The Impact Of Physicochemical Characteristics On Therapeutic Efficacy Of Anticancer Nanomaterials: A Review

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dc.contributor.authorSied Filli, M.en_US
dc.contributor.authorIbrahim, A. A.en_US
dc.contributor.authorAquib, M.en_US
dc.contributor.authorAbbas, A. B.en_US
dc.contributor.authorMorshed, A.en_US
dc.contributor.authorBoakye-yiadom, K. O.en_US
dc.contributor.authorKesse, S.en_US
dc.contributor.authorFarooq, M. A.en_US
dc.contributor.authorBazezy, M.en_US
dc.contributor.authorWang, Ben_US
dc.date.accessioned2020-10-16T07:49:50Z
dc.date.available2020-10-16T07:49:50Z
dc.date.issued2019-03
dc.description.abstractCancer is a global leading cause of death which suffers from treatment failures mainly due to intensive toxicity and lack of effectiveness of conventional drugs. The application of nanotechnology in cancer treatment promises to overcome the limitations of conventional drugs/drug delivery systems and improve their therapeutic efficacy. Materials at the nano scale possess novel properties that have an impact on their biological behaviour. The physiological interactions of nanomedicines in the body, which differ from those of conventional medicines, may provide benefits in pharmaceutical and/or clinical applications including, improvements in solubility, stability, efficacy, reduction of side effects, prevention and treatment of diseases. This paper discusses the unique characteristics and distinguished advantages of nanomaterials as anticancer drug carriers. Physicochemical properties of nanomaterials are critical parameters to their clinical translation. Hence, the impact of the main physicochemical properties on the efficacy of anitcancer nanomaterials, which are found to effective for cancer treatment and/or diagnosis, are presented. It is important to have reliable and robust characterization techniques that could enable relate physicochemical properties of nanomaterials with their in vivo behaviour. Brief explanation of the different techniques that can be used for studying the different physicochemical characteristics of nanomaterials is given. An important consideration, to achieve fast and successful development of nanotechnology-based anticancer drug products, is assessment and optimization of physicochemical and biopharmaceutical properties at the early stage. Obviously this requires collaboration among the different discovery and development scientists.en_US
dc.identifier.affiliationsSchool of Pharmacy, Department of Pharmaceutics, China Pharmaceutical University, Nanjing 211198, Chinaen_US
dc.identifier.affiliationsSchool of Medicine, Department of Infectious Diseases, Xuzhou Medical University, Xuzhou 221004 Chinaen_US
dc.identifier.affiliationsSchool of Pharmacy, Department of Pharmaceutics, China Pharmaceutical University, Nanjing 211198, Chinaen_US
dc.identifier.affiliationsEngineering Research Centre of Synthetic Polypeptide Drug Discovery and Evaluation, China Pharmaceutical University, Nanjing 210009, Chinaen_US
dc.identifier.affiliationsEngineering Research Centre of Synthetic Polypeptide Drug Discovery and Evaluation, China Pharmaceutical University, Nanjing 210009, Chinaen_US
dc.identifier.affiliationsSchool of Pharmacy, Department of Pharmaceutics, China Pharmaceutical University, Nanjing 211198, Chinaen_US
dc.identifier.affiliationsSchool of Pharmacy, Department of Pharmaceutics, China Pharmaceutical University, Nanjing 211198, Chinaen_US
dc.identifier.affiliationsSchool of Pharmacy, Department of Pharmaceutics, China Pharmaceutical University, Nanjing 211198, Chinaen_US
dc.identifier.affiliationsSchool of Pharmacy, Department of Pharmaceutics, China Pharmaceutical University, Nanjing 211198, Chinaen_US
dc.identifier.affiliationsSchool of Pharmacy, Department of Pharmaceutics, China Pharmaceutical University, Nanjing 211198, Chinaen_US
dc.identifier.citationSied Filli M., Ibrahim A. A., Aquib M., Abbas A. B., Morshed A., Boakye-yiadom K. O., Kesse S., Farooq M. A., Bazezy M., Wang B. The Impact Of Physicochemical Characteristics On Therapeutic Efficacy Of Anticancer Nanomaterials: A Review. International Journal of Pharmaceutical Sciences and Drug Research. 2019 Mar; 11(2): 61-70en_US
dc.identifier.issn0975-248X
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/206224
dc.languageenen_US
dc.publisherMRI Publication Pvt. Ltd.en_US
dc.relation.issuenumber2en_US
dc.relation.volume11en_US
dc.source.urihttps://doi.org/10.25004/IJPSDR.2019.110203en_US
dc.subjectNanothechnologyen_US
dc.subjectCanceren_US
dc.subjectPhysicochemical propertiesen_US
dc.subjectCharacterizationen_US
dc.subjectNanomaterialsen_US
dc.subjectTherapeutic efficacyen_US
dc.titleThe Impact Of Physicochemical Characteristics On Therapeutic Efficacy Of Anticancer Nanomaterials: A Reviewen_US
dc.typeJournal Articleen_US
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