Browsing by Author "Chakraborty, D"

Now showing 1 - 14 of 14
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    46 3q+ karyotype presenting as syndrome with obesity and hypogonadism.
    (2001-04-05) Raman, P G; Shende, A; Chakraborty, D; Akolekar, S S
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    Aborted bridge coloboma with scleral fistula
    (All India Ophthalmological Society, 2020-03) Chakraborty, D; Das, D
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    Antimicrobial activity of leaf extract of Basilicum polystachyon (L) Moench.
    (2007-08-20) Chakraborty, D; Mandal, S M; Chakraborty, J; Bhattacharyaa, P K; Bandyopadhyay, A; Mitra, A; Gupta, K
    Phenolic extract of leaves of Basilicum polystachyon (L) Moench was tested for in vitro antimicrobial activity against five bacteria (Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Bacillus subtilis, Micrococcus leuteus) and three fungi (Fusarium oxysporum, Aspergillus niger, Helminthosporium oryzae). Efficacy of organic solvents, methanol and ethanol, as agents for extraction was compared with acidic water (2M; HCl). High-pressure liquid chromatographic (HPLC) data showed that acidic extraction (2M; HCl) resulted in higher yield of caffeic acid (0.437 mg g(-1)) and rosmarinic acid (0.919 mg g(-1)). Acidic extract showed high activity against Gram (+) ve bacteria, but was less active against Gram (-) ve bacteria. Amongst the tested fungi, maximum activity was exhibited against Aspergillus niger. This is the first report on the phenolic constituents and bioactivity of B. polystachyon.
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    A case of subacute onset dementia due to sertraline.
    (2003-03-04) Chakraborty, D; Agarwal, C S; Rohatagi, R
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    Characterisation and identification of broad spectrum antibiotic producing Streptomyces hygroscopicus D 1.5.
    (1995-02-01) Chakraborty, D; Mondal, B; Pal, S C; Sen, S K
    A streptomycete strain D1.5 capable of producing broad spectrum antiobiotic was isolated from soil. The morphological, cultural, physiological and biochemical characters were studied, compared to known species and identified as Streptmoyces hygroscopicus. Antibiotic activity of the strain was tested against both Gram positive and negative bacteria as well as fungi. It exhibited complete resistance to beta-lactum antibiotics.
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    Colicinogenicity and enteropathogenicity of Escherichia coli associated with gastroenteritis in man.
    (1998-12-16) Chakraborty, D; Nag, N C
    Sixty strains of Escherichia coli, were isolated and identified from 94 samples of infantile diarrhoea and traveller's diarrhoea. Eleven strains were found to be colicinogenic and colicin 'H' was found to be predominant in conjunction with other colicins. Five strains were enteropathogenic of which 055 and one untypable strain were highly enteropathogenic. A positive correlation could be established between haemolytic character, dulcitol fermentation and the virulence of the strain involved.
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    A comparative study of timolol plus either brimonidine (0.2%) or dorzolamide (2%) or latanoprost (0.005%) dual therapy in suboptimal responders to timolol (0.5%) monotherapy among patients of open-angle glaucoma, ocular hypertension and normal-tension glaucoma
    (Mrs Dipika Charan of MedScience (India) Publications, 2022-03) Chakraborty, D; Bagchi, C; Tripathi, SK.
    Background: Studies comparing the efficacy and tolerability of the three fixed combinations of timolol with its monotherapy are not readily available. In this background, the current prospective observational study was planned. Aim and Objective: To evaluate and compare the intraocular pressure (IOP) reduction, change in visual field, and cup-disc ratio in glaucoma patients receiving timolol monotherapy vis-a-vis timolol based dual therapies among timolol sub-optimal responders. Materials and Methods: After obtaining written informed consent and fulfilling the inclusion-exclusion criteria, fifty consecutive newly diagnosed cases of glaucoma or ocular hypertension with risk factors were recruited in the study. They received timolol eye drop up to 4th week. Participants not responding to timolol monotherapy optimally received either timolol plus brimonidine or timolol plus dorzolamide or timolol plus latanoprost for another 12 weeks. Participants responding optimally (at least 30% reduction of baseline) were continued with timolol monotherapy. Besides IOP changes, effects on visual field, visual acuity, cup disc ratio, safety, tolerability, and rate of persistency to therapy were studied. Results: Fifteen participants (30%) achieved target IOP reduction at 4 weeks of timolol monotherapy. All four treatment groups achieved significant IOP reduction (P < 0.001) from baseline to 16th week. Participants receiving timolol followed by timolol plus latanoprost had shown the highest IOP reduction at 16th week both from baseline and 4th week value (ANOVA test, P = 0.027, P = 0.000 respectively). No change in visual field or visual acuity or cup disc ratio was noticed. Adverse drug reactions observed were mild and mostly self limiting. Conclusion: Timolol and latanoprost combination might be a better choice in sub-optimal responders to timolol whereas it is wise to continue timolol monotherapy in optimally responders.
