Browsing by Author "B., Lakshminikhila"

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    An Observational Cohort Study on Prescription Patterns of Intravenous Albumin Use in Different Indications of Liver Disease
    (Ibn Sina Academy of Medieval Medicine & Sciences, 2023-02) B., Ravi Shankar; B., Lakshminikhila; G., Sailipi; Rampally, Vijay; E., Madhu Sudhan
    Introduction: Albumin is administered 20% as a part of treatment in various indications associated with decompensated liver disease. Methods: The study was conducted on patients over six months. Data were collected from 50 patients including males and females who are administered 20% albumin for liver cirrhosis. Disease severity before and after albumin infusion was calculated using prognostic tools like Child-Pugh and MELD-Na scoring system. Results: Among 50 patients, a major percent of patients were found to be HRS (28%) for albumin infusion and few extended indications were noticed; Decompensated liver cirrhosis without any other complications (18%), HE (18%), Hyponatremia (16%). After albumin infusion for six months, prognostic tools (CPT and MELD-Na scores) and laboratory parameters (serum creatinine, serum sodium, serum albumin) were significantly improved with P-value less than 0.05. Conclusion: Albumin usage has increased in some extended indications like decompensated liver cirrhosis without any other complications, hyponatremia, hepatic encephalopathy. Doses used in the present study were significantly less (when compared to standard doses as per the clinical guidelines) to minimize the adverse effects of albumin primarily pulmonary edema due to volume overload. Our study was consistent with the ANSWER trial where 20% albumin was used for the long term in decompensated liver cirrhosis.