Browsing by Author "Akhtar, M"
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Item Cardiac arrhythmias in children.(1966-06-01) Akhtar, MItem Cardiac changes in myopathy. A ballistocardiographic study.(1970-07-01) Wahi, P L; Akhtar, MItem Cardiovascular manifestations in thyroid disorders.(1978-07-01) Akhtar, M; Singh, S J; Krishnamurti, SItem Complications in 1000 consecutive treadmill tests.(1993-08-01) Malani, S K; Roy, C P; Nath, C S; Sasikumar, M; Akhtar, MComplication in 1000 consecutive Tread Mill Tests (TMT) done at the Cardiology Centre of Command Hospital (SC) Pune are reported. The tests were done following Bruce Protocol and analysed based on Selzer's criteria. Complications were noted in 18 cases (1.8%) which included ventricular fibrillation, ventricular tachycardia, atrial fibrillation, malignant VPBs, conduction disturbances, asystole following hyperventilation (HV), complete SA block following HV, atrial flutter following HV, hypotension and severe angina requiring ICCU care. No acute myocardial infarctions or deaths were noted. Coronary arteriography (CART) was done in 50 (5.0%) selected cases including 10 with complications. It is concluded that TMT is a safe procedure if carried out after proper patient selection and under supervision of an experienced and efficient team.Item Dual exposure and repair technique for ruptured aneurysms of aortic sinus of Valsalva.(1994-01-01) Gupta, R; Khanna, S K; Akhtar, M; Gupta, B K; Nigam, M; Banerjee, A; Satsangi, D K; Gondal, R; Arora, R; Sethi, K KThirteen patients with ruptured sinus of Valsalva aneurysm have been operated over a 3-1/2 year period. Right coronary sinus was predominantly involved and right ventricle was the most common site of rupture. Early surgery was performed in all cases. Both aorta and chamber of entry were explored for effective repair. Main repair was always done in the chamber of rupture either with a patch or interrupted pledgeted sutures followed by assessment at either end. Subannular ventricular septal defects in three cases were closed with a common patch with additional fixation in the middle at the aortic annulus to prevent aortic leak into the left ventricle. Three patients needed aortic valve replacement for gross aortic incompetence. Postoperative echocardiographic study revealed uniformly excellent results with good aortic valve or prosthetic function. One patient developed fatal pulmonary embolism two weeks following surgery. All other surviving patients are doing well and are in NYHA class I. We recommend dual exposure and repair technique for the repair of ruptured sinus of Valsalva aneurysms for optimal results.Item Effect of hypothermia on digitalis toxicity: an experimental study.(1971-01-01) Akhtar, M; Chakravarti, R N; Sarkar, A K; Wahi, P LItem Electroanatomical mapping of cardiac arrhythmias: a new approach to catheter ablation.(1998-09-03) Saxena, A; Dhala, A A; Akhtar, M; Jazayeri, M; Blanck, Z; Deshpande, S; Rathod, S; Sra, J SItem Electrocardiographic changes at high attitude.(1983-01-01) Das, B K; Tewari, S C; Parashar, S K; Akhtar, M; Grover, D N; Ohri, V C; Dutta, S K; Chatterjee, J CItem Electrocardiographic changes under moderate hypoxia.(1979-11-01) Akhtar, M; Bandopadhaya, P; Chatterjee, P C; Krishnamurti, SItem Evaluation of ischaemic disease with patient activated ambulatory monitoring.(1978-05-01) Das, B K; Akhtar, M; Balasubramanian, V; Chatterji, J CItem Evaluation of palpitation, giddiness and syncopal attacks with Holter monitoring.(1980-05-01) Akhtar, M; Das, B K; Chatterji, J CItem Evaluation of prescribing patterns in diabetic and hypertensive patients in a South Delhi Hospital.(2014-05) Pandey, Vikas; Hoda, Ubedul; Aqil, M; Sharma, M; Akhtar, M; Khandelwal, R; Najmi, Abul KalamBackground: Drug utilization studies (DUS) defined by World Health Organization as the marketing, distribution, prescription and use of drugs in a society, considering its consequences, either medical, social, and economic. The increasing importance of DUS as a valuable investigation resource in pharmacoepidemiology has been linking it with other health related areas, such as public health, pharmacovigilance, pharmacoeconomics, and pharmacogenetics. Methods: The study was a prospective DUS carried out in medicine OPD of Indian Institute of Technology Hospital, New Delhi, India in which a total of 595 prescriptions of hypertensive and diabetic patients were reviewed. All diabetic and/or hypertensive patients; irrespective of age, gender; who had least one drug in the prescription were included. Data were collected by screening of physician’s prescribing record and patient medication profile. Results: A total of 595 prescriptions were recorded. 57.31% were males as compared to 42.69% females. 54.62% patients were hypertensive (325 prescription); 14.78% patients were diabetic (88 prescription) whilst 30.58% had both the diseases. Of 507 prescriptions having antihypertensive drugs, combination therapy was utilized (40.8%) in the prescriptions and out of 270 prescriptions having antidiabetic drugs, 143 (52.96%) prescription were of combination therapy. Among antihypertensive drugs, angiotensin-converting enzyme inhibitors were the most frequently prescribed class of drugs (19.18%). The combination most commonly prescribed was amlodipine and atenolol (14.05%). Antidiabetic drugs made up for 11.05% of the total drugs prescribed. 