Browsing by Author "Chakrabarti, SS"

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    Awareness of Geriatric Services among North Indian Graduate Medical Students – Insights for Planning Training in Geriatric Medicine
    (Wolters Kluwer – Medknow, 2025-06) Fatima, Z; Lahari, TSS; Pandey, A; Chakrabarti, SS; Kaur, U.
    Background: The older population is rapidly increasing in India. We aimed to understand the perception of graduate medical students toward geriatric medicine services, which might aid in future geriatric curriculum planning. Materials and Methods: The current study is a cross-sectional questionnaire-based survey that was conducted in a major tertiary university hospital in North India. Final-year graduate medical students and medical interns were included in this survey after obtaining written informed consent. Results: One hundred and fifty?two medicalstudents(91 final year and 61 interns) were interviewed. The majority (90.8%) were aware of the existence of geriatric health services (GHS). One hundred and forty-nine (98%) agreed to the need for a separate GHS. The important reasons, as per the students, were physiological differences (40%), multimorbidity (22.4%), and atypical clinical presentations in older persons (20.4%). The majority (70.8%) of students had poor knowledge of the role of a pharmacologist in GHS. One hundred and thirty-seven (90.1%) students had poor awareness of medical institutions providing geriatric residency programs. Nearly two-thirds of the students were willing to join such programs, but it was the least preferred clinical choice. Fewer job prospects (46.1%) and lack of public awareness (19.2%) were the most common reasons for unwillingness. Conclusions: Revisions are needed in the teaching curriculum of Indian medical students with an emphasis on a multifaceted approach to older persons’ health care. The career prospects of students pursuing the subject should be strengthened.
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    New genetic players in late-onset Alzheimer's disease: Findings of genome-wide association studies
    (Indian Council of Medical Research, 2018-08) Misra, A; Chakrabarti, SS; Gambhir, IS
    Late-onset Alzheimer's disease (LOAD) or sporadic AD is the most common form of AD. The precise pathogenetic changes that trigger the development of AD remain largely unknown. Large-scale genome-wide association studies (GWASs) have identified single-nucleotide polymorphisms in multiple genes which are associated with AD; most notably, these are ABCA7, bridging integrator 1 (B1N1), triggering receptor expressed on myeloid cells 2 (TREM2), CD33, clusterin (CLU), complement receptor 1 (CRI), ephrin type-A receptor 1 (EPHA1), membrane-spanning 4-domains, subfamily A (MS4A) and phosphatidylinositol binding clathrin assembly protein (PICALM) genes. The proteins coded by the candidate genes participate in a variety of cellular processes such as oxidative balance, protein metabolism, cholesterol metabolism and synaptic function. This review summarizes the major gene loci affecting LOAD identified by large GWASs. Tentative mechanisms have also been elaborated in various studies by which the proteins coded by these genes may exert a role in AD pathogenesis have also been elaborated. The review suggests that these may together affect LOAD pathogenesis in a complementary fashion.