Browsing by Author "Aslam, Mohammad"

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    Antimicrobial Study Of Vyadhividhwansana Rasa (an Herbomineral Preparation): In Vitro Study
    (Mahadev Publications, 2020-01) Prasad, Anjali Baijnath; Agrawal, Sachin; Aslam, Mohammad; Baheti, Sandip; Dattatray, Dighe
    Ayurveda-The traditional medicinal science in India has holistic approach and practiced widely in the subcontinent. Large parts of the Ayurvedic drugs are heromineral preparations. These preparations are broad spectrum as far as its indications are concerned. Definite mode of action of these drugs are inexplicable. Vyadhividhwansana Rasa is an herbomineral preparation used for treating acute fever, interrupted fever, fever of unknown origin, ascites, splenomegaly, colic pain, Vata vyadhi, Aama jwara (first stage of fever) and Vishama jwara (irregular fever). In view of its therapeutic indications an antimicrobial study was designed to ascertain its probable mode of action. The present study aims to evaluate the antimicrobial activity of Vyadhividhwansana Rasa against test organisms at different concentration. Vyadhividhwansana Rasa was prepared as per Ayurvedic texts. Positive control Streptomycin [5mg(w/v)] and negative control 20% dimethyl sulfoxide (DMSO) were prepared. Solution of Vyadhividhwansana Rasa were prepared in three concentrations at 50 mg/ml, 100 mg/ml and 150 mg/ml in DMSO and was tested for its antimicrobial activity against Escherichia coli, Streptococcus pyogenes, Staphylococcus aureus, Pseudomonas aeruginosa and Salmonella typhi by agar-well diffusion method. The measured Inhibition Zone ranged from 4-34 mm for all the sensitive bacteria. All the bacteria except Salmonella typhi were found Susceptible (S) against Vyadhividhwansana Rasa compared to standard. Salmonella typhi was found Intermediate sensitive (I). The antimicrobial activity of the extracts increased when the solution is more concentrated.
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    Assessment of Antidiabetic Potential of Polyherbal Formulations
    (Ibn Sina Academy of Medieval Medicine & Sciences, 2016-07) Alimoddin, Md; Ali, Wazid; Shafiuddin, Mohammed; Aslam, Mohammad; Kumar, Manish
    Introduction: Diabetes provides a major challenge to the present population globally. It is a major threat to global public health that is rapidly reaching epidemic scale. Plant based drugs are gaining importance to treat majority of human aliments including diabetes mellitus due to their less toxic effects. Aims: The present study was designed to assess the antidiabetic potential of polyherbal formulations in streptozotocin induced diabetic rats. Methods:  Diabetes was induced by single intraperitoneal injection of streptozotocin (50 mg/kg) in male Wistar rats. Rats with fasting blood glucose levels ≥ 250 mg/dl after seven days of STZ administration were randomized into different groups and were treated with Formulation-1 (F1) and Formulation-2 (F2) in graded doses for 21 days. At the end of the study, blood glucose, lipid profiles were estimated. In addition, enzymatic and non-enzymatic liver antioxidant levels were also estimated. To elucidate the mode of action, we evaluated its effects on oral glucose tolerance test in normal rats and single-dose one day-study and multiple-dose twenty one day- study in diabetic rats. Results:  The effect on the insulin level with the treatment by formulations suggests that the mode of action is a similar to that of Glibenclamide. Oral administration of F1 and F2 for 21 days significantly reduced blood glucose level in STZ induced diabetic rats. Both the formulations exhibited antihyperglycemic effect in glucose loaded rats and STZ induced rats. The blood glucose was significantly increased. Supplementation with F1 and F2 both with (250 and 500 mg/kg) showed reduction in the blood glucose levels and improved glucose tolerance, suggesting that there was an improvement in STZ-induced deleterious effects. Conclusion: This study reveals that F1 and F2 improved STZ-induced hyperglycemia, this effect may be mediated by interacting with multiple targets operating in diabetes mellitus.
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    A Comparative Study of Laryngeal Mask Airway Lubrication with Lignocaine 2% V/S Beclamethasone 005% Cream
    (Society for Health Care & Research Development, 2019-07) Khan, Fauzia Rehman; Aslam, Mohammad
    Postoperative sore throat (POST) is a minor complication after general anaesthesia. Many agents have been used as lubricant to reduce the incidence of POST with variable efficacy. Methods: We conducted a study to compare the incidence of POST with 0.05% betamethasone gel and 2% lignocaine jelly as a lubricant for LMA insertion in patients undergoing general anaesthesia. Sixty subjects were divided randomly into two groups. Patients in Group B (n = 30) had 2.5 ml of 0.05% of betamethasone gel while the Group L had 2.5 ml of 2% lignocaine jelly applied on the cuff of LMA. After standard induction and insertion of LMA cuff inflated to 60 cm of H2O and was maintained at the same throughout the surgery. Results: In PACU, patients were inquired about sore throat at immediate and 24 h post operative period. POST was not observed in any of the patients of Group B. In group L 13% of the patients had 1st degree and 3% had 2nd degree of sore-throat in immediate post-operative period. After 24 h 3%patients had 1st degree sore-throat and 1% patients had 2nd degree of sore-throat in Group L patients. Conclusion: We conclude that lubricating cuff of LMA with 0.05% of betamethasone gel is effective in reducing the incidence of POST.
