Differential binding properties of Gal/GalNAc specific lectins available for characterization of glycoreceptors.

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dc.contributor.authorWu, A Men_US
dc.contributor.authorSong, S Cen_US
dc.contributor.authorSugii, Sen_US
dc.contributor.authorHerp, Aen_US
dc.date.accessioned1997-02-01en_US
dc.date.accessioned2009-05-27T09:07:39Z
dc.date.available1997-02-01en_US
dc.date.available2009-05-27T09:07:39Z
dc.date.issued1997-02-01en_US
dc.description84 references.en_US
dc.description.abstractDifferentiating the binding properties of applied lectins should facilitate the selection of lectins for characterization of glycoreceptors on the cell surface. Based on the binding specificities studied by inhibition assays of lectin-glycan interactions, over twenty Gal and/or GalNAc specific lectins have been divided into eight groups according to their specificity for structural units (lectin determinants), which are the disaccharide as all or part of the determinants and of GalNAc alpha 1-->Ser (Thr) of the peptide chain. A scheme of codes for lectin determinants is illustrated as follows: (1) F (GalNAc alpha 1-->3GalNAc), Forssman specific disaccharide--Dolichos biflorus (DBL), Helix pomatia (HPL) and Wistaria floribunda (WFL) lectins. (2) A (GalNAc alpha 1-->3 Gal), blood group A specific disaccharide--Codium fragile subspecies tomentosoides (CFT), Soy bean (SBL), Vicia villosa-A4 (VVL-A4), and Wistaria floribunda (WFL) lectins. (3) Tn (GalNAc alpha 1-->Ser (Thr) of the protein core)--Vicia villosa B4 (VVL-B4), Salvia sclarea (SSL), Maclura pomifera (MPL), Bauhinia purpurea alba (BPL) and Artocarpus integrifolia (Jacalin, AIL). (4) T (Gal beta 1-->3GalNAc), the mucin type sugar sequences on the human erythrocyte membrane(T alpha), T antigen or the disaccharides at the terminal nonreducing end of gangliosides (T beta)--Peanut (PNA), Bauhinia purpurea alba (BPL), Maclura pomifera (MPL), Sophora japonica (SJL), Artocarpus lakoocha (Artocarpin) lectins and Abrus precatorius agglutinin (APA).(5) I and II (Gal beta 1-->3(4)GlcNAc)--the disaccharide residue at the nonreducing end of the carbohydrate chains derived from either N- or O-glycosidic linkage--Ricinus communis agglutinin (RCA1), Datura stramonium (TAL, Thorn apple), Erythrina cristagalli (ECL, Coral tree), and Geodia cydonium (GCL). (6) B (Gal alpha 1-->3Gal), human blood group B specific disaccharide--Griffonia(Banderiaea) simplicifolia B4 (GSI-B4). (7) E (Gal alpha 1-->4Gal), receptors for pathogenic E. coli agglutinin, Shiga toxin and Mistletoe toxic lectin-I (ML-I) and abrin-a.en_US
dc.description.affiliationGlyco-immunochemistry Lab, Chang-Gung Medical College, Kwei-san, Tao-yuan, Taiwan.en_US
dc.identifier.citationWu AM, Song SC, Sugii S, Herp A. Differential binding properties of Gal/GalNAc specific lectins available for characterization of glycoreceptors. Indian Journal of Biochemistry & Biophysics. 1997 Feb-Apr; 34(1-2): 61-71en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/26535
dc.language.isoengen_US
dc.source.urihttps://https://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijbb/ijbb0.aspen_US
dc.subject.meshAcetylgalactosamine --metabolismen_US
dc.subject.meshBinding Sitesen_US
dc.subject.meshCarbohydrate Sequenceen_US
dc.subject.meshGalactose --metabolismen_US
dc.subject.meshHumansen_US
dc.subject.meshLectins --metabolismen_US
dc.subject.meshMolecular Sequence Dataen_US
dc.subject.meshOligosaccharides --chemistryen_US
dc.subject.meshReceptors, Mitogen --metabolismen_US
dc.titleDifferential binding properties of Gal/GalNAc specific lectins available for characterization of glycoreceptors.en_US
dc.typeComparative Studyen_US
dc.typeIn Vitroen_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
dc.typeReviewen_US
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