Effect of chlorpromazine and gossypol on Ca(2+)-ATPase activity in the microsomal membranes of rat testes.

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dc.contributor.authorMazumder, Ben_US
dc.contributor.authorSikdar, Ren_US
dc.contributor.authorSen, P Cen_US
dc.date.accessioned1991-04-01en_US
dc.date.accessioned2009-05-27T09:06:55Z
dc.date.available1991-04-01en_US
dc.date.available2009-05-27T09:06:55Z
dc.date.issued1991-04-01en_US
dc.description.abstractThe microsomal membranes isolated from rat testes have been found to contain a Mg(2+)-dependent and a Mg(2+)-independent Ca(2+)-ATPase. The enzyme activities were inhibited by two contraceptive drugs--gossypol and chlorpromazine. The inhibition by the former was affected by the presence of ligand(s) and not the substrate in the incubation medium, whereas ligand(s)/substrate did not affect the inhibition by chlorpromazine. This may be explained from the fact that the binding of chlorpromazine and ligand(s)/substrate to the enzyme are independent of each other whereas in case of gossypol the ligand(s) compete with the drug at the binding site of the enzyme.en_US
dc.description.affiliationDepartment of Chemistry, Bose Institute, Calcutta.en_US
dc.identifier.citationMazumder B, Sikdar R, Sen PC. Effect of chlorpromazine and gossypol on Ca(2+)-ATPase activity in the microsomal membranes of rat testes. Indian Journal of Biochemistry & Biophysics. 1991 Apr; 28(2): 136-9en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/26495
dc.language.isoengen_US
dc.source.urihttps://https://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijbb/ijbb0.aspen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCa(2+) Mg(2+)-ATPase --metabolismen_US
dc.subject.meshCalcium-Transporting ATPases --metabolismen_US
dc.subject.meshChlorpromazine --pharmacologyen_US
dc.subject.meshGossypol --pharmacologyen_US
dc.subject.meshIntracellular Membranes --enzymologyen_US
dc.subject.meshKineticsen_US
dc.subject.meshMaleen_US
dc.subject.meshMicrosomes --enzymologyen_US
dc.subject.meshRatsen_US
dc.subject.meshTestis --enzymologyen_US
dc.titleEffect of chlorpromazine and gossypol on Ca(2+)-ATPase activity in the microsomal membranes of rat testes.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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