Browsing by Author "Can, Nuray"

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    Potential predictor of prognosis in breast carcinoma: Tumor budding
    (Wolters Kluwer - Medknow, 2025-06) Usta, ?nci; Yalta, Tülin D.; Can, Nuray; Süt, Necdet; Ta?tekin, Ebru; Puyan, Fulya Ö.; Usta, Ufuk; Erdo?an, Ezgi G.; Demirta?, Elif M.; Ba???, Merve; Özcan, Erkan; Çiçin, ?rfan
    Background: Breast cancer is the most common cancer in women, with invasivebreast carcinoma of no special type (IBC?NST) accounting for the majorityof cases. Aim: This study aimed to evaluate the relationship between tumorbudding (TB), which is the earliest histological indicator of tumor spread andrepresents epithelial–mesenchymal transition, and prognostic factors as wellas the effect of TB on survival in patients with IBC?NST, thereby demonstratingits potential prognostic value. Materials and Methods: This study included278 cases of breast resection diagnosed with IBC?NST from 2014 to 2019.Total tumor buds were counted in 10 high?power fields of a hematoxylin andeosin–stained section with the most infiltrative area at 400× magnification.The cutoff value for TB was obtained using receiver operating characteristicanalysis for mortality and recurrence risk; this cutoff value was used to classifyTB into two categories: low and high grades. The relationship between TBand prognostic factors and the effect of TB on the survival of patients wereinvestigated. Results: This study revealed a statistically significant relationshipbetween high?grade TB and increased tumor size, advanced pathologicalprimary tumor (pT) category, lymph node metastasis, lymphatic invasion, bloodvessel invasion, increased recurrence, and mortality as well as reduced overalland disease?free survival. Conclusion: TB in breast carcinomas may havesignificant predictive value for prognosis. It emerges as a simple, reproducible,and cost?effective histological marker. With the standardization of evaluationcriteria, TB may be readily integrated into routine pathological examination,thereby increasing its value in clinical patient management.