Browsing by Author "Bhattacharya, M K"
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Item Acute diarrhoea caused by Vibrio mimicus in Calcutta.(1993-08-01) Mitra, U; De, S P; Bhattacharya, M K; Dutta, P; Dutta, D; Rasaily, R; Banerjee, D; Nag, A; Chowdhury, A S; Bhattacharya, S KOut of 539 acute diarrhoea cases studied, Vibrio mimicus was isolated as a sole pathogen in the faeces of 7 (1.3%) cases. The chief clinical presentations of the seven cases were watery diarrhoea and vomiting. Bloody diarrhoea was observed in 2 (28.5%), abdominal pain in 2 (28.57%) and fever in one (14.29) cases. All cases could be effectively treated with ORS except 3 (42.85%) cases who required IV Ringer's lactate. All V. mimicus strains isolated in the study were uniformly susceptible to tetracycline, chloramphenicol, norfloxacin and ciprofloxacin.Item Acute secretory traveller's diarrhoea caused by Vibrio cholerae which does not belong to the O1 or O139 serogroup.(1998-09-21) Bhattacharya, M K; Dutta, D; Deb, A; Garg, P; Chakraborty, S; Mukhopadhyay, A K; Bhattacharya, S K; Moitra, AItem Aetiological studies on hospital inpatients with secretory diarrhoea in Calcutta.(1992-01-01) Basak, S; Chakraborty, P S; Chandy, J; Bhattacharya, M K; Rasaily, R; Ramamurthy, T; Sen, MTwenty-five cases of all age groups with secretory diarrhoea admitted to the Infectious Diseases Hospital, Calcutta were studied. Bacterial enteropathogens were detected by bacteriological examination of the faeces, in each and every case. The main pathogens detected were Escherichia coli and Vibrio cholerae. V cholerae was more commonly associated with severe illness except in the very young, while Esch coli was equally associated with moderate and severe illness. Multiple isolates were more commonly associated with severe illness and single isolates were more common in illness of moderate severity.Item Antibody response to lipopolysaccharide antigen in Shigella dysenteriae type 1 infection.(1988-07-01) Sinha, A K; Bhattacharya, S K; Saha, M R; Bhattacharya, M K; Sen, D; Ghosh, A C; Pal, S CItem Assessing the cause of in-patients pediatric diarrheal deaths: an analysis of hospital records.(1995-03-01) Dutta, P; Mitra, U; Rasaily, R; Bhattacharya, S K; Bhattacharya, M K; Manna, B; Gupta, A; Kundu, BRecords of all the diarrheal patients up to the age of 5 years who were admitted to and died in Dr. B.C. Roy Memorial Hospital for Children, Calcutta, between January and December 1990 were analyzed. The records were reviewed to assess the relative importance of three clinical types of diarrhea (acute watery diarrhea, acute dysentery and persistent diarrhea) as the causes of mortality. Annual hospital death rates of children suffering from acute watery diarrhea, dysentery and persistent diarrhea were 13.6%, 18.2% and 25.9%, respectively. Overall death rates in dysentery (p = 0.03) and persistent diarrhea groups (p < .00001) were significantly higher than watery diarrhea group. Maximum deaths occurred among children aged between 7 and 36 months in all categories of diarrhea. Shigella infected children had higher case fatality rate. In acute watery diarrhea, 30.9% cases were assigned to associated causes of death whereas the same could be assigned to 92.6% and 93.2% cases in dysentery and persistent diarrhea group, respectively. Deaths occurred in most of the cases who had bronchopneumonia as underlying cause, septicemia as immediate cause and protein calorie malnutrition as associated cause and these were most frequently associated in patients suffering from dysentery and persistent diarrhea. Only 2.0% children suffering from acute watery diarrhea had dehydration at the time of death. Significantly, a high percentage of deaths occurred among malnourished children who suffered from dysentery (54.4%) and persistent diarrhea. These data suggest that Diarrheal Disease Control Programme should also give emphasis on management of non watery, non-dehydrating type of diarrhea with complications.Item Blood group and shigellosis.