Vajira Medical Journal
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Browsing Vajira Medical Journal by Author "Angkana Pongpatiroj"
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Item Effects of Hormone Replacement Therapy on the Quality of Life in Postmenopausal Women(Vajira Medical Journal, 2010-03-29) Angkana Pongpatiroj; Manit Sripramote; Grit WanitwanathongAbstract Effects of Hormone Replacement Therapy on the Quality of Life in Postmenopausal Women Angkana Pongpatiroj MD Manit Sripramote MD Grit Wanitwanathong MD Department of Obstetrics and Gynecology, BMA Medical College and Vajira Hospital Objective: To evaluate effects of hormone replacement therapy on the quality of life in postmenopausal women. Study design: Longitudinal descriptive study. Setting: The menopausal clinic, Department of Obstetrics and Gynecology, BMA Medical College and Vajira Hospital Subjects: Postmenopausal women attending the menopausal clinic from June, 1999 to May, 2000. Methods: Quality of life of postmenopausal woman were measured by questionnaire before receiving hormone replacement therapy. Quality of life postmenopausal women who completely received 3 months hormone replacement therapy were re-measured. The scale contains four domains: vasomotor, psychosocial, physical and sexual domains. For analysis, the item scores were converted to the score ranging from 1 to 8; score 1 rated as the subject did not experience the problems and score 8 rated as extremely bothered. The mean quality of life scores of pre and post hormone replacement therapy were compared by statistical analysis paired t-test or Wilcoxon signed ranks test). Main outcome measures: Quality of life measured by the menopause-specific quality of life questionnaire (MENQOL questionnaire) that translated to Thai. Quality of life scores comprise four domains: vasomotor, psychosocial, physical and sexual domains. Results: The 36 of 45 cases were completely received 3 months hormone replacement therapy and answered the questionnaires. Improvement of quality of life scores in all domains was observed in postmenopausal women who completely received 3 months hormone replacement therapy, In the vasomotor domain, scores improved from 3.57 to 1.56, psychosocial domain scores improved from 3.49 to 2.38, physical domain scores improved from 3.81 to 2.54 and sexual domain scores improved from 4.35 to 2.38. There were statistically significant differences in all domains (p-value \< 0.05). Conclusion: Improvement of quality of life in all domains measured by questionnaire was observed in postmenopausal women who completely received 3 months hormone replacement therapy. Key words: hormone replacement therapy, quality of life, postmenopausal women Vajira Med J 2001 ; 45 : 1 - 11Item Mammographic Density Changes of Postmenopasual Women after Hormonal Replacement Therapy with Cyclic and Continuous Combined Regimens(Vajira Medical Journal, 2010-03-29) Shaleewan Seukwattana; Angkana Pongpatiroj; Okas Thaipisuttikul; Sirirat TeawiratAbstract Mammographic Density Changes of Postmenopasual Women after Hormonal Replacement Therapy with Cyclic and Continuous Combined Regimens Shaleewan Seukwattana MD* Angkana Pongpatiroj MD* Okas Thaipisuttikul MD* Sirirat Teawirat MD** *Department of Obstetrics and Gynecology, BMA Medical College and Vajira Hospital **Department of Rediology, BMA Medical College and Vajira Hospital Objective: To compare mammographic density changes of postmenopausal women who received hormonal replacement therapy with cyclic and continuous combined regimens. Study design: Retrospective cohort study. Setting: Menopausal clinic, Department of Obstetrics and Gynecology, BMA Medical College and Vajira Hospital. Subjects: The 62 postmenopausal women attending at menopausal clinic who received hormonal replacement therapy with cyclic or continuous combined regimens for at least one year, 31 in each group. Methods: The medical records and mammograms of postmenopausal women who received hormonal replacement therapy with cyclic or continuous combined regimens were reviewed. Mammograms before and one year after hormonal replacement therapy were interpreted by one radiologist using Wolf's criteria. Main outcome measures: Mammographic density changes before and at least one year after hormonal replacement therapy following Wolf's criteria. Results: Mammographic densities after receiving hormonal replacement therapy were increased in both groups. Numbers of women with increase in mammographic density in continuous combined group (25/31, 80.6%) were higher than in cyclic combined group (6/31, 19.4%), the difference was statistically significant (p