Browsing by Author "Chakrabarty, A N"
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Item Antibacterial activity of local anaesthetics procaine & lignocaine.(1988-05-01) Dastidar, S G; Das, S; Mookerjee, M; Chattopadhyay, D; Ray, S; Chakrabarty, A NItem Antibacterial activity of the antiinflammatory agent diclofenac sodium.(1998-01-16) Annadurai, S; Basu, S; Ray, S; Dastidar, S G; Chakrabarty, A NAntimicrobial property of ten antiinflammatory drugs was tested with eleven sensitive bacteria belonging to both Gram positive and Gram negative types. Since most of the bacteria were moderate to highly sensitive to diclofenac (Dc), this compound was tested in vitro against 397 bacteria, most of which were inhibited by Dc at 50-100 micrograms/ml level. When tested in vivo, Dc at 1.5 and 3.0 micrograms/g body weight of a Swiss strain of white mice, could significantly protect the animals challenged with 50 MLD of Salmonella typhimurium NCTC 74. According to chi 2 test the in vivo data were highly significant (P < 0.001).Item Antibacterial property of methyl-DOPA & development of antibiotic cross-resistances in m-DOPA mutants.(1986-08-01) Dastidar, S G; Mondal, U; Niyogi, S; Chakrabarty, A NItem Antibacterial property of promazine hydrochloride.(1977-04-01) Dash, S K; Dastidar, S G; Chakrabarty, A NItem Antibiotic cross-resistence patterns of lysozyme resistant mutant staphylococci.(1981-02-01) Chakraborty, P; Dastidar, S G; Chakrabarty, A NItem Antibiotic strategy of urinary tract infections.(1978-06-01) Chakrabarty, A NItem Antimetabolic activity of some commonly used drugs.(1987-12-01) Hossain, M; Dastidar, S G; Chakrabarty, A NItem Antimicrobial potentiality of a new beta-lactum antibiotic fosfomycin.(1997-03-01) Dastidar, S G; Mazumdar, A; Mookerjee, M; Chakrabarty, A NAntimicrobial action of penicillin and some of its derivatives including fosfomycin was studied with respect to 225 strains of Gram-positive and Gram negative bacteria. Fosfomycin was found to possess somewhat less activity against Staphylococcus aureus compared with other penicillins; however, it showed powerful activity towards Escherichia coli, Klebsiella spp. and Proteus mirabilis.Item Bacteriological findings of dysenteric disorders in Calcutta.(1967-11-01) Sharma, A K; Majumdar, S K; Chakrabarty, A NItem Biological and biochemical characteristics of vibriocins.(1984-01-01) Dastidar, S G; Chakrabarty, A; Datta, S; Rao, C V; Chakrabarty, A NItem Correlation between lysozyme and bacitracin resistances in bacteria.(1985-05-01) Basu, S; Dastidar, S G; Ganguly, M; Chakrabarty, A NItem Correlation between occurrence of leprosy and fossil fuels: role of fossil fuel bacteria in the origin and global epidemiology of leprosy.(1989-06-01) Chakrabarty, A N; Dastidar, S GOn the basis of correlative data on the global distribution of leprosy, its bacteria metabolizing fossil fuels (FF), and the FF themselves, the origin of leprosy in the world as a whole, and in the leprosy-free countries, in particular, as indigenous cases, appeared to be primarily due to a soil-to-man, and secondarily due to a man-to-man infection. These findings helped to elucidate similar problems of animal leprosies and nocardial diseases.Item Crystal violet ring response as a marker for in vitro detection of pathogenic Vibrio parahaemolyticus & Shigella spp.(1987-05-01) Chakrabarti, T; Chakrabarty, A N; Dastidar, S GItem Cultivation in vitro of acid-fast nocardioform chemoautotrophic bacteria from mouse foot-pads infected with human strains of leprosy bacillus.