Browsing by Author "Bigoniya, P."
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Item Comparative Antidiabetic Potential Assessment Of Herbal Formulation Of Gymnemic Acid And Curcumin(MRI Publication Pvt. Ltd., 2019-05) Shukla, A.; Sachan, M.; Bigoniya, P.Standardization of polyherbal formulations with respect to bioactive phytocompounds is the need of the time for registration and marketing authorization in developed countries. This has prompted to prepare and evaluate a standardized bioactive phyotcompounds conintaining formulation. The study aims at development and screening of a standardized antidiabetic suspension containing active isolated phytoconstituents targeting better therapeutic effect with reduced bioburden. Suspension of isolated gymnemic acid and curcumin (GCS) was prepared, evaluated and authenticated by TLC and HPTLC. Antidiabetic efficacy of GCS was screened against alloxan induced diabetes on rats following 28 days of treatment comparative to Hyponidd tablet and Madhumehari granules. Body weight, relative organ weight, blood glucose, cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL), low density lipoprotein (LDL) and very low density lipoprotein (VLDL) level was measured. The formulation having pH 6.0, refractive index 1.41 and 45.58 mg/ml total solid content showed high alcohol and water soluble extractive value. The GCS treatment normalized liver and kidney weight, decreased body weight gain, TC, TG, LDL and VLDL level along with an increase in HDL level. Study outcome signifies similar antidiabetic potential of standardized formulation GCS compared to marketed Polyherbal formulation with antihyperlipidemic activity signifying as a promising natural and safe remedy for the prevention of diabetic complications.Item Physicochemical Properties and in Vitro Anti-Obesity Potential of Anethum Graveolens (Dill) Seed Cake(Meral Publisher, 2024-06) Awasthi, A.; Bigoniya, P.; Gupta, B.The present study investigates the in vitro anti-obesity potential of Anethum graveolens L. (Family Apiaceae) dill seed cake (DSC). DSC contained dietary fibers, proteins, lignans, and phenolic compounds. Food rich in dietary fiber is vital in lowering dyslipidemia, complications of metabolic disorders, and obesity. DSC was obtained after oil extraction of the dill seed. Physicochemical characterization and lignan profiling were performed by HPLC. An In vitro study assessed the degree of hydrolysis, ?- amylase, ?-glucosidases, and pancreatic lipase inhibitory activity. The DSC has high dietary fiber, moderate protein, and less than ten percent moisture, ash, and fat content with low foreign matter. HPLC chromatogram of DSC showed the presence of lignin-like carvone, perillyl alcohol, perillaldehyde, and cineole. The IC50 value for ?-amylase, ?-glucosidase, and pancreatic lipase inhibitory activity was 60.18 ± 2.21, 456.42 ± 5.32, and 54.13 ± 2.25 µg/ml, respectively. DSC can ameliorate obesity and associated metabolic complications by inhibiting intestinal carbohydrate and fat metabolism and absorption. Study findings provide a basis for developing dill seed as a nutraceutical supplement for obesity management.