Browsing by Author "Bhatnagar, Shrish"

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    Current status of anti-diarrheal and anti-secretory drugs in the management of acute childhood diarrhea.
    (2006-08-29) Alam, Seema; Bhatnagar, Shrish
    Each year 1.8 million children die due to diarrheal diseases. Indiscriminate use of antibiotics has resulted in increasing resistance to commonly used antibiotics. Moreover the recent outbreaks of shigella and cholera have revealed multi-drug resistance strains. There is a need for review of recommended antibiotics for shigellosis. From recent data it emerges that fluoroquinolones should be the first line of therapy and cephalosporins to be used as the second line. Among the anti-cholera antibiotics, tetracyclines which were the drug of choice for adults, has the advantage of high sensitivity and low cost. Single dose doxycycline would have minimal side effects, hence can be the drug of choice even in children. We should not allow the business pressures to force usage of probiotics and racecadotril as their role in the management of acute diarrhea is yet to be established. Nitazoxanide has high efficacy against Cryptosporodial diarrhea only. Strict adherence to the recommendations for the management of acute childhood diarrhea is needed or else we dilute the effect of standard management.
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    Does H. pylori therapy augments the effect of iron therapy among children with iron deficiency anemia?
    (Medip Academy, 2020-04) Husain, Arif; Bhatnagar, Shrish
    Background: To assess beneficial effects of H. pylori therapy on children with pre-existing Iron Deficiency Anemia (IDA).Methods: A total of 218 consecutive patients with iron deficiency anemia (Hb 6-11 gm/dl) were invited to participate in the study. Patients underwent endoscopic biopsy and rapid urease test for H. pylori detection. A total of three groups were formed- Group I (n=13) - positive for H. pylori, underwent treatment for H. pylori therapy and IDA, Group II (n=16) - positive for H. pylori, underwent treatment for IDA only, Group III (n=101) - negative for H. pylori, underwent treatment for IDA only. All the patients were followed up after every 4 weeks till week 12. Change in haematological parameters and anaemic and iron status was assessed. Chi-square paired 't'-test and ANOVA were used using SPSS 21.0.Results: All the 3 groups showed a significant increase in S. Hb, Ferritin and iron levels and a decrease in S. TIBC levels. At 12 weeks, mean S. ferritin and S. iron levels were significantly higher in Groups I and III as compared to Group II while Mean S. TIBC levels were significantly higher in Group II as compared to that in Groups I and II. A total of 73.3% of Group III, 53.8% of Group I and 56.3% of Group II patients had hemoglobin levels >11 g/dl, but difference was not significant (p=0.175).Conclusions: The findings of study showed that H. pylori therapy augments the effect of iron therapy among H. pylori positive children with iron deficiency anemia.
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    Heterotopic chondroid tissue in the uterus.
    (2008-10-15) Sethi, Shipra; Bhatnagar, Shrish; Sethi, Shiny
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    Polyethylene Glycol vs. Lactulose in Infants and Children with Functional Constipation
    (Indian Academy of Pediatrics, 2019-05) Bhatnagar, Shrish
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    Tropical pulmonary eosinophilia-mimicking acute severe asthma: a case report
    (Medip Academy, 2024-07) Roy, Poulomi; Verma, Shalini; Bhatnagar, Shrish
    Tropical pulmonary eosinophilia (TPE) is a rare but serious infection characterized by wheezing, fever, and eosinophilia, with clinical features such as paroxysmal cough, wheezing, and dyspnoea. TPE is diagnosed by a history of filarial endemic regions and peripheral eosinophilia >3,000/mm3. It can be easily missed but can be a differential for bronchial asthma and tuberculosis. A 15-year-old male with cough and breathlessness for three years was diagnosed with TPE after laboratory investigations showed leucocytosis with eosinophilia. A provisional diagnosis was considered, and diethylcarbamazine (DEC) was started at a dose of 6 mg/kg body weight for 21 days, with improvement in the patient's symptoms. TPE affects 51.4 million people globally and is often misdiagnosed as other conditions like bronchial asthma, military tuberculosis, and interstitial lung disease. The diagnostic criteria for TPE include a history of residence or travel to a filarial endemic region, paroxysmal and nocturnal cough with dyspnoea, leucocytosis with peripheral blood eosinophilia>3000/mm3, elevated serum IgE and filarial antibody titres, pulmonary infiltrations in chest X-ray, and clinical improvement with DEC.