Browsing by Author "Ayushi"

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    Incidence-and-complications-of-emergency-obstetric-hysterectomy
    (INDIAN SOCIETY FOR HEALTH AND ADVANCED RESEARCH, 2024-07) Ayushi; Deshmukh, Ashvini; Shivani; Khedkar, Charul
    Background: Emergency obstetric hysterectomy (EOH) is a life-saving procedure performed for uncontrolled postpartum hemorrhage or infection. Understanding the epidemiology and outcomes of EOH is crucial for quality improvement. We aimed to determine the incidence, indications, complications, and risk factors for EOH at our center. Methodology: This retrospective cross-sectional study analyzed all cases of EOH over a 5-year period at a tertiary hospital. Data on indications, complications, and maternal outcomes were extracted from medical records. OfResults: 1500 deliveries, 30 underwent EOH (incidence 2%). The leading indication was uterine atony (56.7%). Major complications occurred in 13 patients (43.3%), including 8 cases of fever, 5 wound infections, and 2 mortalities. Grand multiparity and lack of antenatal care were significantly associated with EOH (p<0.05). The EOH rate of 2%Conclusion: demonstrates the life-saving role of this surgery, but the 43.3% complication rate highlights associated risks. Improving access to family planning services and antenatal care, prompt management of postpartum hemorrhage, infection control practices, and emergency obstetric care capacity are essential to reduce the incidence and morbidity of EOH.
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    Proposed Vaccine for Mental Health: From Green Tea
    (Sumathi Publications, 2025-03) Ayushi
    Mental health is one of the major concerns prevailing now-a-days, both, at national level and global level. Specially, after COVID-19, this concern has raised to an alarming level, and needs to be worked upon. Although, there are various therapies and medications against mental disorders. But, those medicines have their own side effects also. We need to take some extra step towards the root of these mental disorders, which is 憄sychological stress�. Psychological stress is not only the root of various mental disorders, but also, a few physical health issues, such as type-2 diabetes mellitus, cardiovascular diseases, cancer, etc. That抯 why; we do need therapeutic agents and their target against psychological stress. A few publications on PubMed claimed that, green tea has a few such natural components. Two phytochemicals of green tea 慶affeine� and 慙-theanine�, acts on brain, and can positively influence mood and cognition. Both these components in this research were studied using 慞ubChem� and 慉DMETlab2.0�. Caffeine mainly enhances arousal, alertness, and, attention-switching. While, L-theanine can increase the level of happiness promoting neurotransmitters in brain, which are serotonin, dopamine and GABA, as suggested by 慞ubChem�. ADMETlab2.0 suggests the overall safety of both these phytochemicals on human body. So, the final conclusion of this research was that, mainly 慙-theanine� as key component or 慙-theanine� and 慶affeine� together, isolated from green tea, can serve as 憄reventive or therapeutic vaccine� against various mental disorders and psychological stress.
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    Trends of humoral immune responses to heterologous antigenic exposure due to vaccination & omicron SARS-CoV-2 infection: Implications for boosting
    (Wolters Kluwer – Medknow, 2023-06) Batra, Gaurav; Murugesan, Deepika Rathna; Raghavan, Sreevatsan; Chattopadhyay, Souvick; Mehdi, Farha; Ayushi; Gosain, Mudita; Singh, Savita; Das, Soon Jyoti; Deshpande, Suprit; Sonar, Sudipta; Jakhar, Kamini; Bhattacharya, Jayanta; Mani, Shailendra; Pandey, Anil Kumar; Sankalp; Goswami, Shweta; Das, Asim; Dwivedi, Tanima; Sharma, Nandini; Kumar, Suresh; Sharma, Pragya; Kapoor, Seema; Kshetrapal, Pallavi; Wadhwa, Nitya; Thiruvengadam, Ramachandran; Kumar, Rakesh; Gupta, Ritu; Garg, Pramod Kumar; Bhatnagar, Shinjini
    Background & objectives: Vaccination and natural infection can both augment the immune responses against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), but how omicron infection has affected the vaccine-induced and hybrid immunity is not well studied in Indian population. The present study was aimed to assess the durability and change in responses of humoral immunity with age, prior natural infection, vaccine type and duration with a minimum gap of six months post-two doses with either ChAdOx1 nCov-19 or BBV152 prior- and post-emergence of the omicron variant. Methods: A total of 1300 participants were included in this observational study between November 2021 and May 2022. Participants had completed at least six months after vaccination (2 doses) with either ChAdOx1 nCoV-19 or an inactivated whole virus vaccine BBV152. They were grouped according to their age (? or ?60 yr) and prior exposure of SARS-CoV-2 infection. Five hundred and sixteen of these participants were followed up after emergence of the Omicron variant. The main outcome was durability and augmentation of the humoral immune response as determined by anti-receptor-binding domain (RBD) immunoglobulin G (IgG) concentrations, anti-nucleocapsid antibodies and anti-omicron RBD antibodies. Live virus neutralization assay was conducted for neutralizing antibodies against four variants – ancestral, delta and omicron and omicron sublineage BA.5. Results: Before the omicron surge, serum anti-RBD IgG antibodies were detected in 87 per cent participants after a median gap of eight months from the second vaccine dose, with a median titre of 114 [interquartile range (IQR) 32, 302] BAU/ml. The levels increased to 594 (252, 1230) BAU/ml post- omicron surge (P<0.001) with 97 per cent participants having detectable antibodies, although only 40 had symptomatic infection during the omicron surge irrespective of vaccine type and previous history of infection. Those with prior natural infection and vaccination had higher anti-RBD IgG titre at baseline, which increased further [352 (IQR 131, 869) to 816 (IQR 383, 2001) BAU/ml] (P<0.001). The antibody levels remained elevated after a mean time gap of 10 months, although there was a decline of 41 per cent. The geometric mean titre was 452.54, 172.80, 83.1 and 76.99 against the ancestral, delta, omicron and omicron BA.5 variants in the live virus neutralization assay. Interpretation & conclusions: Anti-RBD IgG antibodies were detected in 85 per cent of participants after a median gap of eight months following the second vaccine dose. Omicron infection probably resulted in a substantial proportion of asymptomatic infection in the first four months in our study population and boosted the vaccine-induced humoral immune response, which declined but still remained durable over 10 months