Respiratory mechanics of infants with bronchopulmonary dysplasia who required long term oxygen therapy
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Date
2010-04-09
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Thai Journal of Tuberculosis Chest Diseases and Critical Care
Abstract
Respiratory mechanics (RM) were prospectively and longitudinally studied in a cohort of 23 infants with bronchopulmonary dysplasia (BPD).\ The aim of this study was to compare pulmonary function in BPD infants who required supplemental oxygen for more than 2 months (the study group, n=15) and in age-matched BPD infants who required supplemental oxygen at 2 months or less (the control group, n=8). Serial pulmonary functions were measured, using a computerized infant pulmonary function device (model 2600; SensorMedics; Yorba Linda, CA, USA), at 6, 12, 18, and 24 months of corrected age. Both groups did not differ for sex, birth weight, gestational age, duration of mechanical ventilation, history of patent ductus arteriosus or respiratory distress syndrome. At 6 months of age, compliance of the respiratory system (Crs) in the study group was significantly lower than the control group (6.8\±2.9 vs. 11.7\±3.6 ml/cm H₂O, p \< 0.05) and at 6, 12, and 18 months of age. Tidal volume in the study group was significantly lower than the control group (43.8\±11.9 vs. 62.4\±14.9 ml; 62.1\±11.8 vs. 79.7\±15.9 ml; 79.9\±14.2 vs. 96.5\±19.1 ml; p \< 0.05).\ Other pulmonary function including functional residual capacity and total respiratory system resistance (Rrs) did not differ between the two groups. We conclude that the pulmonary function status of BPD infants who required supplemental oxygen for more than 2 months need longer time period for recovering from lung injury than the control group.
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Thai Journal of Tuberculosis Chest Diseases and Critical Care; Vol.29 No.4 October-December 2008; 309-317