(1991-06-01) Sinha, A K; Bhattacharya, S K; Sen, D; Dutta, P; Dutta, D; Bhattacharya, M K; Pal, S CA study on the distribution of ABO blood groups was carried out on 85 patients with clinically and bacteriologically proven shigellosis. A significant association (P less than 0.01) of blood group B was observed with shigellosis cases in comparison to controls from whom no Shigella species or other enteropathogen could be isolated. Patients with isoagglutinin B or those who possess blood group B antigen may be at a relatively increased risk of shigellosis.Item Campylobacter pyloridis in samples of endoscopic biopsy in patients with upper gastrointestinal tract disease.(1986-12-01) Nair, G B; Bhattacharya, S K; Dutta, P; Sen, J K; Dutta, D; Bhattacharya, M K; Bhadra, R K; Pal, S CItem Clinical manifestation of Clostridium difficile enteritis in Calcutta.(1991-09-01) Bhattacharya, M K; Niyogi, S K; Rasaily, R; Bhattacharya, S K; Dutta, P; Nag, A; Pal, S C233 cases with acute diarrhoea investigated, Clostridium difficile was isolated as a sole pathogen from 17 (7.3%) cases. The Major clinical features of these cases were watery diarrhoea (82.4%), bloody stool (17.6%), vomiting (64.8%), fever (17.6%) and abdominal pain (2.5%). Fourteen (82.4%) of 17 C difficile isolates were found to produce cytotoxin as detected by Verocell assay.Item Clinical manifestations of campylobacter enteritis in Calcutta.(1985-07-01) Bhattacharya, S K; Nair, G B; Datta, P; Datta, D; Bhattacharya, M K; Bose, R; Pal, S CItem Clinical presentation of shigellosis during the 1984 epidemic of bacillary dysentery in West Bengal.(1987-03-01) Dutta, P; Bhattacharya, S K; Dutta, D; Sen, D; Saha, M R; Nair, G B; Bhattacharya, M K; Bose, RItem Clostridium difficile in antibiotic associated pediatric diarrhea.(1994-02-01) Dutta, P; Niyogi, S K; Mitra, U; Rasaily, R; Bhattacharya, M K; Chakraborty, S; Mitra, AA case control study was carried out at the medical wards of Dr. B.C. Roy Memorial Hospital for Children, Calcutta, between January and September 1989. One hundred eleven hospitalized children up to the age of 5 years, receiving antibiotics for different medical problems, developed antibiotic associated diarrhea. Isolation of Clostridium difficile as sole pathogen was very low (3.6%) from these patients. Fecal samples of 111 case matched control children were also screened for C.difficile. Only 2.7% fecal samples of control children were positive for C.difficile. All the strains of C.difficile isolated from antibiotic associated diarrhea cases showed neutralisable cytotoxin in in vitro test. In contrast none of the strains isolated from control children showed cytotoxicity. This study suggests that C.difficile is not an important pathogen related to antibiotic associated diarrhea in children at this hospital.Item Comparative efficacy of three different oral rehydration solutions for the treatment of dehydrating diarrhoea in children.(1988-03-01) Dutta, P; Dutta, D; Bhattacharya, S K; Bhattacharya, M K; Sinha, A K; Mondal, B C; Pal, S CItem Diarrhoeagenic campylobacters in hospitalized dysentery patients in Calcutta.(1987-01-01) Nair, G B; Bhattacharya, S K; Datta, P; Bhadra, R K; Bhattacharya, M K; Pal, S CItem Diarrhoeal diseases in Calcutta.(1992-03-01) Rasaily, R; Bhattacharya, M K; Bhattacharya, S K; Debnath, A; Pal, S CItem Distribution of age-specific rotavirus antibody in human: a hospital-based study in Calcutta.(1995-08-01) Saha, M R; Bhattacharya, S K; Bhattacharya, M KSera obtained from 332 non-diarrhoeic individuals belonging to different age groups were tested by enzyme-linked immunosorbent assay method for detection of rotavirus antibody. All the sera were found to contain rotavirus antibody in varying titres, the highest being recorded in neonates which declined to the lowest by the age of 6 months with a rapid rise during the next 5 years. This study indicates the acquisition of rotavirus antibody in different age groups.Item Effect of protein rich diet during acute phase of dysentery.