Browsing by Author "Ansari, Aatif"

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    A Rare Case Of Hemolytic Disease Of Fetus And Newborn In The Absence Of ABO Or RH(D) Conflict : A Case Report
    (Indian Society for Health and Advanced Research, 2025-06) Batra, Palak; Apte, Mohini; Ansari, Aatif; Das, Soumya; Charmode, Juilee Shalik
    Hemolytic disease of the fetus and newborn (HDFN) in the absence of ABO or Rh(D) incompatibility is an infrequent but serious complication most of the times resulting from minor Rh blood group incompatibility. The frequency of hemolytic disease of fetus and newborn and indirect hyperbilirubinemia due to Rh sensitisation has decreased with the widespread use of anti-D gamma globulin. Hence, the contribution of minor blood groups incompatibility other than Rh(D) antigen, such as Kell, c, C, E, e has gradually increased in HDFN. We report a case of early- onset severe hyperbilirubinemia in a neonate born to a mother with sickle cell disease (SS pattern) with history of multiple blood transfusions and one 1st trimester spontaneous abortion. Inspite of the absence of ABO or Rh(D) incompatibility, the neonate had developed DCT positive severe hemolytic anemia due to maternal anti-c antibodies. The neonate required two exchange transfusions and intensive phototherapy. This case highlights the need for extended antenatal red blood cell antigen typing and antibody screening, particularly in high-risk groups with transfusion-dependent conditions like sickle cell disease.
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    Study of incidence, risk factors and immediate outcome of hypoglycemia in neonates admitted in NICU
    (Medip Academy, 2023-08) Ansari, Aatif; Savaskar, S. V.; Tamboli, Moin; N., Pushpa S.
    Background: Hypoglycemia is the most common metabolic problem occurring in newborns which is associated with poor neurologic outcome. The present study was conducted to determine the incidence, risk factors and immediate outcome of hypoglycemia in neonates.Methods: The present study was conducted on 3776 babies born with risk factors for hypoglycemia in NICU. Screening for blood glucose level of study subjects were done at 2, 4, 6,12,24,48,78 hours of life, twice daily and whenever symptomatic by using glucometer. Babies were followed up till discharge. Incidence, risk factors and immediate outcome of hypoglycemia were assessed. Appropriate tests were applied.Results: Incidence of hypoglycemia was 9.93% among high-risk neonates and overall incidence was 5.20%. 54.13% were males. 45% were preterm, 78.7% neonates were LBW. 53.07% were born to primiparous mother, 20.5% to diabetic mothers and 28.5% to hypertensive mothers. 16.8% had perinatal asphyxia, 14.66% new-born had underlying RDS. 48.5% were symptomatic, most common being lethargy 52.75% followed by jitteriness 43.41%, convulsion in 63 (34.62%). Preterm and LBW were significantly associated with mortality. Most common underlying comorbidities associated with deaths were sepsis (59.10%), RDS (45.46%), perinatal asphyxia (13.64%) and meconium aspiration syndrome (4.55%).Conclusions: Neonates with one or more risk factors for hypoglycemia should be screened irrespective of symptoms within 72 hours of life. Focused counselling on early initiation of breast feeding will reduce the incidence of hypoglycemia and its complications.
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    Study on clinical profile of ventilated children in a pediatric intensive care unit of tertiary care centre
    (Medip Academy, 2023-09) N., Pushpa S.; Savaskar, S. V.; Ansari, Aatif; Parmar, Manish
    Background: Mechanical ventilation constitutes a major therapeutic modality in intensive care, so care of patients requiring ventilatory support is an integral part of the critical care unit. Very less data is available from developing countries regarding use of Mechanical Ventilation, its complication and outcomes which is a challenge for modern day intensivists. Objectives were to study clinical profile of ventilated children in a PICU of tertiary care centre. Methods: Present prospective cross-sectional study was conducted on ventilated children admitted at PICU of Dr. VMGMC hospital, Solapur. The study included demographics, clinical profile, indication for ventilation, length of hospital stays, outcome.Results: Out of 300 children, 170 were males. Most the children were from age group <5 years. Difficulty in breathing was seen in 188 cases, fever in 55%, 100 patients had acute CNS infections, 82 cases had bronchopneumonia, 85 cases respiratory failure was the indication for intubation. The duration of the mechanical ventilation was more in CNS cases, RS cases, sepsis cases. 165 cases got recovered successfully.Conclusions: Mechanical ventilation is one of the major supportive modalities used in critical care all over the world and is also used in many of the sick children in government tertiary care centre. Despite of its life saving advantages, mechanical ventilation is associated with complication. Early use of HHFNC, CPAP/BiPAP and other non-invasive modes of ventilation decrease the need for invasive mechanical ventilation.