Browsing by Author "Agrawal, J K"
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Item Acrocephalosyndactyly--type I (Apert's syndrome).(1999-08-25) Singh, S K; Chaturvedi, R; Pal, S K; Singh, K K; Sinha, S K; Singh, S K; Agrawal, J KItem Adreno-cortical function in leprosy.(1988-10-01) Garg, R; Agrawal, J K; Bajpai, H S; Singh, G; Srivastava, P KAdreno cortical function was carried out in 43 cases of leprosy. These cases were further divided into tuberculoid, borderline, lepromatous and Lepra reaction. Serum and urinary electrolyte, urinary 17-Ketosteroid and 17-Ketogenic steroid and plasma cortisol levels were measured to assess the adrenocortical status in these different forms of leprosy. It was observed that these parameters were within normal limit in tuberculoid leprosy except low value of urinary 17-Ketogenic steroid. The borderline and Lepromatous leprosy cases revealed low values of urinary sodium, potassium and 17-Ketogenic steroid and high level of serum potassium. However, the cases of lepra reaction revealed low value of serum and urinary sodium and potassium, urinary 17-Ketogenic steroid. The basal plasma cortisol level was high in this group but it was statistically insignificant.Item Adrenocortical insufficiency in smear positive pulmonary tuberculosis.(1992-07-01) Matah, S C; Kesharwani, G L; Srivastava, G N; Singh, S K; Agrawal, J KWe studied 40 patients with pulmonary tuberculosis. All were positive for acid-fast bacilli (AFB) in the sputum. Their mean age was 30 yrs (range 10-50 yrs) and the duration of illness was 26.3 +/- 2.3 months. Radiologically minimal, moderately advanced and far advanced lesions were present in 7 (17.5%), 9 (22.5%) and 23 (57.5%) patients respectively. One patient with endobronchial lesion had no radiological evidence of pulmonary tuberculosis. Clinically, 14 patients (35%) had one or the other features of adrenocortical insufficiency. Postural hypotension was the commonest feature and was present in 11 patients (27.5%), followed by nausea and vomiting (20%), loss of axillary hair and libido (10%), skin and mucosal pigmentation in 7.5% of the cases. ACTH stimulation revealed incomplete adrenocortical insufficiency (partially responsive adrenal) in 5 patients (12.5%) and complete adrenocortical insufficiency (non-responsive adrenal) in 2 patients (5%). Patients with features of adrenal insufficiency had significantly longer duration of illness (p < 0.001) but there was no correlation with extent or type of lesion.Item Adrenoleukodystrophy presenting as Addison's disease in childhood.(2000-12-31) Singh, S K; Chaturvedi, R; Singh, S K; Agrawal, J KItem Allergy to human insulin.(1996-04-01) Singh, S K; Gera, N; Bandyopadhyaya, B; Sarkar, D; Agrawal, J KItem Artesunate therapy in falciparum malaria--alone or in combination.(1999-05-25) Singh, S K; Mandal, A K; Pal, S; Sinha, S K; Singh, K K; Chaturvedi, R; Singh, S K; Agrawal, J KItem Avoidance learning under hypo and hyperglycemia in rats.(1990-04-01) Agrawal, J K; Thombre, D PLearning behaviour under different glycaemic conditions were studied in albino rats using an avoidance box. When insulin and glucose levels were low after fasting, animals showed delay in avoidance learning. But there was no change in acquisition of learning after hypoglacaemia induced by insulin. This difference in behaviour under hypoglycaemia of almost similar severity is possibly due to difference in its rate of induction and activation of counter regulatory neuro-endocrine mechanisms. Diabetic (alloxan) rats failed to improve learning. Besides, hyperglycemia, other factors like metabolic disturbances, cytotoxic effects of alloxan may have inhibited learning in this group. Hypo or hyperglycemia disturb the function of neuronal substrates responsible for learning and memory.Item Cardiac dysrhythmia in diabetic autonomic neuropathy.(1985-09-01) Tandon, R; Bajpai, H S; Agrawal, J KItem Cell mediated immunity in liver diseases.(1979-04-01) Bajpai, H S; Sen, P C; Joseph, J K; Agrawal, J KItem Cerebral salt wasting syndrome in a patient with a pituitary adenoma.(2003-03-17) Singh, S K; Unnikrishnan, A G; Reddy, V S; Sahay, R K; Bhadada, S K; Agrawal, J KCerebral salt wasting syndrome (CSWS) is often an unrecognized cause of hyponatremia that occurs in the setting of intracranial lesions. It is important to differentiate CSWS from the syndrome of inappropriate ADH secretion, as this would alter the management of hyponatremia. We describe a case of CSWS that occurred in association with a non-functioning pituitary adenoma.Item Cherubism--a case report.(1986-07-01) Reddy, G C; Nalini, K; Gupta, S K; Agrawal, J K; Bajpai, H S; Dutta, S; Hatwal, A; Gupta, AItem Clinical and biochemical profiles of young diabetics in North-Eastern India.