(1990-01-01) Datta, D; Datta, P; Bhattacharya, S K; Mitra, U; Bhattacharya, M K; Sen, D; Sinna, A K; Manna, B; Mitra, A K; Lahiri, MNinety six children upto the age of five years suffering from uncomplicated acute dysentery of less than 3 days' duration were studied to find out the impact of feeding of extra-protein rich diet during their acute phase of illness. These children were randomly allocated to either control group (receiving only hospital diet) and study group (receiving hospital diet and extra milk which constituted 30% of ideal total calorie requirement of patients. Patients in the two groups were comparable on admission. Forty percent reduced food intake was observed among the children of both the groups due to severe anorexia which was reflected by no significant differences in clinical outcome, anthropometrical measurements and haematological parameters between the two groups on day 7 of hospitalisation and on day 15 after discharge.Item Efficacy & safety of glycine fortified oral rehydration solution in the treatment of acute dehydrating diarrhoea in children.(1989-12-01) Bhattacharya, S K; Dutta, P; Bhattacharya, M K; Mukherjee, H N; Dutta, D; Sinha, A K; Mitra, U; Nashipuri, J N; Pal, S CEfficacy and safety of glycine fortified oral rehydration solution (ORS) was compared with a standard ORS (WHO formula) in a randomized clinical trial in children aged between 4 months and 5 yr with moderate degree of dehydration owing to acute watery diarrhoea. No significant differences (P greater than 0.05) were observed in diarrhoeal stool output, duration of diarrhoea and intake of ORS between the study and control groups respectively. Thus glycine fortified ORS does not have any additional advantage over standard ORS. Moreover, two children developed hypernatraemia after receiving glycine fortified ORS in contrast to the control group. It is therefore suggested that glycine supplemented ORS should not be prescribed for the treatment of diarrhoeal dehydration in children.Item An El Tor cholera outbreak in Maldah district, West Bengal.(1999-03-16) Gupta, D N; Sarkar, B L; Bhattacharya, M K; Sengupta, P G; Bhattacharya, S KAn outbreak of cholera occurred in Maldah district, West Bengal during July-August 1998. Attack rate was 34/1000. Cases were more (59.3%) amongst adults (> 15 years.). V. cholerae 01 biotype E1 Tor serotype ogawa was isolated as a single pathogen from 52.9% (9/17 samples examined). All V. cholerae strains belonged to phage type 2 (Basu and Mukherjee scheme) and type 27 (new phage type scheme). The strains were resistant to co-trimoxazole, furazolidone, ampicillin, streptomycin and nalidixic acid.Item Emergence of multidrug-resistant Shigella dysenteriae type 1 causing sporadic outbreak in and around Kolkata, India.(2003-03-20) Dutta, D; Bhattacharya, M K; Dutta, S; Datta, A; Sarkar, D; Bhandari, B; Bhattacharya, S KItem Epidemic of Vibrio cholerae 0139 in Calcutta.(1994-11-01) Bhattacharya, S K; Goswami, A G; Bhattacharya, M K; Dutta, D; Deb, A; Deb, M; Sircar, B K; Chowdhury, A S; Das, K P; Nair, G BAs one of large outbreaks of cholera-like illness in the Indian subcontinent, Calcutta and its neighbouring areas experienced an unprecedented epidemic due to a new strain of V. cholerae non-01, designated as V. cholerae 0139 Bengal, since January 1993. This epidemic predominantly affected the adult population of Calcutta as evidenced by the hospitalization of more adults at the Infectious Disease Hospital, Calcutta (IDH), which bore the main brunt of the epidemic in and around Calcutta. During the peak of the epidemic about 180 to 300 diarrhoea patients were admitted daily at the IDH. Of the 807 patients screened, 407 were positive for V. cholerae 0139 and majority (82.8%) of the cases were > 10 yr of age. Severe dehydration was recorded in 85.5 per cent of the cases.
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