Antioxidant mediated defensive potency of Caesalpinia bonducella nut on Acetaminophen-inebriated spleen and cardiotoxicity: Implications on oxidative stress and tissue morphology in an In vivo model

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dc.contributor.authorNithiyanandam, Sangeethaen_US
dc.contributor.authorJaisankar, Vaishnavien_US
dc.contributor.authorParthasarathy, Manishaen_US
dc.contributor.authorKatturajan, Ramkumaren_US
dc.contributor.authorEvan Prince, Sabinaen_US
dc.date.accessioned2023-08-09T06:03:09Z
dc.date.available2023-08-09T06:03:09Z
dc.date.issued2023-04
dc.description.abstractOverdosing on medications can be unintentional or deliberate. Acetaminophen (APAP) is a widely used over-the-counter analgesic and antipyretic drug. APAP overdose can induce spleen and cardiotoxicity apart from hepatotoxicity. Bonduc nut is well-known for its medicinal and therapeutic properties. More scientific data is necessary to be therapeutically relevant. This study examined the effects of Bonduc nut extract (BNE) on APAP-induced spleen and cardiotoxicity in Wistar albino rats. The rats were divided into five groups of six rats each. In vitro assays were carried out to analyze antioxidant activity and free radical scavenging activity in aqueous, ethanol, and methanol solvents in Bonduc nut powder. Total phenolic content, DPPH, catalase, and peroxidase activity were used to test antioxidant activity. The rats were euthanized after the study period to examine antioxidant parameters such as superoxide dismutase, catalase, reduced glutathione, and glutathione peroxidase, as well as lipid peroxidation and histopathology of the spleen and heart tissues. Results suggest that compared to other solvents aqueous has better Invitro antioxidant ability and the same extract significantly increased the antioxidant and reduced lipid peroxidation followed by restoring the tissue morphology in APAP-induced spleen and cardiotoxicity. The outcome of the study revealed that aqueous BNE has a significant protective efficacy against APAP-induced spleen and cardiotoxicity in Wistar albino rats.en_US
dc.identifier.affiliationsSchool of Bio Sciences and Technology, Vellore Institute of Technology, Vellore, Tamil Nadu, Indiaen_US
dc.identifier.citationNithiyanandam Sangeetha, Jaisankar Vaishnavi, Parthasarathy Manisha, Katturajan Ramkumar, Evan Prince Sabina. Antioxidant mediated defensive potency of Caesalpinia bonducella nut on Acetaminophen-inebriated spleen and cardiotoxicity: Implications on oxidative stress and tissue morphology in an In vivo model. Indian Journal of Biochemistry & Biophysics. 2023 Apr; 60(4): 297-306en_US
dc.identifier.issn0019-5189
dc.identifier.issn0975-1009
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/221640
dc.languageenen_US
dc.publisherCSIR-NIScPRen_US
dc.relation.issuenumber4en_US
dc.relation.volume60en_US
dc.source.urihttps://doi.org/10.56042/ijbb.v60i4.72352en_US
dc.subjectAntioxidantsen_US
dc.subjectAPAPen_US
dc.subjectBonduc nuten_US
dc.subjectCardiotoxicityen_US
dc.subjectFree radical scavengingen_US
dc.subjectSpleen injuryen_US
dc.titleAntioxidant mediated defensive potency of Caesalpinia bonducella nut on Acetaminophen-inebriated spleen and cardiotoxicity: Implications on oxidative stress and tissue morphology in an In vivo modelen_US
dc.typeJournal Articleen_US
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