Browsing by Author "Abdul, Rohman"

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    Antioxidant activity, total phenolic and flavonoid contents of selected medicinal plants used for liver diseases and its classification with chemometrics
    (Open Science Publishers LLP, 2019-06) Widodo, Harto; Sismindari, Sismindari; Widya, Asmara; Abdul, Rohman
    Liver disease has become one of the major health problems in the world, and the death rate is going rapidly toincrease. Oxidative stress plays a crucial role in the emerging, development, and the progression of liver diseases.Ethnobotanical research has an undoubted profound impact on the development of numerous new drugs. The aimof this research, therefore, was to examine the antioxidant activities of 14 selected plants used for treating liverdiseases by traditional healers of Indonesia ethnicities and to classify these plants using chemometrics of principalcomponent analysis (PCA). The extraction using methanol as the solvent was performed with two stages maceration.Total phenolic and flavonoid compounds were determined by Folin–Ciocalteau and AlCl3 method, respectively,whereas antioxidant activity was estimated using 2,2′-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging,trolox equivalent antioxidant capacity (TEAC), and ferric reducing antioxidant power (FRAP) assay. Among 19methanol extracts of 14 plants, the leaves of Baccaurea racemosa, Macaranga subpeltata, and Piper sp. showed thehighest antioxidant properties. The phenolic content correlated with TEAC, FRAP, and DPPH radical scavengingactivity, while flavonoid did not significantly affect these antioxidant activity methods. PCA successfully classifiedthe plant samples using the variables of antioxidant activities and phenolic-flavonoid contents. The selected plantshave promising antioxidant properties which support their utilization for either liver diseases medication or oxidativestress-related diseases prevention
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    Application of near- and mid-infrared spectroscopy combined with chemometrics for discrimination and authentication of herbal products: A review
    (Open Science Publishers LLP, 2019-04) Abdul, Rohman; Windarsih, Anjar; Hossain, M A. Motalib; Mohd, Rafie Johan; Ali, Md. Eaqub; Nurrulhidayah, Ahmad Fadzilah
    Herbal medicines along with its preparations have been commonly used as preventive and promotive agents around theworld, especially in developing countries. Motivated by economic profits, the high-priced value of herbal medicinesmay be substituted or adulterated with less expensive ones; therefore, the authentication methods must be developedto overcome the adulteration practices. Due to their properties as fingerprint analytical techniques, near-infrared (NIR)and mid-infrared (MIR) spectroscopies offered fast and reliable techniques for authentication of herbal medicine.The data generated during authentication of herbal medicines were complex and difficult to be interpreted; therefore,the statistical approach called chemometrics has been used to treat data. The objective of the present review was tohighlight the updates on the application of NIR and MIR spectroscopies and chemometrics techniques (discrimination,classification, and quantification) for discrimination and authentication of herbal medicine.
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    Application of response surface methodology as mathematical and statistical tools in natural product research
    (Open Science Publishers LLP, 2019-10) Florentinus, Dika Octa Riswanto; Abdul, Rohman; Suwidjiyo, Pramono; Sudibyo, Martono
    Response Surface Methodology (RSM) models combined with experimental designs became popular in recentyears. Their advantages to analyze the interactive effects among different factors and the efficiency considerationsencouraged more researchers to conduct natural product research employed with these models. A review about basicprinciples of factorial designs, central composite designs, Box–Behnken designs, and Doehlert designs which utilizedalong with the RSM and their applications in natural product research is presented. The objective of this reviewwas to report various experimental design techniques and their applications in the field of natural product research.Furthermore, the characteristic of each design is also presented and the trends of RSM applications in natural productresearch are also discussed in this paper.
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    Chemical composition and antioxidant studies of underutilized part of mangosteen (Garcinia mangostana L.) fruit
    (Open Science Publishers LLP, 2019-08) Abdul, Rohman; Rafi, Mohamad; Alam, Gemini; Muchtaridi, Muchtaridi; Windarsih, Anjar
    Mangosteen (Garcinia mangostana L) is one of Indonesian fruit with export commodity due to its sweet-sour andpleasant taste. The pulp of this fruit is frequently consumed freshly, while the seed and peel are removed and become awaste. The chemical components contained in mangosteen’s seed and peel, especially xanthones, have been reported asantioxidants either in vitro or in vivo. Several traditional medicine products used the extracts of mangosteen as one ofits components; therefore, the characterization of mangosteen extracts through identification of its active componentsis very important. This review article highlighted the updates on the characterization and antioxidant activities ofmangosteen’s seed and peel to prove that the wastes of mangosteen fruit could be advantageous to be developed asfunctional food as antioxidants. Several databases have been used during performing this review, including PubMed,Scopus, Biological abstracts, chemical abstracts, and Google Scholar.
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    Ethnomedical uses of Cananga odorata (Lam.) Hook. f. and Thomson in indigenous traditional medicine among Indonesia ethnic groups
    (Open Science Publishers LLP, 2024-09) Nuning, Rahmawati; Ika, Yanti M Sholikhah; Rohmat, Mujahid; Yuli, Widiyastuti; Agung, Endro Nugroho; Abdul, Rohman
    Cananga odorata, commonly known as ylang-ylang, is an evergreen perennial tropical tree belonging to the Annonaceae family, which is traditionally and scientifically reported to have various pharmacological activities. This indigenous medicine study was carried out to document the traditional usage of C. odorata for medicinal reasons by Indonesian ethnic groups. This is one of numerous initiatives aimed at preserving indigenous knowledge and medical practices maintained by the community. Data were acquired during 2015 and 2017 through in-depth interviews with selected traditional healers from each ethnic group throughout 34 Indonesian provinces, who were chosen using a purposive sampling approach based on inclusion criteria. The information gathered includes the demographic data of healers, medicinal plants used, potions, and their applications for health purposes. Following the completion of the interview with the informant, specimens of medicinal plants were collected. Data quantification was accomplished by examining the value of plant parts and doing a simple ranking analysis for multihealth purposes. This study revealed 42 traditional applications of C. odorata by 36 traditional healers from 28 ethnic groups in 16 provinces to overcome 18 diseases. Cananga odorata was primarily obtained from the woodland instead of the house garden and other environments. Skin disease was identified as the most prevalent indication of C. odorata, in agreement with the most commonly employed administration method, the external route. Leaves became the foremost prominent plant part utilized by healers. This study emphasized the significant role of traditional healers in healing various illnesses with C. odorata and the variations in C. odorata ethnomedical usage as a traditional remedy in Indonesia. Nonetheless, cultivating initiatives should be started as more than 60% of identified C. odorata has yet to be grown. The study’s findings are likely to benefit various stakeholders, serve as baseline data for further studies on the efficacy and safety of C. odorata, and contribute to efforts for developing health products that employ C. odorata.