28.78% of all hypoglycemic agents were sulfonylurea. Glimepiride and metformin combination was the most prescribed anti-diabetic drugs combination (16.16%). Conclusion: Both hypertension and diabetes are considered to be lifestyle diseases. Hence, apart from optimal and appropriate prescribing, there is a need for lifestyle modification to obtain improved outcomes. Combination therapy was observed in a high percentage of prescriptions. Though monotherapy is associated with improved compliance and fewer side effects, combination therapy is desirable for synergistic actions and to overcome complications.Item Interesting echocardiogram.(1980-01-01) Parashar, S K; Das, B K; Akhtar, M; Sindhi, J C; Chatterji, J CItem Is locally advanced breast cancer a neglected disease.(2011-10) Akhtar, M; Akulwar, V; Gandhi, D; Chandak, KBackground and Aims: Breast cancer is the second most common malignancy in India, and majority of patients present as a locally advanced breast carcinoma (LABC). Evaluating the prevalence of LABC and assessing the causes of local advancement and delayed presentation is the aim of the present study. Settings and Design: This was a rural hospital-based prospective cross-sectional study. Statistical Analysis: Descriptive statistics. Materials and Methods: Seventy-one cytologically/histopathologically confirmed cases of breast carcinoma were enrolled in the study. Breast sarcomas and lymphoma were excluded and, of them, prevalence of LABC and causes of delay and local advancement, i.e. patient factors, system factors and biological factors, were evaluated. Results: LABC accounted for 50.7% of these patients. On assessing the cause of advancement of LABC, patient factor (69.8%) was the major cause for delayed presentation, followed by system delay (23.6%). Patient factors were lack of awareness of breast cancer (75%) and financial constraints (52.8%). The system factor was nonreferral by general practitioners to specialty centers or trying to treat these patients with other allied modalities of treatment. Conclusions: LABC in the Indian scenario is an outcome of neglect due to patient and system factors. These factors offer an excellent opportunity to plan a community-oriented preventive strategy for the general population and practitioners to decrease the incidence of LABC.Item Management strategies in patients at high risk of sudden cardiac death following myocardial infarction.(1995-03-01) Sra, J; Underwood, R D; Akhtar, MOver 50 percent of deaths in patients who survive an acute myocardial infarction (MI) are due to fatal ventricular tachyarrhythmias. Patients who survive an episode of sustained ventricular arrhythmia are at highest risk of recurrent cardiac arrest. Electrophysiological studies have been found to be useful in guiding therapy and reducing mortality in these patients. However, evaluation and treatment of nonsustained ventricular tachycardia following MI remains controversial. Asymptomatic patients at high risk after MI include those who have significant left ventricular dysfunction, positive late potentials on signal-averaged electrocardiogram (SAECG), high grade ventricular ectopy and abnormal heart rate variability. These tests, however, have a low positive predictive accuracy and are not helpful to guide therapy with antiarrhythmic drugs which are usually ineffective and can frequently harm these patients. Beta-adrenoreceptor blocking agents, however, have been shown to reduce mortality after an acute myocardial infarction.Item Master double two step exercise (DMT) with telemetry and submaximal treadmill exercise. A comparative study.(1980-05-01) Akhtar, M; Das, B K; Chatterji, J CItem Myocardial infarction in patients undergoing hyperbaric oxygen therapy.(1973-04-01) Krishnamurti, S; Akhtar, M; Krishnan, N RItem Our experiences of rehabilitation of ischaemic heart disease patients in the armed forces.(1979-10-01) Chatterji, J C; Das, B K; Akhtar, MItem Performance of seed germination and growth of Vicia faba L. in fly ash amended soil.(2003-01-17) Rai, U N; Gupta, D K; Akhtar, M; Pal, AmitThe performance of Vicia faba L. in soil amended by different concentrations of fly ash has been studied. The parameters considered are seed germination, growth behaviour and nodulation frequency of the plant. Results revealed that while fly-ash amendment to the soil improved the growth performance at initial stages with application of lower concentrations, it was inhibitory at higher exposure concentrations. Although there was no difference in survival rates, but the seedling growth was reduced in comparison to control plants. Fly ash delayed the nodulation as lesser number of nodules was recorded at higher amendments. Results suggested feasibility of growing V. faba in fly ash contaminated area.Item Polymyositis--a review and follow up study of 24 cases.(1993-06-01) Narayanaswamy, A S; Akhtar, M; Kumar, N; Lazar, A ITwenty-four cases of polymyositis, 3 (12.5%) of them Dermatomyositis, have been treated and followed up for over 12 years. Majority (75%) were males. Inflammatory lesion was the cause in 18 (75%), collagen disease in 4 (16.7%) and malignancy in 2 (8.35%). Presenting features were fever (100%), proximal muscle weakness (95.8%) and tenderness (54.2%), facial and respiratory muscle weakness (4.2%). Raised CPK and transaminases, electromyogram abnormality and positive muscle biopsy were recorded in all. All were treated with steroids. Complication/associations noted were arthalgia (25%), dysphagia (20.6%), peripheral neuritis (8.35%), diabetes mellitus (4.2%), pulmonary fibrosis (4.2%) and malabsorption (4.2%). Fourteen cases (58%), all of inflammatory aetiology, recovered completely. Seven cases (29.2%) developed permanent atrophy of affected muscles. Cases with collagen disease and malignancy fared worse and deteriorated because of the primary disease.