Browsing by Author "Chowdhury, Ayub Ali"

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    Association of Serum NT-Pro-BNP Level with Echocardiography Results Among CKD Patients: A Cross Section Study at NIKDU in Dhaka Bangladesh
    (Ibn Sina Academy of Medieval Medicine & Sciences, 2023-08) Ripa, Rokhsana Alam; Islam, Shafiqul; Haque, Mohammad Farhadul; Kibria, Golam; Faysal, Amanur Rasul Md.; Chowdhury, Ayub Ali
    Background: Mortality of CKD patients remains high because of high prevalence of cardiovascular diseases among them. Identifying serum biomarkers that are useful in profiling cardiovascular risk is an important goal in the treatment of CKD patients. The aim of the present study is to assess the relationship between serum NT-Pro-BNP level as a biomarker and Echocardiography findings among CKD patients without symptoms or history of cardiac diseases. Method: This cross-sectional study among 149 CKD patients was conducted from January to December 2020 at National Institute of Kidney Diseases and Urology (NIKDU), Dhaka. Serum NT-Pro-BNP levels were measured for each study subject. All patients had a comprehensive M-mode, two- dimensional, and doppler echocardiogram. Association between serum NT-Pro-BNP levels and echocardiogram findings were assessed. Result: Mean age of study population was 50.0 ± 12.4 years, male predominant (53%). Mean serum NT-Pro-BNP level was lowest (335.7 ± 213.3 pg/ml) for patients with CKD stage 1, which significantly increased with the progression of CKD stages, reaching highest (15644.6 ± 2197.5 pg/ml) for patients with CKD stage 5. There was statistically significant (P < 0.05) reduction in LVEF with increasing severity of CKD and significant negative correlation (r = - 0.316, p < 0.001) between serum NT-Pro-BNP level and LVEF. Mean IVSTd and PWTd, both significantly (p < 0.05) increased with the progression of CKD stages. Significant positive correlation was seen between serum NT-Pro-BNP and IVSTd (r = 0.361, p < 0.001) and between serum NT-Pro-BNP and PWTd (r = 0.448, p < 0.001). Conclusion: NT-Pro-BNP has the potential to be used routinely as a screening tool for patients with CKD for cardiac structural and functional abnormalities.