Wound healing potential of flowers extracts of Woodfordia fruticosa Kurz.

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dc.contributor.authorVerma, Neeraj
dc.contributor.authorAmresh, G
dc.contributor.authorSahu, P K
dc.contributor.authorMishra, Neelam
dc.contributor.authorRao, Ch V
dc.contributor.authorSingh, Anil Pratap
dc.date.accessioned2013-10-03T10:38:43Z
dc.date.available2013-10-03T10:38:43Z
dc.date.issued2013-08
dc.description.abstractWound healing or repair is the body’s natural process of regenerating dermal and epidermal tissue. Woodfordia fruticosa Kurz (Family: Lythraceae) is used traditionally in wound healing by the tribals of Chhattisgarh district. However, there is a paucity of scientific data in support. In this study, we evaluated antimicrobial activity of petroleum ether, chloroform, ethanolic and aqueous extracts against a diverse range of gram +ve and gram -ve bacteria along with pathogenic fungi. The wound healing activity of ethanolic extract was also evaluated at dose levels of 250 and 500 mg/kg body wt in rats by excision, incision and dead space wound healing models along with histopathology of wound area of skin. The ethanolic extract showed potent wound healing activity, as evident from the increase in the wound contraction and breaking strength in dose-dependent manner. Treatment with ethanolic extract (250 and 500 mg/kg body wt) showed significant dose-dependently decrease in epithelization period and scar area. Hydroxyproline, hexuronic acid and hexosamine contents, the important constituents of extracellular matrix of healing were also correlated with the observed healing pattern. During early wound healing phase, pro-inflammatory cytokines TNF-α, IL-6 and anti-inflammatory cytokine IL-10 levels were found to be upregulated by the ethanolic extract treatment. The ethanolic extract exhibited a strong and broad spectrum antimicrobial activity, as compared to other extracts. It showed very low Minimum inhibitory concentration (MIC) values and inhibited the growth of E. coli, Staphylococcus aureus and Candida albicans in concentration of 2.5 µg/disc. Thus, the results of the present study demonstrated the strong wound healing potential and antimicrobial activities of W. fruticosa, flowers, supporting the folklore use of the plant by the tribal people of Chhattisgarh district.en_US
dc.identifier.citationVerma Neeraj, Amresh G, Sahu P K, Mishra Neelam, Rao Ch V, Singh Anil Pratap. Wound healing potential of flowers extracts of Woodfordia fruticosa Kurz. Indian Journal of Biochemistry & Biophysics. 2013 Aug; 50(4): 296-304.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/148611
dc.language.isoenen_US
dc.source.urihttps://nopr.niscair.res.in/handle/123456789/20878en_US
dc.subjectAnti-inflammatory cytokinesen_US
dc.subjectAntimicrobialen_US
dc.subjectDead spaceen_US
dc.subjectExcisionen_US
dc.subjectIncisionen_US
dc.subjectPro-inflammatory cytokinesen_US
dc.subjectWoodfordia fruticosaen_US
dc.subjectWound healingen_US
dc.subject.meshAnimals
dc.subject.meshAnti-Infective Agents --pharmacology
dc.subject.meshEthanol --chemistry
dc.subject.meshFlowers --chemistry
dc.subject.meshInterleukin-10 --biosynthesis
dc.subject.meshInterleukin-6 --biosynthesis
dc.subject.meshMale
dc.subject.meshPlant Extracts --pharmacology
dc.subject.meshRats
dc.subject.meshRats, Wistar
dc.subject.meshTumor Necrosis Factor-alpha --biosynthesis
dc.subject.meshWoodfordia --chemistry
dc.subject.meshWound Healing --drug effects
dc.titleWound healing potential of flowers extracts of Woodfordia fruticosa Kurz.en_US
dc.typeArticleen_US
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