An Optimization Of Sterically Stabilized Liposome Using Design Of Experiment Approach
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Date
2020-07
Journal Title
Journal ISSN
Volume Title
Publisher
MRI Publication Pvt. Ltd.
Abstract
Purpose: Recently, drug delivery system with controlled and targeted drug release at the tumor sites emerged as an attractive option for improving anticancer therapeutics. Advanced Nano therapeutics must not be limited to nano scale but should find their way to target the solid tumor via direct or indirect way. Pegylation on the surface of liposome helps to become liposome as long circulating and indirect or passive targeting to tumor. Purpose of this study is to develop and optimize the critical process parameters which plays important role in the quality pegylated liposome. Design of experiment (DOE) was used to study the impact of critical process variables like hydration temperature, extrusion process temperature, ethanol concentration, drug loading temperature and drug loading time.
Description
Keywords
Vincristine, Sterically stabilized liposome, Pegylated liposome, design of experiment, remote loading
Citation
Patel N., Patel D.. An Optimization Of Sterically Stabilized Liposome Using Design Of Experiment Approach. International Journal of Pharmaceutical Sciences and Drug Research. 2020 Jul; 12(4): 331-343