Evaluation Of Mutagenic And Antimutagenic Activity Of Methanol Extract Of Cousinia Thomsonii Against Cyclophosphamide

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dc.contributor.authorKhan, I. S.en_US
dc.contributor.authorBashir, K.en_US
dc.contributor.authorGulzar, N.en_US
dc.contributor.authorBhat, Y. M.en_US
dc.date.accessioned2020-10-16T07:51:25Z
dc.date.available2020-10-16T07:51:25Z
dc.date.issued2020-01
dc.description.abstractThe present study was conducted to evaluate the mutagenic and antimutagenic potential of Cousinia thomsonii (CT) extract in bone marrow cells of male wistar rats using some important parameters like micronucleated polychromatic erythrocyte (MnPCE), mitotic index (MI), chromosomal aberrations (CA) and polychromatic erythrocyte to normochromatic erythrocyte ratio (PCE/NCE). 30 male rats of wistar strain were divided into 6 groups with 5 rats each group. Group 1 rats were taken as negative control having free access to distilled water and rat feed. Group 2 rats were taken as positive control treated with mutagen cyclophosphamide (CP) at dose of 60 mg/kg b wt. for 2 days. Group 3 and 4 were treated with CT extract at dose of 100 and 200 mg/kg b wt. for 20 days. Group 5 and 6 were treated with 100 and 200 mg/kg b wt of CT extract for first 18 days and for last 2 days with CP at dose concentration of 60 mg/kg. It was found that rats treated with CT extract alone did not produce any significant changes in MnPCE, PCE/NCE ratio, CA and MI when compared with control treated rats (group 1). However in group 5 and 6 rats treated with CT extract in combination with CP a protective effect was observed against the cyclophosphamide induced cellular mutagenicity. In concluding remark Cousinia thomsonii was found to show antigenotoxic potential and also produce protective antimutagenic effects against CP induced chromosomal damage.en_US
dc.identifier.affiliationsCytogenetics and Molecular Biology Research Laboratory, University of Kashmir, Srinagar-190006, Jammu and Kashmir, Indiaen_US
dc.identifier.affiliationsDepartment of Clinical Biochemistry, University of Kashmir, Srinagar-190006, Jammu and Kashmir, Indiaen_US
dc.identifier.affiliationsCytogenetics and Molecular Biology Research Laboratory, University of Kashmir, Srinagar-190006, Jammu and Kashmir, Indiaen_US
dc.identifier.affiliationsDepartment of Botany, University of Kashmir, Srinagar-190006, Jammu and Kashmir, Indiaen_US
dc.identifier.citationKhan I. S., Bashir K., Gulzar N., Bhat Y. M.. Evaluation Of Mutagenic And Antimutagenic Activity Of Methanol Extract Of Cousinia Thomsonii Against Cyclophosphamide. International Journal of Pharmaceutical Sciences and Drug Research. 2020 Jan; 12(1): 53-57en_US
dc.identifier.issn0975-248X
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/206342
dc.languageenen_US
dc.publisherMRI Publication Pvt. Ltd.en_US
dc.relation.issuenumber1en_US
dc.relation.volume12en_US
dc.source.urihttps://doi.org/10.25004/IJPSDR.2020.120109en_US
dc.subjectCousinia thomsoniien_US
dc.subjectmicronucleusen_US
dc.subjectmitotic indexen_US
dc.subjectcyclophosphamideen_US
dc.titleEvaluation Of Mutagenic And Antimutagenic Activity Of Methanol Extract Of Cousinia Thomsonii Against Cyclophosphamideen_US
dc.typeJournal Articleen_US
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