Vascular endothelial growth factor insertion/deletion gene polymorphism in West Indian patients of type 2 diabetes and diabetic nephropathy.

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dc.contributor.authorDabhi, Brijesh
dc.contributor.authorMistry, Kinnari N
dc.contributor.authorPatel, Hitesh
dc.contributor.authorLal, Sanjay
dc.date.accessioned2015-06-23T09:52:00Z
dc.date.available2015-06-23T09:52:00Z
dc.date.issued2015-04
dc.description.abstractDiabetic nephropathy (DN) is a major cause of morbidity and mortality in diabetes. Vascular endothelial growth factor (VEGF) is a potent multi-functional cytokine which plays a key role in the pathogenesis of DN. In this study, we evaluated the possible association of the VEGF gene (I/D) polymorphisms with DN in type 2 diabetes patients in West Indian population. Genotyping (I/D) of the VEGF gene polymorphism was done by the polymerase chain reaction. A total of 103 patients with type 2 diabetes, 102 patients with DN, 108 patients with non-diabetic nephropathy and 143 healthy controls were genotyped. The frequency of VEGF genotype distribution and biochemical parameters like creatinine and HbA1c were compared in diabetic, diabetic nephropathy, non diabetic nephropathy and control groups. We found significant difference in creatinine level in DN and NDN groups on comparison with control group. Our study suggests that I/D polymorphism in the promoter region of the VEGF gene is not associated with DN in type 2 diabetes patients, but might have a role in development of non-diabetic nephropathy.en_US
dc.identifier.citationDabhi Brijesh, Mistry Kinnari N, Patel Hitesh, Lal Sanjay. Vascular endothelial growth factor insertion/deletion gene polymorphism in West Indian patients of type 2 diabetes and diabetic nephropathy. Indian Journal of Biochemistry & Biophysics. 2015 Apr; 52 (2): 209-212.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/158225
dc.language.isoenen_US
dc.publisherNISCAIR-CSIR, Indiaen_US
dc.source.urihttps://nopr.niscair.res.in/handle/123456789/31533en_US
dc.subjectDiabetic nephropathyen_US
dc.subjectPolymorphismen_US
dc.subjectGenotypingen_US
dc.subjectVEGF geneen_US
dc.subject.meshDiabetes Mellitus, Type 2 --epidemiology
dc.subject.meshDiabetes Mellitus, Type 2 --genetics
dc.subject.meshDiabetic Nephropathies --epidemiology
dc.subject.meshDiabetic Nephropathies --genetics
dc.subject.meshGene Deletion
dc.subject.meshGenotyping Techniques --methods
dc.subject.meshHumans
dc.subject.meshIndia
dc.subject.meshMutagenesis, Insertional --genetics
dc.subject.meshPolymorphism, Genetic --genetics
dc.subject.meshVascular Endothelial Growth Factor A --genetics
dc.titleVascular endothelial growth factor insertion/deletion gene polymorphism in West Indian patients of type 2 diabetes and diabetic nephropathy.en_US
dc.typeArticleen_US
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