucial to halting or slowing PD progression.