Isoproterenol ameliorates workstress-induced rat skeletal muscle degeneration.

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dc.contributor.authorGarg, Ashaen_US
dc.contributor.authorSharma, Sushmaen_US
dc.date.accessioned2006-04-08en_US
dc.date.accessioned2009-05-27T09:54:52Z
dc.date.available2006-04-08en_US
dc.date.available2009-05-27T09:54:52Z
dc.date.issued2006-04-08en_US
dc.description.abstractBeta-Agonists though have been widely studied for their protein anabolic effects in skeletal muscles, but the lipid status under work stress and agonist treatment have not been understood well in the skeletal muscles and heart of rat. In the present study, adult male Wistar rats were subjected to work overload stress and beta agonist isoproterenol treatment (2 mg kg(-1) day(-1) intraperitoneally) to examine, whether it attenuates work stress-induced changes or not. Simultaneously, beta2 antagonist butoxamine (2 mg kg(-1) day(-1) intraperitoneally) was administered to another isoproterenol-treated group. Work stress led to myofibrillar degeneration as well as rapid utilization of lipid to meet increased energy demands and for muscle repair, which was reflected through histochemical localization of lipids and biochemical estimation of cholesterol and triglycerides. Significantly decreased cholesterol levels in skeletal muscles and heart muscles were noticed. As expected, isoproterenol reversed the conditions by raising cholesterol and triglyceride levels significantly in the skeletal muscles and also by ameliorating the degenerative changes in muscle fibres as induced by work overload. However, severe accumulation of lipids in heart infers towards deleterious effects of isoproterenol on heart and thus remains a limiting factor for its immediate clinical application. Further research is needed to separate desirable effects of beta agonists on skeletal muscles from any undesirable effects on the heart, so as to optimize their therapeutic potential.en_US
dc.description.affiliationDepartment of Biosciences, Himachal Pradesh University, Shimla 171 005, India.en_US
dc.identifier.citationGarg A, Sharma S. Isoproterenol ameliorates workstress-induced rat skeletal muscle degeneration. Indian Journal of Biochemistry & Biophysics. 2006 Apr; 43(2): 82-7en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/28935
dc.language.isoengen_US
dc.source.urihttps://https://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijbb/ijbb0.aspen_US
dc.subject.meshAdrenergic beta-Agonists --pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshHeart --drug effectsen_US
dc.subject.meshIsoproterenol --pharmacologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMotor Activity --physiologyen_US
dc.subject.meshMuscle, Skeletal --drug effectsen_US
dc.subject.meshMuscular Atrophy --drug therapyen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Wistaren_US
dc.subject.meshStress, Physiological --physiopathologyen_US
dc.titleIsoproterenol ameliorates workstress-induced rat skeletal muscle degeneration.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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