Validity of 3-Tesla diffusion-weighted magnetic resonance imaging for distinction of reactive and metastatic lymph nodes in head-and-neck carcinoma

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dc.contributor.authorK, Vijayalakshmien_US
dc.contributor.authorPH, Raghuramen_US
dc.contributor.authorK, Saravananen_US
dc.contributor.authorCL, Krithikaen_US
dc.contributor.authorA, Kannanen_US
dc.date.accessioned2020-11-18T10:08:22Z
dc.date.available2020-11-18T10:08:22Z
dc.date.issued2020-07
dc.description.abstractObjectives: The objective was to study the relationship of 3-Tesla (3T) diffusion-weighted magnetic resonance imaging (DW-MRI) with apparent diffusion coefficient (ADC) value for distinction of reactive and metastatic lymph nodes (LNs) in head-and-neck carcinoma (HNC) patients and to determine the ADC cutoff value for metastatic LNs at various levels. Materials and Methods: 3T DW and T1- and T2-weighted imaging sequences were done in 34 patients with biopsy-proven primary HNC of 100 cervical LNs ≥1 cm in diameter. The mean ADC values were compared with histopathologically proven LNs using the independent t-test. ADC cutoff value was evaluated with sensitivity, specificity, accuracy, positive predictive value, negative predictive value and a receiver operating characteristic curve analysis. Results: The mean ADC value of reactive LN was 1.2933 × 10-3 mm2/s and metastatic LN was 0.908 × 10-3 mm2/s. An ADC cutoff value was 0.868 × 10-3 mm2/s with 84% sensitivity, 96% specificity, 93% accuracy, 87.5% positive predictive value, and 94.7% negative predictive value. A significant difference in mean ADC value between reactive and metastatic LNs was noted (P< 0.001). Conclusion: 3T DW-MRI is useful in differentiating reactive and metastatic cervical LNs in HNC patients. However, studies with larger sample size have to be performed to validate ADC threshold value with 3T DW-MRI in differentiating between reactive and metastatic LNs for clinical practiceen_US
dc.identifier.affiliationsDepartment of Oral Medicine and Radiology, SRM Dental College, Chennai, Tamil Nadu, Indiaen_US
dc.identifier.affiliationsDepartment of Oral Medicine and Radiology, SRM Dental College, Chennai, Tamil Nadu, Indiaen_US
dc.identifier.affiliationsDepartment of Radio Diagnosis, Sri Balaji Medical College and Hospital, Chennai, Tamil Nadu, Indiaen_US
dc.identifier.affiliationsDepartment of Oral Medicine and Radiology, SRM Dental College, Chennai, Tamil Nadu, Indiaen_US
dc.identifier.affiliationsDepartment of Oral Medicine and Radiology, SRM Dental College, Chennai, Tamil Nadu, Indiaen_US
dc.identifier.citationK Vijayalakshmi, PH Raghuram, K Saravanan, CL Krithika, A Kannan. Validity of 3-Tesla diffusion-weighted magnetic resonance imaging for distinction of reactive and metastatic lymph nodes in head-and-neck carcinoma. Journal of Cancer Research and Therapeutics. 2020 Jul; 16(3): 587-593en_US
dc.identifier.issn0973-1482
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/213864
dc.languageenen_US
dc.publisherWolters Kluwer India Pvt. Ltd.en_US
dc.relation.issuenumber3en_US
dc.relation.volume16en_US
dc.source.urihttps://dx.doi.org//10.4103/jcrt.JCRT_55_19en_US
dc.subjectApparent diffusion coefficient valuesen_US
dc.subjectcervical nodesen_US
dc.subjectdiffusion magnetic resonance imagingen_US
dc.subjecthead-and-neck neoplasmsen_US
dc.titleValidity of 3-Tesla diffusion-weighted magnetic resonance imaging for distinction of reactive and metastatic lymph nodes in head-and-neck carcinomaen_US
dc.typeJournal Articleen_US
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