Browsing by Author "Agarwal, Mahavir Prasad"

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    Assessment of Biochemical and Hematological Changes in Pregnant Malaria Patients and Pregnant Non-Malaria Women: A Comparative Study
    (Society for Health Care & Research Development, 2018-09) Agarwal, Anjali; Agarwal, Mahavir Prasad
    Background:During state of pregnancy females are highly susceptible to infection which gravely affect both maternal and foetal outcome. At present, diagnosis of malarial parasite is basically by microscopic counting of the amount of parasites present in the red blood cells of the suspected patients. Therefore, the aim of the present study was to determine the alterations in hematological and biochemical parameters in pregnant individuals with malaria and pregnant subjects without malaria. Methods: The present prospective study was conducted in Department of Obstetrics & Gynecology, District Hospital, Dhoulpur, Rajasthan, India. All the subjects with typhoid were ruled out using widal test. Subjects with no evidence of parasite on smear examination were excluded from the study. All the subjects were given a predesigned questionnaire to obtain information about the demographics, age and residential status. Anticubital vein was used to withdraw blood samples in completely sterile manner. All the data was arranged in a tabulated form and expressed as mean +/- Standard deviation. Unpaired student t test was used as a test of significance. Result:The study enrolled a total of 50 subjects, of which 25 had malaria and 25 were controls. The mean transferrin level in Group I and Group II was 3.23 ± 0.55 and 4.62 ± 0.55. There was a significant difference between the two groups. Total serum cholesterol and triglycerides level showed a significant difference between the two groups. Conclusion: In our study, serum iron level, transferrin level and triglyceride and cholesterol showed a significant difference between the two groups.
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    Assessment of Maternal Hematological and Biochemical Parameters in Pregnancy Outcome: A Clinical Study
    (Ibn Sina Academy of Medieval Medicine & Sciences, 2018-07) Agarwal, Anjali; Agarwal, Mahavir Prasad
    Background: Medical conditions like eclampsia, hemorrhage- ante or post-partum have increased the occurrence of maternal deaths.  Pre-eclampsia can cause potentially lethal events like abruption of placenta, DIC, hemorrhage, liver failure, kidney failure and cardiovascular failure.  Therefore, the present study was aimed to estimate the effect of maternal Hematological and Biochemical Parameters in Pregnancy Outcome. Methods: The study consisted of all the pregnant females reporting to the hospital during a duration of 2 years.  The females with systolic pressure above 140 mmHg and diastolic pressure above 90 mm Hg were regarded as hypertensive and included in the study. All the required hematological and biochemical markers like AST, ALT, hemoglobin, PCV, Uric acid, MCV and red blood cell, prothrombin time and platelet counts were evaluated. A follow up of all the subjects were maintained during the entire pregnancy duration and outcome was noted. All the data obtained was arranged in a tabulated form and analyzed using SPSS software. Student t test was used for analysis and probability value of less than 0.05 was considered as significant. Results: The mean age of the subjects was 29.34+/-3.20 years. The mean hemoglobin level amongst subjects who died was 12.55 +/-1.67 and amongst the Live subjects was 13.44 +/-1.82. The mean ALT level amongst subjects who died was 163.76±342.7 and amongst the Live subjects was 45.47±55.23. There was a significant difference between them. The mean AST was 324.68±800.18 amongst dead mothers and 50.43±143.17 amongst live mothers. Conclusion: From the above study it can be concluded that biochemical parameters act as valuable predictors of pregnancy outcome. AST, ALT and uric acid levels were significantly different amongst both the groups.