Browsing by Author "Bhatnagar, Sharad"

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    High-Dose-Rate Intracavitary Brachytherapy Boost Post-External Beam Radiotherapy Using Rotterdam’s Applicator In A Case Of Recurrent Carcinoma Nasopharynx
    (Atharva Scientific Publications, 2019-01) Sharma, Shweta; Bhatnagar, Sharad; Nilkanthan, Ajith; Semwal, Manoj; Singh, Sankalp
    Long-term local control is possible in a highly radio-responsive tumor-like carcinoma of the nasopharynx, even in the recurrent setting. High-dose-rate brachytherapy boost with its steep dose fall-off helps achieve salvage by providing optimal dose coverage to the tumor volume which is in close anatomic proximity to critical structures at the base of the skull. Here, we report the case of a 58-year-old lady, an old case of carcinoma nasopharynx presented with recurrence of symptoms in the form of nasal blockade along with a right pre-auricular swelling. Further evaluation showed an fluorodeoxyglucose-avid nasopharyngeal mass, a biopsy from which was positive for nasopharyngeal carcinoma (NPC). She first received re-radiation with external beam radiotherapy using 6 MV photons to the face and neck along with concurrent chemotherapy withcisplatinfollowed by brachytherapy boost with Rotterdam’s Brachytherapy Applicator @5 Gray×2# 1 week apart. Brachytherapy is a feasible tool that allows dose escalation to achieve long-term tumor control in locally advanced NPCs.
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    Low-grade malt lymphoma of the nasopharynx in young adults: Successful treatment of a rare diagnosis at a rare site by radiotherapy
    (Wolters Kluwer - Medknow, 2024-01) Singh, Sankalp; Bhatnagar, Sharad; Bisht, Niharika; Kapoor, Amul; Mishra, Prabha Shankar; Lohia, Nishant
    Introduction: Mucosa Associated Lymphoid Tissue (MALT) lymphoma is the third most common subgroup of Non?Hodgkin’s lymphoma and is the most common type of primary extranodal lymphoma. They are rarely found in the nasopharyngeal region and their mean age at presentation is the sixth decade of life. Materials and Methods: We present the clinical, pathological, treatment and 5?year follow?up data of 5 cases of nasopharyngeal MALT lymphoma treated with definitive radiotherapy at our hospital, between 2009 and 2011. Results: The average age of diagnosis was 27 years which is more than a decade earlier than what has been reported previously. Clinical symptoms included nasal obstruction, tinnitus and hearing loss. All five patients had locoregional disease. They were treated by definitive radiotherapy to a dose between 30 to 40 Gy. At 5 years of follow?up, 4 patients were in complete remission while one had disease relapse. Conclusion: The younger age of presentation compared to older reports in this rare subsite was an interesting finding in our study. The authors speculate that rising levels of particulate air pollution may have played a part in the etiology in this younger population. Our series shows that despite the younger age, the disease displays an indolent course and responds well to radiotherapy alone as the primary treatment. Recurrence or disseminated disease is also highly treatable with systemic chemotherapy.