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    Effect of cimetidine on adenohypophysis of male albino mice under certain experimental condition.
    (1993-07-01) Chakraborty, D
    Effect of 75 mg/kg of body weight of cimetidine administered intraperitoneally daily for 14 days to two groups of experimental animals (one of the experimental group was having intact testis and another group was bilaterally orchidectomized) was observed on cell population & cell volume of gonadotrophs and lactotrophs in pituitary gland, as it has not been studied earlier. In the experimental group of intact testis, there was significant reduction in the cell population of FSH cells in the cephalomedian area (P < 0.001) and in the lateral lobe (P < 0.01); the volume of both FSH and LH cells was also significantly reduced. In group 4 and group 5 there was significant increase in the population of lactotrophs and also in the volume of LH cells, FSH cells & lactotrophs. The change in the gonadotrophs in group 2 was due to increased production of testosterone from hypertrophied Leydig cells of testis rather then it's direct effect on adenohypophysis; in group 4 and group 5 the changes were due to lack of testosterone as in those cases bilaterally orchidectomy already done.
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    Effect of hormones on the development of various brush border enzymes across crypt-villus axis in rat intestine.
    (1988-08-01) Gupta, R; Babbar, H S; Jaswal, V M; Chakraborty, D; Mahmood, A
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    Effect of phenobarbitone on pituitary gland of male albino mice.
    (1993-04-01) Chakraborty, D; Karanth, S
    The effects of phenobarbitone on gonadotrophs and lactotrophs of pituitary gland were studied in male albino mice which were administered phenobarbitone 50 mg/kg body weight intraperitoneally (ip) daily for 14 days. A group of control mice were administered saline ip. In the experimental group, there was significant reduction in the average cell population of FSH cells in the cephalomedian area (P < 0.001) and in the lateral lobe (P < 0.01). The average volume of both FSH and LH cells was also significantly reduced (P < 0.001). The changes in the gonadotrophs of the experimental group could be attributed to the negative feedback action of testosterone which is being secreted from hypertrophied Leydig cells of testis.
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    The Impact of the COVID-19 Pandemic on Health-Care Delivery System for Other Diseases and Antimicrobial Resistance Threat in India
    (Wolters Kluwer – Medknow, 2022-06) Chakraborty, D; Majumdar, A; Debnath, F; Naskar, S; Dutta, S.
    India’s health‑care delivery is challenged with different inequalities and the dual burden of communicable and noncommunicable diseases. Lockdown posed negative effects on the growth and economy of the country; simultaneously, some positive effects, like increased health consciousness and adoption of hygienic practices, were also there. Health‑care delivery system faced tremendous challenges in diagnostics, therapeutics, infrastructure for inpatient care, and protection of health‑care manpower. During this period, people chose to self medicate which in turn increased the threat of emergence of antimicrobial resistance. Due to shifting priority to COVID from other diseases, resources were shifted to COVID, affecting the management of other acute and chronic diseases. The launching of COVID‑19 vaccination campaign showed some hope. However, despite the vaccination drive, strengthening infrastructure, and surveillance system, the devastating second wave could not be avoided due to the conglomeration of the crowd for pilgrimage, election campaign, and tourism in an unrestricted manner. It may be concluded that the fourth wave may be short lasting due to increased herd immunity.
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    A Rare Case Report of Leprous Macrocheilia in Borderline Tuberculoid Leprosy with Type 1 Reaction
    (Hind Kusht Nivaran Sangh (Indian Leprosy Association), 2023-06) Gupta, I; Chakraborty, D; Dayal, S; Khichi, D
    It is well known that Mycobacterium leprae tends to target the cooler parts of the body and can involve the oral cavity. Despite this, macrocheilia - a condition where the lips become enlarged - caused by leprosy is rarely documented. There are few reported cases of leprous macrocheilia in India. We present a unique case of an elderly woman with borderline tuberculoid leprosy in type I reaction who developed leprous macrocheilia.
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    Role of anabolic steroid in clean surgical wounds.
    (1986-04-01) Nandi, N C; Mukherjee, S K; Chakraborty, D; Chandra, A K
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    Ultra-widefield image of a toxocara granuloma with an adjacent retinal break and retinal detachment
    (All India Ophthalmological Society, 2019-11) Chakraborty, D; Boral, S; Mukherjee, A; Majumdar, S