Synthesis And Biological Evaluation Of Thiosemicarbazone Analogues Of Ornidazole As Antifungal Agents

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dc.contributor.authorKumar, N.en_US
dc.contributor.authorAggarwal, T.en_US
dc.contributor.authorSingh, G.en_US
dc.contributor.authorKumar, P.en_US
dc.contributor.authorKumar, R.en_US
dc.contributor.authorKaur, C.en_US
dc.date.accessioned2020-10-16T07:51:06Z
dc.date.available2020-10-16T07:51:06Z
dc.date.issued2020-01
dc.description.abstractTo synthesize a series of ornidazole thiosemicarbazone analogues on the basis of literature reviews of 2-Methyl-5-nitroimidazoles and thiosemicarbazones and to evaluate all the analogues in vitro for their activity against Aspergillus niger and fumigatus. Thiosemicarbazone analogues were synthesized from oxidising ornidazole with potassium dichromate and refluxing the oxidised product with substituted thiosemicarbazide using ethanol as solvent in the acidic medium overnight. All the synthesized analogues of ornidazole showed good antifungal action against fumigatus and niger except compound C-4. Unsubstituted amine analogue C-2 has shown highest percentage inhibition (96.6%, 500 μg/ml) against fumigatus while aromatic amine with or without electronegative atom analogues C-3 and C-5 has shown highest activity against Aspergillus niger which is two times than standard drug ornidazole (100%, 1000 μg/ml).en_US
dc.identifier.affiliationsInd-Swift Laboratories Limited, Bhagwanpur, Behra-140507, Punjab, Indiaen_US
dc.identifier.affiliationsLovely School of Pharmaceutical Sciences, Lovely Professional University, Phagwara-144401, Punjab, Indiaen_US
dc.identifier.affiliationsLovely School of Pharmaceutical Sciences, Lovely Professional University, Phagwara-144401, Punjab, Indiaen_US
dc.identifier.affiliationsIKG Punjab Technical University, Kapurthala-144603, Punjab, Indiaen_US
dc.identifier.affiliationsLovely School of Pharmaceutical Sciences, Lovely Professional University, Phagwara-144401, Punjab, Indiaen_US
dc.identifier.affiliationsDepartment of Pharmaceutical Chemistry, Khalsa College of Pharmacy, Amritsar-143001, Punjab, Indiaen_US
dc.identifier.citationKumar N., Aggarwal T., Singh G., Kumar P., Kumar R., Kaur C.. Synthesis And Biological Evaluation Of Thiosemicarbazone Analogues Of Ornidazole As Antifungal Agents. International Journal of Pharmaceutical Sciences and Drug Research. 2020 Jan; 12(1): 73-79en_US
dc.identifier.issn0975-248X
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/206290
dc.languageenen_US
dc.publisherMRI Publication Pvt. Ltd.en_US
dc.relation.issuenumber1en_US
dc.relation.volume12en_US
dc.source.urihttps://doi.org/10.25004/IJPSDR.2020.120112en_US
dc.subjectThiosemicarbazoneen_US
dc.subjectornidazoleen_US
dc.subjectantifungalen_US
dc.subjectAspergillus nigeren_US
dc.titleSynthesis And Biological Evaluation Of Thiosemicarbazone Analogues Of Ornidazole As Antifungal Agentsen_US
dc.typeJournal Articleen_US
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