Effect of enterotoxin on glutathione status in the intestinal mucosa.

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dc.contributor.authorBenard, Oen_US
dc.contributor.authorBalasubramanian, K Aen_US
dc.date.accessioned1996-10-01en_US
dc.date.accessioned2009-05-27T09:13:34Z
dc.date.available1996-10-01en_US
dc.date.available2009-05-27T09:13:34Z
dc.date.issued1996-10-01en_US
dc.description.abstractThe effect of luminal exposure of enterotoxins on the intestinal mucosal glutathione (GSH) was studied in rat. Cholera toxin induced fluid secretion and decreased mucosal GSH by 35% without altering oxidized glutathione (GSSG) level. Toxin induced fluid secretion was tested after mucosal GSH depletion by compounds such as diethyl maleate (DEM) and buthionine sulfoximine (BSO) and thiol supplementation with N-Acetyl cysteine (NAC). Fluid secretion was not altered by prior thiol depletion or supplementation. Exposure of intestinal lumen to bacterial endotoxin resulted in 25% decrease in mucosal GSH with two fold increase in GSSG. Luminal exposure of Shiga toxin did not alter the mucosal thiol. The level of other low molecular weight thiols, cysteine and cystine was not altered by luminal exposure of any of these toxins. These results show that although cholera toxin decreased the mucosal GSH level, prior modulation of thiol status of the mucosa may not have any effect on toxin-induced fluid secretion.en_US
dc.description.affiliationWellcome Research Laboratory, Department of Gastrointestinal Sciences, Christian Medical College Hospital, Vellore, India.en_US
dc.identifier.citationBenard O, Balasubramanian KA. Effect of enterotoxin on glutathione status in the intestinal mucosa. Indian Journal of Biochemistry & Biophysics. 1996 Oct; 33(5): 409-13en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/26853
dc.language.isoengen_US
dc.source.urihttps://https://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijbb/ijbb0.aspen_US
dc.subject.meshAnimalsen_US
dc.subject.meshButhionine Sulfoximine --pharmacologyen_US
dc.subject.meshCholera Toxin --toxicityen_US
dc.subject.meshCysteine --metabolismen_US
dc.subject.meshEndotoxins --toxicityen_US
dc.subject.meshGlutathione --analogs & derivativesen_US
dc.subject.meshGlutathione Disulfideen_US
dc.subject.meshIntestinal Mucosa --drug effectsen_US
dc.subject.meshMaleates --pharmacologyen_US
dc.subject.meshRatsen_US
dc.subject.meshSulfhydryl Compounds --metabolismen_US
dc.titleEffect of enterotoxin on glutathione status in the intestinal mucosa.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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