Antisense interleukin-5 reduces eosinophil infiltration and hyperrespon-siveness in an allergic asthma model.

dc.contributor.authorHuang, Feng-ying
dc.contributor.authorWang, Cai-chun
dc.contributor.authorZhou, Song-lin
dc.contributor.authorHuang, Yong-hao
dc.contributor.authorWang, Hua
dc.contributor.authorChen, Fan
dc.contributor.authorLin, Ying-ying
dc.contributor.authorTan, Guang-hong
dc.contributor.authorLiu, Jun-bao
dc.date.accessioned2012-01-05T08:31:01Z
dc.date.available2012-01-05T08:31:01Z
dc.date.issued2009-03
dc.description.abstractInterleukin-5 (IL-5) involves in the development of airway inflammation and hyperresponsiveness through activation of eosinophils. Thus, inhibition of IL-5 expression seems to be an attractive approach for asthma therapy. In this study, an antisense IL-5 gene transferred by recombinant adeno-associated virus (asIL-5) was constructed to transfect murine allergic asthma model. Our results showed that asIL-5 efficiently inhibited the IL-5 mRNA expression and significantly attenuated the inflammation in lung tissues. Significant decreasing of eosino-phils and inflammatory cells were found in peripheral blood and bronchoalveolar lavage fluid (BALF). In addition, significant inhibition of airway hyperresponsiveness (AHR) was also found in the mice treated with asIL-5. These observations demonstrate that antisense oligonucleotid against IL-5 delivered by adeno-associated virus system is possibly an efficacious therapeutic strategy for allergic asthma and other eosinophil-related disorders.en_US
dc.identifier.citationHuang Feng-ying, Wang Cai-chun, Zhou Song-lin, Huang Yong-hao, Wang Hua, Chen Fan, Lin Ying-ying, Tan Guang-hong, Liu Jun-bao. Antisense interleukin-5 reduces eosinophil infiltration and hyperrespon-siveness in an allergic asthma model. Asian Pacific Journal of Allergy and Immunology, 2009 Mar; 27(1): 35-41.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/136273
dc.language.isoenen_US
dc.source.urihttps://apjai.digitaljournals.org/index.php/apjai/article/viewFile/36/48en_US
dc.titleAntisense interleukin-5 reduces eosinophil infiltration and hyperrespon-siveness in an allergic asthma model.en_US
dc.typeArticleen_US
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