Browsing by Author "Batra, Jyoti"
Now showing 1 - 3 of 3
Results Per Page
Sort Options
Item Effect of Iron Deficiency Anemia on Hba1c Levels in Controlled Plasma Glucose Levels(Society for Health Care & Research Development, 2019-03) Khare, Manika; Thakur, Ajit; Batra, Jyoti; Yadav, Pratibha; Dhanetwal, Murari lal; Sayed, M AliAnaemia is a major health issue that has a wide global impact involving approximately 1/3rd of patients with anaemia. HbA1C levels are not influenced by blood glucose levels alone. Studies suggest that conditions like IDA, haemolytic anaemia, alcohol ingestion, pregnancy, blood loss, and uraemia may alter HbA1C levels independent of glycaemic status. Methods: Totally 200 patients were included in the study.. 100 patients were controlled diabetics with iron deficiency anemia and 100 were controlled diabetics without iron deficiency anemia. Comparison of levels of HbA1c was done between the two groups. Results: Correlation between mcv and hba1c is -0.76716. Which is strongly negative correlated. P – Value for the correlation test is 0.000001. Conclusion: Iron deficiency anemia has role in elevating A1C in both the groups. Iron deficiency anemia elevates HbA1c levels in diabetic individuals with controlled plasma glucose levels. The elevation is more in patients having plasma glucose levels between 100 to 126 mg/dl. Hence, before altering the treatment regimen for diabetes, iron deficiency anemia should be treated first.Item Evaluation of the safety and efficacy of codeine phosphate and chlorpheniramine maleate in a fixed dose composition for the management of dry cough in adults: an open label phase IV clinical trial(Medip Academy, 2023-02) Kumar, Ashok; Batra, JyotiBackground: Dry cough is one of the most common symptoms for which patients seek medical attention. It not only, causes discomfort in patients, but also hampers their daily work and routine. Since there is no specific underlying cause, for dry cough, a definitive treatment is still not available. Several cough suppressants have been used for the treatment, of dry cough including codeine which reduces discomfort. However, some reports suggest that use of codeine at high, doses leads to sedation and drowsiness. To evaluate the safety and efficacy of codeine, a clinical trial for fixed dose, composition of codeine phosphate and chlorpheniramine maleate was conducted., Methods: The trial was conducted on 219 adults with prior symptoms of dry cough. Safety was evaluated on the basis, of the change in patient’s vital parameters, any adverse event or severe adverse event that occurred during the course, of study. Efficacy was assessed on the basis of cough severity scores, number of night awakenings due to cough, and, overall decline in cough., Results: According to the investigator's evaluation the product was safe to use as no significant changes in the patient’s, vital parameters were observed during the course of study. Also, no severe adverse events were reported. Administration, of the investigation product significantly decreased cough severity and frequency at the 7 th day of the study., Conclusions: This study suggests, FDC of codeine phosphate 10 mg and chlorpheniramine maleate 4 mg per 5 ml oral, syrup is safe and efficacious for the treatment of dry cough.Item Lead Associated Nephrotoxicity: A Global Concern(Society for Health Care & Research Development, 2018-11) Thakur, Ajit; Juyal, Deepak; Sayana, Ashutosh; Thaledi, Shweta; Batra, JyotiAmongst toxic heavy metals, lead ranks as one of the most serious environmental poisons all over the world. An occupational and environmental exposure to lead remains a serious problem in many developing and industrializing countries, as well as in some developed countries. Lead exposure can be detrimental to every organ in the human body with kidney and brain being predominantly susceptible to its deleterious effects. An association between lead poisoning and renal diseases in humans has been recognized and documented by several studies. Excessive exposure to lead may cause acute or chronic nephrotoxic effects. Studies suggest that prolonged lead exposure may be an overlooked risk factor for chronic kidney disease. Majority of lead associated renal toxicity are a result of the previous chronic exposure, ongoing chronic exposure or current high acute exposure to lead. Both glomerular and tubular effects have been reported. Glomerular effects range from high molecular weight proteinuria to a nephritic syndrome whereas tubular changes consist of an enhanced urinary excretion of enzymes. Lead poisoning and associated nephrotoxicity is an important and preventable health problem that remains to be fully addressed. However due to lack of education regarding the dangers of working with lead or lead containing products, potential health hazards of lead poisoning still exist and are rising in India. The regulatory bodies should be more vigilant and make it mandatory to evaluate and create awareness among the workers as well as general population about the lead toxicity and should insist on regular health checkups to prevent adverse health effects.