(2002-09-09) Jyotsna, V P; Singh, S K; Gopal, D; Unnikrishnan, A G; Agrawal, N K; Singh, S K; Dixit, V K; Agrawal, A K; Agrawal, J KOBJECTIVE: We compared the clinical and biochemical profiles of young diabetics in North Eastern India. METHODS: Seventy diabetics who were detected at less than 30 years of age were studied. Patients with ketoacidosis or ketonuria on insulin withdrawal were grouped as insulin dependent diabetes mellitus (IDDM), patients with history of chronic abdominal pain with or without exocrine pancreatic dysfunction who either on ultrasonography (USG) or endoscopic retrograde cholangiopancreaticoduodenography (ERCP) revealed pancreatic calcification and/or ductal dilatation were grouped as fibrocalculous pancreatic diabetes (FCPD), those having BMI < 19 kg/m2 with history or stigmata of childhood malnutrition and who were ketosis resistant were taken to be protein deficient diabetes mellitus (PDDM)/malnutrition modulated diabetes mellitus (MMDM) and those who neither had ketonuria nor history of chronic abdominal pain, malabsorption or stigmata of malnutrition were grouped as NIDDM of young (NIDDY). RESULTS: Amongst the young diabetics studied FCPD constituted 32.9%, IDDM 28.6%, MMDM 21.4% and NIDDY 17.11%. USG abnormalities were observed in 21 of the 23 patients of FCPD. Seven out of these showed pancreatic head calcification on X-ray while 14 showed pancreatic duct dilatation and calcification or calculi on USG. In the two remaining patients, ERCP revealed tortuousity of main pancreatic duct and calcification which were not detected on USG. Majority of FCPD and MMDM patients revealed insulin resistance on insulin tolerance test (ITT). HDL was significantly lower in NIDDY, while VLDL and triglycerides were significantly higher in FCPD and MMDM as compared to controls. Microvascular complications of diabetes were seen in all these groups, with peripheral neuropathy being more common in FCPD (43.5%) and background diabetic retinopathy in NIDDY (41%). CONCLUSIONS: We conclude that FCPD and MMDM together form majority (54.29%) of young diabetics at our center and a sizeable proportion of them may have microvascular complications, even at the time of diagnosis.Item Cranial irradiation--an unusual cause for diabetes insipidus.(2000-11-20) Jyotsna, V P; Singh, S K; Chaturvedi, R; Neogi, B; Bhadada, S K; Sahay, R K; Singh, S K; Agrawal, J KCentral diabetes insipidus frequently occurs due to tumours in the region of pituitary or hypothalamus or following surgical trauma to these regions. Rarely it has been reported following cranial irradiation. We report the case of a middle aged woman who underwent surgical removal of a frontal capillary hemangioblastoma and received cranial irradiation. She presented ten months later with features of diabetes insipidus which was confirmed to be of central origin. She responded well to desmopressin nasal spray. Radiation induced damage to the hypothalmo-pituitary axis presents usually with anterior pituitary hormone deficiencies, most commonly that of growth hormone. Presentation as central diabetes insipidus is very uncommon.Item Cystic fibrosis in one family.(1993-11-01) Kumar, S; Singh, S K; Agrawal, J KItem Diabetic retinopathy (a clinico-biochemical study).(1979-10-01) Bajpai, H S; Mehra, K S; Singh, V P; Tikko, S K; Agrawal, J K; Sharma, AItem Effect of fenfluramine on serum T3, T4 and TSH levels in obesity.(1992-05-01) Gupta, S S; Agrawal, J K; Bajpai, H S; Bhatt, R P; Singh, S KA prospective, randomised case-control trial of an anorectic drug, fenfluramine was conducted on 30 patients of simple obesity. The study revealed that the drug was well tolerated, non-toxic and effective in reducing the body weight and normalising the thyroid profile. Reduction in body weight, rise in serum thyroxine (T4) and fall in serum triiodothyronine (T3) was highly significant (p less than 0.01) in drug treated group as compared to controls (p less than 0.05) after 12 weeks of therapy. There was also fall in serum thyroid stimulating hormone (TSH) levels but without any statistical significance.Item Etiological profile of short stature.(2003-07-28) Bhadada, S K; Agrawal, N K; Singh, S K; Agrawal, J KOBJECTIVE: To study the frequency of various causes of short stature and their etiological contribution in a referral endocrinology and metabolism clinic at a tertiary care hospital. METHODS: 352 children with growth retardation attending endocrine clinic between Feb 1999 to Mar 2001 were investigated for etiology of short stature. Agrawal's growth chart was used for percentiles and height velocity. Various relevant radiological, biochemical and hormonal investigations were performed. RESULTS: Normal variant short stature was the most common cause of short stature followed by endocrine causes. CONCLUSION: In males most common cause of short stature was constitutional growth delay, while in females most common cause of short stature was familial short stature.Item Fibrocalculous pancreatic diabetes and macrovascular disease.(2001-11-01) Unnikrishanan, A G; Sahay, R K; Bhadada, S K; Agrawal, N K; Singh, S K; Agrawal, J KItem Gliclazide in the treatment of obese NIDDM patients.(1994-02-01) Kumar, S; Keswani, P; Bose, B S; Agrawal, J KItem Glucose tolerance test in leprosy.(1990-01-01) Garg, R; Agrawal, J K; Bajpai, H S; Singh, G; Srivastava, P KGlucose tolerance test was carried out in 43 cases of leprosy. They included cases of tuberculoid, borderline, lepromatous leprosy and those with lepra reaction. It was observed that normal curve was common in tuberculoid leprosy. Flat glucose tolerance curve was observed in borderline and lepromatous leprosy. However, the diabetic curve was common in Lepra reaction. Fasting blood sugar was low in lepromatous leprosy and it tended to be marginally high in lepra reaction. Normal GTT response was observed in those with duration of disease between 0-6 months, flat curves in those with duration of disease between 7-12 months while diabetic curve was more common in those with disease duration of more than 2 years.
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