Browsing by Author "Chakrabarti, S."

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    Is there any correlation between tumor infiltrating lymphocytes and expression of EGFR in squamous cell carcinoma of head and neck? A retrospective observational study
    (Wolters Kluwer - Medknow, 2022-06) Dasgupta, S; Biswas, N; Deb, AR; Chakrabarti, S.
    Background: The dismal survival of one of the commonest malignancies of the world, head neck squamous cell carcinomas (HNSCC), has prompted researchers to probe into its various characteristics, especially those which reflect the outcome. Over the years, even though epidermal growth factor receptor (EGFR) and tumor-infiltrating lymphocytes (TIL) have emerged as useful biomarkers of the disease, the two parameters have rarely been considered in conjunction. Aims and Objectives: The study aimed to assess if there is any correlation between TIL levels (both stromal and intratumoral) and site, grade, stage, and EGFR score of HNSCC. Materials and Methods: A retrospective observational study was conducted in which histopathologically confirmed cases of HNSCC were included. The site of tumor, grade, stage, stromal and intratumoral TIL levels, and EGFR score were noted for each case. The data were analyzed using standard statistical tests. Results: The study population consisted of 122 patients with a mean age of 53.8 ± 9.2 years. The oral cavity was the commonest site of tumor (109 cases, 89.3%). Most cases were moderately differentiated (75, 61.5%). Pathological staging showed 66 cases (54%) to be in pT1, and 92 cases (75.4%) to be in pN0. In 68 cases (55.7%), stromal TIL level was high, and intratumoral TIL was low in 102 cases (83.6%). A statistically significant correlation was found between TIL levels and site, grade, pathological stage, and EGFR score of HNSCC. Conclusion: This pioneering study is unique in its exploration of the correlation between two significant biomarkers of HNSCC – TIL and EGFR score.
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    A randomized controlled trial to assess the efficacy of 12-hour magnesium sulphate therapy compared to 24-hour regimen on maternal outcome among patients with eclampsia admitted in a tertiary care centre
    (Medip Academy, 2024-08) Bhattacharjee, A.; Ray, J.; Chakrabarti, S.; Ray, D.
    Background: Magnesium sulphate (MgSO4) is the most popular anti-convulsant drug for treatment of eclampsia. Pritchard regimen is the most widely used regime worldwide where maintenance dose of MgSO4 is administered for 24-hour after delivery or last fit (whichever is later). As the duration of MgSO4 therapy increases, the incidence of adverse effects also increases. Therefore, the present study has been conducted to compare the maternal outcome with decreased duration of MgSO4 therapy for 12-hour with that of 24 hours for patients with eclampsia. Methods: It was an experimental study which was performed as a single centered, open labelled hospital based randomized control trial. It was conducted for 2 years (December 2019 to November 2021) among the patients of eclampsia admitted at department of obstetrics and gynaecology, AGMC and GBPH. Results: No cases of recurrent seizures in either group with additional benefit of lesser adverse effect of toxicity of MgSO4 in the 12-hour group. Conclusions: In the present study, it has been seen that 12-hour MgSO4 maintenance therapy is as efficacious as standard 24 hours therapy in controlling seizure as there was no case of recurrent seizure in either group.
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    A study to assess the effectiveness of educational training for nurses regarding non-invasive positive pressure ventilation
    (Medip Academy, 2025-01) Mehna, S; Gauba, A; Chakrabarti, S.
    Background: The use of non-invasive positive pressure ventilation (NIPPV) has significantly increased in the last three decades, becoming an essential, cost-effective tool for managing respiratory failure. The study aimed to evaluate the impact of an educational training program in improving nurses' knowledge and attitude towards non-invasive positive pressure ventilation (NIPPV) therapy. Methods: A quasi-experimental study with single group pre and post intervention conducted from 01 May 2023 to 30 June 2023 with 42 nurses, working at respiratory unit selected through enumerative sampling technique. The educational program followed the recommendation proposed by NIPPV guidelines and included six hours of theoretical and hands on training sessions. Nurses’ knowledge and attitude were assessed using a questionnaire developed by the researcher. Administrative approval was obtained from the authority and informed consent taken from all the participants. Results: Study findings reveals that there was substantial improvement in the pre and post training overall knowledge scores of nurses regarding different aspects of NIPPV therapy (15.31±3.28-26.93±1.69, with mean difference 11.62±3.56, 95% CI- 10.51-12.73, t- 21.15 p<0.001 respectively). In terms of attitude, the proportion of participants with positive attitudes increased from 0% pre-training to 100% (p<0.001) post-training. Conclusions: The educational program has proven to be a valuable asset to the nursing team in the respiratory unit. It has enhanced evidence-based practices and the quality of care, resulting in improved effectiveness, timeliness, and safety. The study findings confirm that the program effectively enriches nurses' knowledge and attitudes.