(1990-04-01) Chakrabarty, A N; Dastidar, S G; Das, S; Chandra, A KFour acid-fast nocardioform bacteria could be isolated and cultivated as pure cultures in vitro from mouse foot-pads (MFP), which were infected with serially passaged strains of human leprosy bacillus; the liquid mineral medium, such as paraffin urea minimal (PUM), paraffin gelatin minimal (PGM), gelatin minimal (GM), and GM agar (GMA) slants containing only simple sources of C and N were used, just like the human and the armadillo isolates of these organisms reported earlier. Morphologically, metabolically and enzymologically, these were closely related to the previous ones and were also chemoautotrophic in nature. Serologically there appears to be a heterogenicity in these isolates, i.e., some of them showing higher affinity to nocardioforms while others showing significant binding to several mycobacteria. Normal (uninfected) mouse foot-pad harvests were not found to harbour such organisms.Item Cultivation of a nocardioform acid-fast chemoautotrophic bacterium from armadillo tissues infected with Mycobacterium leprae.(1990-03-01) Dastidar, S G; Chakrabarty, A NA nocardioform bacterium was isolated from the spleen tissue of an armadillo infected with M. leprae and easily propagated in pure culture in mineral salt medium supplemented with only simple C and N sources (e.g., liquid paraffin, tetradecane, ammonium salts, urea, asparagine, gelatin, xanthin, hypoxanthin etc.). Complex organic substances, e.g., tyrosin, casein, peptone, meat extract, egg proteins, serum, blood, yeast extract as well as medium 199, did not support the growth of this organism. Microscopically, the organism consisted of acid-fast, long, slender rods which originated from long, fragmented hyphae, or sporulating mycelial tufts; it was acid-fast (at less than 4.0% H2SO4) which was pyridine-susceptible. It produced DOPA-oxidase and Catalase and was lysozyme resistant; this grew best under reduced O2 tension, at pH 7.0 to 8.0 and 28 degrees C. Serologically, it appeared to be only weakly related to the prototype human multibacillary leprosy-derived (reference) nocardioform strain, Nocardia brasiliensis and N. caviae, but was variably related to several mycobacteria strains.Item Decarboxylase reactions of vibrios.(1969-10-01) Sanyal, A; Dastidar, S G; Chakrabarty, A NItem Deterioration kinetics of antibodies in different antibiotic media.(1979-04-01) Biswas, A N; Dastidar, S G; Chakrabarty, A NItem 'DNA' as contaminants in antibiotics and its capacity to transform bacteria to drug resistance.(1990-01-01) Chakrabarty, A N; Dastidar, S G; Ganguli, M; Chattopadhyay, DDNA/and deoxyribose sugars were detected in streptomycin (Sm), kanamycin, polymyxin, penicillin G, ampicillin, methicillin, cloxacillin and mitomycin C in small amounts/traces. Stained DNA could be feebly visualized directly in Sm run in agarose gel, which improved after its separation and concentration. These DNA materials were DNase sensitive, RNase and pronase resistant, and appeared to consist of fragments, c. less than or equal to 6 Mdal; this could repeatedly transform to SmR several recipient enterobacteria and vibrios; E. coli C600 and S. typhi 57, after such transformation revealed similar plasmid DNA bands that were absent in their wild-types. G + C mole% of plasmid and chromosomal DNA of recipient (57) along with that of Streptomyces griseus reference strain, suggested an extraneous origin for the plasmid DNA.Item Drug interaction of promethazine & other non-conventional antimicrobial chemotherapeutic agents.(1989-07-01) Chakrabarty, A N; Acharya, D P; Neogi, D; Dastidar, S GThe antihistamine compound promethazine (Pz) showed significant antibacterial action when tested against 124 strains of aerobic and 13 strains of anaerobic bacteria belonging to both Gram positive and Gram negative genera. The range of MIC (micrograms/ml) of Pz varied between 50 and 200 micrograms/ml among most of the test organisms. Six Pz-sensitive strains were found to be simultaneously sensitive to similar non-conventional antimicrobics, e.g., methdilazine, bromodiphenhydramine, diphenhydramine, methyl-DOPA, promazine and the antibiotic augmentin. A high degree of synergism was observed in vitro when Pz was used in combination with methdilazine and bromodiphenhydramine.Item Editorial: Passive prophylaxis in tetanus.(1975-03-01) Chakrabarty, A N