Browsing by Author "Datta, S."

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    Effect of aqueous extract of Ardisia colorata Roxb. leaves on blood sugar in Albino rats
    (Medip Academy, 2024-06) Ningthoujam, G.; Datta, S.; Zosangpuii, C.; Meena, N.; Medhabati, M.
    Background: Diabetes is a group of common metabolic disorders that share the characteristic features of hyperglycemia. Ardisia colorata Roxb. leaf extract (AEAC) is reported to be used for the treatment of diabetes. So, the present study is undertaken to evaluate the effect of Ardisia colorata Roxb. leaves on blood sugar by using different hyperglycemic models in Albino rats. Methods: In both the glucose induced hyperglycemia model and streptozotocin induced hyperglycemia model, animals were divided into 4 groups of 6 animals each. 2% gum acacia were taken as control (group 1) and glimepiride 0.2 mg/kg were taken as standard (group 2). Hyperglycemic activity was checked at two different doses i.e., 200 mg/kg (test 1) and 400 mg/kg (test 2) of AEAC (given at group 3 and group 4 respectively) by assessing the decreased in blood sugar level using glucometer by following methods of these two models. The results were analyzed using one-way analysis of variance (ANOVA) followed by Bonferroni test. P value <0.05 was considered significant. Results: Test 2 showed significant reduction in blood sugar level when compared to control after 1 hour and 2 hours of drug administration in both the models whereas test 1 showed significant reduction only in glucose induced hyperglycemia model. There was significant difference when test 2 was compared to test 1 after 1 hour and 2 hours in both the models. Conclusions: The present studies showed that AEAC leaves produced significant reduction in blood sugar level. It might be suggested that flavonoids, alkaloids, tannins and terpenoids were responsible for the hypoglycemic activity of AEAC leaves.
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    Habit nail tic disorder: onychotillomania involving thumbs and toes responding to fluoxetine
    (Medip Academy, 2024-05) Bose, A.; Maji, T.; Datta, S.; Mallik, N.; Bandyopadhyay, G. K.
    Habit nail tic disorder is a type of nail dystrophy caused by repetitive trauma to the nail matrix. It is a body-focused repetitive behavior that is commonly reported among adults and may or may not be associated with obsessive-compulsive behavior. In this report, we present a case of a 12-year-old adolescent girl who had a central furrow with longitudinal ridges running parallel from the proximal to the distal end of both her thumbnails and toenails, giving them a "washboard" appearance and diagnosed as habit nail tic disorder, and treatment involved fluoxetine 20 mg and the application of permeable adhesive tape to protect the nails from external trauma. There was a positive response observed two months after the beginning of the treatment and the nail matrix resolved spontaneously.
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    Self inflicted injury in a case of delusional parasitosis
    (Medip Academy, 2024-07) Ghosh, A.; Bhattacharyya, D.; Datta, S.; Roy, S.; Bandyopadhyay, G. K.; Kundu, M.; Sarkar, A
    Delusional parasitosis also known as Ekbom抯 syndrome, is a fixed, firm, false belief about a parasitic infestation of skin despite absence of evidence. Non-suicidal self injury (NSSI) is the deliberate and direct change leading to destruction of healthy body tissues e.g. skin cutting, scratching, burning, hitting of oneself and even enucleation of eye and amputation of body parts. We present a case of a 35-year-old male patient with delusional parasitosis for the past 3 months, referred from dermatology, who resorted to cutting himself on his arm and abdomen. He was treated successfully with anti-psychotics and had no further intention of self-harm.