Browsing by Author "Chandra, T"
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Item Antiallergic activity of alkyl substituted pyrazolo[3, 4-d]pyrimidine (compound 88-765).(1995-01-01) Gupta, P P; Srimal, R C; Avasthi, K; Garg, N; Chandra, T; Bhakuni, D SCompound 88-765 (4-amino-6-methylthio-1-(2', 2'-diethoxyethyl)-1 H-pyrazolo[3, 4-d]pyrimidine) has shown potent antiallergic activity in experimental models. The compound inhibited the passive cutaneous anaphylaxis (PCA) reaction in rats in dose-dependent manner (5-100 mg/kg, po) by 47 to 87%. In mice it inhibited PCA by 78% at 50 mg/kg, po. It also inhibited mast cell degranulation of normal and passively sensitised rats induced by compound 48/80 and egg albumin, respectively. These effects of Compound 88-765 were comparable with that of disodium cromoglycate (DSCG). The results suggest that compound 88-765 possesses potent antiallergic activity.Item "Assessment of cellular immunity in patients with carcinoma of lung".(1981-04-01) Shanker, R; Agarwal, B M; Singh, S N; Rajvanshi, V S; Chandra, TItem Diagnostic relevance of silver stained nucleolar organizer region (AgNORs) in benign and malignant breast lesions.(1995-10-01) Agarwal, P K; Mehrotra, A; Chandra, TThe present study is planned to assess the diagnostic relevance of silver stained nucleolar organizer regions (NORs) in discriminating benign from malignant lesions of the breast and to ascertain the interobserver variability in the enumeration of AgNOR counts. Forty four specimens of benign and malignant breast tissues were studied and mean number of silver stained nucleolar organizer regions (MNORA) have been counted in paraffin sections. Malignant lesions have a higher number of MNORA than benign lesions. These results also showed correlation between the AgNOR counts and size of the tumor, axillary lymph node status and age of the patient. Our results also indicate a close agreement between the two observers with limits of agreement. However, AgNOR counts are of little diagnostic importance since a broad zone of overlap exists between benign and malignant breast diseases despite significant higher mean counts in malignant lesions. AgNOR sequence could perhaps be of use to differentiate those two histological indistinguishable lesions. The tumor size and axillary lymph node involvement suggested to its prognostic significance also. Interobserver agreement further suggests the utility of AgNOR counts as diagnostic or prognostic discriminants in breast malignancies.Item Evaluation of the role of aortorenal angiography in renal diseases.(1972-08-16) Razdan, J L; Jain, S P; Tripathi, S; Chandra, TItem Immunohistochemical localization of transferrin in human breast cancer tissue.(2000-10-10) Agarwal, P K; Mehrotra, A; Chandra, T; Singh, KThe present study was planned to detect the iron binding protein, transferrin (TR) in paraffin sections of the human breast tumors. The distribution of transferrin has been studied in 153 cases (63 benign lesions and 90 malignant tumors). The extent of staining reaction was determined by semiquantitative grading (weak, moderate and consistent). Positivity rate for transferrin was higher (92.2%) in malignant tumors as compared to benign breast lesions (28.5%) with significant p value (p = 0.0001) for both the groups. The intensity was variable in both the groups, being more intense in the malignant tumors. Tumors with higher grade of malignancy presented consistent positive staining along with the lymph nodes involved. The extent of immunoreactivity revealed a significant positive correlation with axillary lymph node status. However, no significant correlation was found with the age of the patients. Thus the study of transferrin in breast tumors besides being of prognostic significance helps in the further management of malignant lesions of the breast.Item Immunohistochemical localization of transferrin in human breast cancer tissue.(2001-04-09) Agarwal, P K; Mehrotra, A; Chandra, T; Singh, KThe present study was planned to detect the iron binding protein, transferrin (TR) in paraffin sections of the human breast tumors. The distribution of transferrin has been studied in 153 cases (63 benign lesions and 90 malignant tumors). The extent of staining reaction was determined by semiquantitative grading (weak, moderate and consistent). Positivity rate for transferrin was higher (92.2%) in malignant tumors as compared to benign breast lesions (28.5%) with significant p value (P = .0001) for both the groups. The intensity was variable in both the groups, being more intense in the malignant tumors. Tumors with higher grade of malignancy presented consistent positive staining along with the lymph nodes involved. The extent of immunoreactivity revealed a significant positive correlation with axillary lymph node status. However, no significant correlation was found with the age of the patients. Thus the study of transferrin in breast tumors besides being of prognostic significance helps in the further management of malignant lesions of the breast.Item Knowledge, attitudes, and practices towards COVID-19 among blood donors during the COVID-19 outbreak(MRI Publication Pvt. Ltd., 2022-09) Singh, A; Maurya, PK; Solanki, A; Chandra, T; Sachan, B.Background: Assessments of the blood donors’ knowledge, attitudes, practices, and perceptions of this infection are essential for controlling the spread of COVID-19. Aim and objectives: This study aimed to evaluate the KAP among blood donors towards COVID 19 pandemic and how to increase the number of blood donations during pandemic. Materials and Methods: This study was conducted among 630 blood donors at the Department of Transfusion Medicine, at a tertiary care center in North India. It was an observational study. Statistical analysis: The data were analyzed using Kruskal-Wallis and MannWhitney test. To correlate variables Chi-square test was used. Results: The knowledge score of demographic variables marital status, education & occupation showed a significant association, while its association with age, gender, and religion was insignificant. The entire demographic variables under study showed a significant association with Attitude questionnaire 1. According to univariate analysis, the variables Intercept, Unemployed and Physical Labour showed significant impact on knowledge level with the corresponding effect size 0.10 and 0.022. Conclusions: This study reveals that blood donors have good knowledge with positive attitudes and practices. By improving the knowledge with the help of health education platforms, the number of blood donations will also increase.Item Primary intrapulmonary teratoma presenting as pyothorax.(1999-01-20) Tandon, S; Kant, S; Singh, A K; Sinha, K N; Chandra, T; Agarwal, P KA female patient presented with empyema thoracis and was planned for decortication. Peroperatively a cystic mass was found in the left lower lobe which was resected and diagnosed as a case of teratoma of lung on histopathological examination. This unusual case of primary intrapulmonary teratoma is being reported here.Item Statistical significance of AgNOR counts in FNAC smears and corresponding histopathological sections.(1998-02-01) Mehrotra, A; Chandra, TThe object of the present study was to determine the statistical significance of AgNOR counts in fine needle aspiration cytology (FNAC) smears and corresponding paraffin sections by using an one step silver colloidal staining method. Ninety five cases (31 benign and 64 malignant) were taken and a correlation between smears and sections was studied by two different observers. The total number of mean (SD) AgNOR counts was significantly higher in FNAC smears in benign (3.081 +/- .753) and malignant (7.101 +/- 1.544) neoplasms in comparison to paraffin sections in the same group of cases. FNAC smears had a cut off point 4 with proliferation index 1% in benign tumors and 97.5% in malignant tumors. Sections had an overlapping of AgNOR counts (5-7) with proliferation index 3.8 and 82% for benign and malignant groups respectively. The difference in the coefficient of variations was 3% in benign group and 2% in malignant group in FNAC smears while sections had 6 and 8% difference in the coefficient of variations. Smears present a superior staining and accurate number of AgNOR dots in nucleus as compared to paraffin sections. Therefore the results suggest that AgNOR technique can be successfully used in FNAC smears in comparison to paraffin sections to differentiate benign and malignant tumors in routine laboratory diagnosis.Item Suggestions to medical profession to fight against CPA.(1993-11-01) Chandra, T