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    Comparison of Two Different Technique of Interscalene Block in Orthopedic Patients Undergoing Shoulder Surgery
    (Society for Health Care & Research Development, 2019-03) Khan, Fauzia Rehman; Aslam, Mohammad
    The traditional Interscalene brachial plexus block has a 100% incidence of diaphragmatic paralysis, resulting in a 25-30% reduction in forced vital capacity (FVC). A modified or low Interscalene block is defined as a brachial plexus nerve block below C6 but above the supraclavicular fossa. The purpose of our study was to determine if a modified Interscalene block would prevent diaphragmatic paralysis while providing an adequate pain control for patients undergoing shoulder surgery. Methods: 50 patients who were scheduled to undergo shoulder surgery were incorporated in the study. Patients were randomized to receive either a low (LI) or a traditional (TI) interscalene nerve block. Both groups received 15ml of 0.5% Bupivacaine diluted to 30ml for brachial plexus block. Post-block lung function was assessed using incentive spirometry. Results: The average decrease in lung volume in the group receiving the low-modified interscalene block was 900ml, while the decrease in the traditional group was 860ml. The decrease in lung volumes between the two groups was determined to be not significant (p= 0.525). Conclusion: Low interscalene brachial plexus blockade is often described as a technique used to prevent phrenic nerve blockade and hemi-diaphragmatic paralysis. Our study found that phrenic nerve blockade was low in LI group as compared to TI group. Postoperative pain scores, respiratory complications, need for supplemental oxygen, and delay in discharge did not occur in either group. We found that LI interscalene brachial plexus blockade not better than TI interscalene block.
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    Enterolithiasis: A Rare Finding in Intestinal Tuberculosis
    (Ibn Sina Academy of Medieval Medicine & Sciences, 2016-07) Aslam, Mohammad; Faridi, Shahbaz Habib; Chaubey, Rupali; Varshney, Sandeep; Ghazanfer; Meraj; Deepak, Arun
    Though intestinal tuberculosis is relatively a common ailment in India and other developing countries; enterolithiasis is a rarely encountered clinical and radiological entity found in this disease. Enteroliths are formed due to stasis caused by stricture formation in intestinal tuberculosis. We report a case of enterolithiasis secondary to intestinal tuberculosis.
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    Functional Outcome of Paediatric Diaphyseal Fractures of Femur Treated with Closed Reduction and Multiple K Wire Fixation.
    (2016-11) Aslam, Mohammad; Khan, Fauzia Rehman; Julfiqar; Huda, Najmul; Pant, Ajay; Khan, Azad
    Background: Diaphyseal fracture of the femur in children is one of the common causes of paediatric morbidity. These fractures in children above the age of five years, depending upon the fracture personality, can usually be managed satisfactorily using different intramedullary implants, including Kirchner wires, Rush nail, as well as extramedullary implants using various combinations of plates and screws. Each of these methods of fracture fixation has its own merits and demerits. The current study is aimed at assessing the efficacy of internal fixation of these fractures using closed reduction and percutaneous ‘K’ wire fixation. Methods: Twenty six (n=26) children with a mean age of 7.2 years (range 5-14 years) were treated using closed reduction and multiple percutaneous K wire fixation under image intensifier. The minimum follow up period was twelve months. The final clinical and radiological assessment of patient was done at the end of one year. Three patients (n=3) were lost to final follow-up and were excluded from the final statistical calculations. Results: Twenty one fractures (n=21) united at an average time interval of 4.1 months (range 3- 6.5 months). Two patients had delayed union and one had malunion. Superficial wound infections were seen in two (8.7%) patients. Impingement of bent k wires was felt by another two (8.7%) patients. Stiffness of the knee joint was seen in three patients (13%) during follow-up. Out of three (n=3) patients with knee stiffness two responded well to vigorous physiotherapy programme, while one (n=1) patient had limited knee range of motion even at the final follow-up. Malunion was seen in one (n=1) patient. Conclusion: Closed reduction and percutaneous K wire fixation is a safe, economical, technically non-demanding and highly efficacious technique for the treatment of paediatric femoral diaphyseal fractures.
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    Outcome of Discectomy by Fenestration Technique in Prolapsed Lumbar Intervertebral Disc.
    (2015-10) Aslam, Mohammad; Khan, Fauzia Rehman; Huda, Najmul; Pant, Ajay; Julfiqar, Mohd; Goel, Akshat
    Background: Prolapsed disc is the major cause of low backache with radiculopathy. Many different techniques, from extensive laminectomy to minimal invasive endoscopic surgeries have been described with aim to minimize the possibility of damage to other structures. Methods: Twenty patients with clinical symptoms and signs prolapsed disc having radiological confirmation by MRI were subjected to disc excision by fenestration technique. Results: The follow-up analysis as per Modified Mac Nab’s Criteria showed excellent results in 15 patients, good in 4 patients and fair in 1. Conclusion: Discectomy by fenestration offers sufficient and adequate exposure for lumbar disc excision. Advantages over conventional discectomy are smaller incision, lesser morbidity, shorter convalescence, early return to work and comparable overall results. It can even be performed in peripheral centers where recent microscopic and endoscopic facilities are not available.