Browsing by Author "Ali, M M"
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Item Aluminum ingestion alters behaviour and some neurochemicals in rats.(1993-01-01) Lal, B; Gupta, A; Gupta, A; Murthy, R C; Ali, M M; Chandra, S VEffect of aluminum (Al) has been investigated on the brain of rats exposed to this metal (500 mg Al/liter in drinking water) daily for 180 days. A significant reduction in the spontaneous locomotor activity was noticed after 90 and 180 days of Al exposure to the rats, the magnitude of the change being almost identical at both the time intervals. Aluminum exposure also produced significant deficits in acquisition and retention of learned response in active avoidance situation, these changes being time dependent. A significant retardation of the extinction of the learned task was noted in Al exposed rats especially at 180 days. There was significant increase in the lipid peroxidation and decrease in the activity of Mg(2+)-ATPase and Na+,K(+)-ATPase in the brain of rats at 180 days after Al exposure. The increase in the contents of the metal was maximum in rest of the brain region (87% of control) followed by hippocampus and cerebral cortex (59% of controls), cerebellum and corpus striatum (43% and 44% of controls, respectively) after 180 days. Whether Al is responsible to initiate neurotoxic effects by producing changes in the structure and function of the plasma membrane needs further investigations.Item Effect of chronic cadmium exposure on locomotor behaviour of rats.(1990-07-01) Ali, M M; Mathur, N; Chandra, S VGrowing male rats were exposed to cadmium (Cd, 100 micrograms/kg, ip) for 51 days and the effect on the different components of locomotor behaviour was assessed on days 38, 46 and 51 of Cd exposure. Significant decrease in distance travelled, stereotypic time and movements, ambulatory time and vertical movements were observed in Cd-exposed rats, whereas the time of rest was increased. The number of entries into the inner as well as the outer squares and the total time spent in the inner squares of the floor area were significantly reduced. Results indicate that Cd exposure results in a general depression in all aspects of motor behaviour leading to decrease in gross locomotor activity. The involvement of an exaggerated emotional reactivity in the behavioural expression of the Cd-treated animals is also emphasized.Item Ganglion blocking activity of a series of semisynthetic quaternary pyrrolizidines.(1977-03-01) Gupta, O P; Ali, M M; Ghatak, B J; Atal, C KItem Local anaesthetic action of some semisynthetic pyrrolizidine esters & their structure activity relationships.(1976-01-01) Gupta, O P; Ali, M M; Ghatak, B J; Atal, C KItem Neuromuscular blocking activity of a new series of semisynthetic quaternary pyrrolizidines.(1977-03-01) Gupta, O P; Ali, M M; Ghatak, B J; Atal, C KItem Neuromuscular blocking activity of semisynthetic quaternary pyrrolizidines as compared with d-tubocuraine.(1977-11-01) Gupta, O P; Ali, M M; Ghatak, B J; Atal, C KItem Pharmacological investigation of an alkaloid fraction isolated from Strychnos potatorum Linn.(1975-03-01) Ali, M M; Ghatak, B JItem Pharmacological screening of Indian medicinal plants.(1978-02-01) Sharma, M L; Chandokhe, N; Ghatak, B J; Jamwal, K S; Gupta, O P; Singh, G B; Ali, M M; Thakur, R S; Handa, K L; Rao, P R; Jamwal, P S; Sareen, Y KItem Serum pepsinogen levels in patients with gastric cancer.(1987-07-01) Habibullah, C M; Ali, M M; Jayanthi, M; Ali, H; Begum, SItem Some pharmacological investigations of embelin and its semisynthetic derivatives.(1977-01-01) Gupta, O P; Ali, M M; Ray Ghatak, B J; Atal, C KEmbelin, obtained from Embolin ribes was condensed with different primary amines. Depending on the conditions of reaction, disalts or diimines were formed. Ten such disalts and fourteen diimines were developed. Embelin and all its disalts showed analgesic activity whereas all the diimines derivatives were inactive. The disalt, 2:5 disobutyl amine embelin showed maximum action. Analgesic effect was noticed only after intraperitoneal administration but not after subcutaneous, intramuscular or oral administration. The compounds cause some local irritation. The possibility of peritoneal irritation rendering the animals unresponsive to experimental pain seems to deserve consideration. However, analgesic effect could be seen in dogs and cats after intravenous injection. Embelin and its disalt, 2:5 isobutyl amine embelin also exhibited antipyretic and antiinflammatory activities.